Effects of Biofilm Activities and Dental Resin Composite Compositions on the Deve

生物膜活性和牙科树脂复合组合物对开发的影响

• 批准号: 8420748
• 负责人: Clifton M Carey
• 金额: $ 34.49万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-10 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8420748
• 关键词: Effects; Biofilm; Activities; Dental; Resin

DESCRIPTION (provided by applicant): The primary objectives of this project are to better understand the factors that lead to the development of secondary caries and to identify strategies to increase the service life of resin composite restorations. Restoration replacements due to secondary caries occupies a large portion of the dentist's practices. In 1999, 86 million composites were placed by dentists in this country and 122.7 million in 2006. The average replacement time is now only 5.7 years. Significant improvements in the long-term integrity of so many restorations could save the American people (by reducing costs of replacing restorations) many times the amount of money required to support this work. There is tremendous significance in the successful pursuit of this endeavor to benefit so many millions of people. We propose to study the effects of biofilm activity and dental resin composite compositions on the development of secondary caries. We will use a bioreactor model that utilizes conditions found in the oral environment to understand the role of microbial biofilms, salivary pellicles, and cyclic loading in the processes of secondary caries formation. While the bioreactor model establishes the conditions for the cyclic remineralization/demineralization attacks, we will use a variety of oral-simulating challenges and analytical methods to assess their effects on composite-restored teeth. We hypothesize that major contributors to defects at restoration margins include: interfacial stresses from contractions induced by polymerization shrinkage of resins, salivary esterases, acidogenic microbe-generated biofilms, and deformations from cyclic loading and oral thermal fluctuations. These can lead to subsequent staining, secondary caries, fractures, or other problems. The long-term goals of this project are to identify and prepare an optimally cross-linking composite composition resin that can restore defective teeth and defy environmental degradation (Aim 1); determine the effects of polymerization shrinkage on the development of degradation at the tooth-composite interface (Aim 2); understand the roles of salivary pellicles and microbial biofilms in the etiology of secondary caries' association with composite restorations (Aim 3); and develop beneficial biofilms in synergy with fluoride therapies that have the potential of retarding the onset of secondary caries (Aim 4). Our goal is to understand the physical, chemical and biological factors that determine the length of time a restoration lasts. With this understanding, we will develop more stable resin-based composites and methods to prevent the decay that limits the success of composite restorations. PUBLIC HEALTH RELEVANCE: This project is focused on developing strategies to increase the service life of resin composite restorations. Our goal is to understand the physical, chemical and biological factors that determine the length of time a restoration lasts. With this understanding, we will develop more stable resin-based composites and methods to prevent the decay that limits the success of composite restorations.

描述（由申请人提供）：该项目的主要目标是更好地了解导致继发龋的因素，并确定延长树脂复合材料修复体使用寿命的策略。由于继发性龋齿而进行的修复替换占据了牙医实践的很大一部分。 1999年，该国牙医放置了8600万颗复合材料，2006年为1.227亿颗。现在平均更换时间仅为5.7年。如此多的修复体的长期完整性的显着改善可以为美国人民节省（通过降低更换修复体的成本）许多倍于支持这项工作所需的资金。成功实现这一目标，造福千百万人民，具有重大意义。我们建议研究生物膜活性和牙科树脂复合组合物对继发龋发展的影响。我们将使用生物反应器模型，利用口腔环境中的条件来了解微生物生物膜、唾液膜和循环负荷在继发龋齿形成过程中的作用。虽然生物反应器模型建立了循环再矿化/脱矿化攻击的条件，但我们将使用各种口腔模拟挑战和分析方法来评估它们对复合材料修复牙齿的影响。我们假设修复体边缘缺陷的主要贡献者包括：树脂聚合收缩引起的界面应力、唾液酯酶、产酸微生物产生的生物膜以及循环负载和口腔热波动引起的变形。这些可能会导致随后的染色、继发龋齿、骨折或其他问题。该项目的长期目标是确定和制备一种最佳交联复合组合物树脂，可以修复有缺陷的牙齿并抵抗环境退化（目标1）；确定聚合收缩对牙齿-复合材料界面降解发展的影响（目标 2）；了解唾液膜和微生物生物膜在复合修复体继发龋病病因学中的作用（目标 3）；并与氟化物疗法协同形成有益的生物膜，有可能延缓继发龋的发生（目标 4）。我们的目标是了解决定修复持续时间长度的物理、化学和生物因素。有了这种认识，我们将开发更稳定的树脂基复合材料和方法，以防止限制复合材料修复成功的腐烂。 公共健康相关性：该项目的重点是制定提高树脂复合材料修复体使用寿命的策略。我们的目标是了解决定修复持续时间长度的物理、化学和生物因素。有了这种认识，我们将开发更稳定的树脂基复合材料和方法，以防止限制复合材料修复成功的腐烂。