A novel optical imaging probe system for assessing wound healing and infection

一种用于评估伤口愈合和感染的新型光学成像探针系统

基本信息

批准号：
8591219
负责人：
Wenjing Hu
金额：
$ 19.99万
依托单位：
PROGENITEC, INC.
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-01 至 2015-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8591219
关键词：
Acute Affect American Area Arthritis Bacteria Beds Binding Carbohydrates Caring Cells Chronic Clinical Complex Decubitus ulcer Detection Development Diabetic ulcer Diagnosis Diagnostic Diagnostic Procedure Disease Dyes Early Diagnosis Elements Environment Equipment Evaluation Fibroblasts Fluorescence Fluorescent Dyes Functional Imaging Goals Healed Human Image Imaging Techniques Imaging technology Impaired wound healing In Vitro Infection Infectious Skin Diseases Inflammation Knowledge Lead Lectin Ligand Binding Malignant Neoplasms Measures Medical Methods Modeling Monitor Mus Optics Oxygen Pathogenesis Patient Care Patients Peptide Hydrolases Physiological Polyethylene Glycols Process Saline Sambucus nigra Series Skin Specificity Staging Sterility System Technology Testing Time Tissues Toxic effect Ulcer Varicose Ulcer Work Wound Healing Wound Infection angiogenesis base biomaterial compatibility cardiovascular infection cost effective therapy fluorophore healing imaging probe in vivo migration new technology novel optical imaging particle pathogenic bacteria phase 1 study phase 2 study public health relevance ratiometric tool wound

项目摘要

DESCRIPTION (provided by applicant): Chronic non-healing wounds continue to pose great challenges to clinicians. It is estimated that there are 1.1-1.8 million new chronic wound patients each year and approximately 8 million Americans suffering from chronic wounds. To make the situation worse, chronic wounds often predispose the patients to infection. The problem is compounded by the lack of effective methods to monitor the wound healing status and for the early diagnosis of wound infection. Taking advantage of the recent developments in optical imaging technology, the overall goal of this project is to develop a multifunctional imaging probe for assessing wound healing and infection in humans. Specifically, many recent studies have shown that an alkaline (pH > 7.4) wound environment is an indicator of a chronic wound. It has also been shown that bacterial colonization is preferable in a chronic wound and alkaline environment. In addition, infection may delay wound healing and lead to an inability to heal. Hence, we believe that the development of imaging probes to detect the wound pH changes and bacterial colonization, would serve as powerful tools for early detection of non-healing wounds and wound infection. To achieve the goal, this proposed work is aimed at creating a series of near infrared bacteria/pH multifunctional probes which can measure pH changes and bacteria presence in the wound. The successful completion of this proposed work will aid in the development of a new platform of wound care technology. This technology can be easily implemented for monitoring the extent of wound healing and the potential for infection in chronic wound patients.

描述（由申请人提供）：慢性不愈合伤口继续给临床医生带来巨大挑战。预计新增慢性伤口患者1.1-180万每年约有 800 万美国人患有慢性伤口。更糟糕的是，慢性伤口常常使患者容易感染。由于缺乏有效的方法来监测伤口愈合状态和早期诊断伤口感染，问题变得更加复杂。利用光学成像技术的最新发展，该项目的总体目标是开发一种用于评估人类伤口愈合和感染的多功能成像探头。具体来说，最近的许多研究表明，碱性（pH > 7.4）伤口环境是慢性伤口的指标。还表明，在慢性伤口和碱性环境中，细菌定植是优选的。此外，感染可能会延迟伤口愈合并导致无法愈合。因此，我们相信，开发成像探针来检测伤口pH值变化和细菌定植，将成为早期检测不愈合伤口和伤口感染的有力工具。为了实现这一目标，这项工作旨在创建一系列近红外细菌/pH多功能探针，可以测量伤口中的pH变化和细菌存在。这项拟议工作的成功完成将有助于开发伤口护理技术的新平台。该技术可以轻松实施，用于监测慢性伤口患者的伤口愈合程度和感染的可能性。