Using MaqFACS to measure facial movement deficits in monkeys

使用 MaqFACS 测量猴子的面部运动缺陷

基本信息

批准号：
8317537
负责人：
LISA A. PARR
金额：
$ 22万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-15 至 2015-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8317537
关键词：
Adult Affect Animal Model Antiparkinson Agents Award Behavior Behavioral Belief Bradykinesia Certification Chronic Clinical Code Corpus striatum structure Data Development Disease Dopamine Agonists Dose Effectiveness Emotional Ensure Exposure to Face Facial Expression Facial Muscles Functional disorder Funding Goals Gold Human Hypokinesia Impairment Individual Laboratories Macaca mulatta Manuals Masks Measurement Measures Mental disorders Methods Modeling Monitor Monkeys Motor Movement Movement Disorders Neurodegenerative Disorders Parkinson Disease Parkinsonian Disorders Posture Primates Procedures Publishing Recovery of Function Research Research Personnel Services Severities Study models Symptoms System Testing Training Tremor United States National Institutes of Health Video Recording base behavior rating scale cost dopaminergic neuron early onset effective therapy interdisciplinary collaboration interest movie pramipexol response social standard measure tool

项目摘要

DESCRIPTION (provided by applicant): Parkinson's Disease (PD) is a progressive neurodegenerative disorder caused by a depletion of dopamine (DA) neurons in the striatum. Its major symptoms are movement- related, including tremors, bradykinesis, stooped posture, and masked facial affect. There are several monkey models for studying the pathophysiology of PD. The most widely used involves a MPTP, a substance that is toxic to dopaminergic neurons and very accurately mirrors the underlying cause, symptoms and progression of PD in humans. To assess the motor-related impairments in MPTP monkeys, researchers have adapted traditional clinical rating systems, but until recently, no standardized measurement system has been available to assess deficits in facial expressivity, despite this being a debilitating symptom of PD in humans. The FACS (Facial Action Coding System) is the gold standard for measuring facial movement in humans. FACS is anatomically-based as it identifies facial movement according to the underlying action of facial muscles. Researchers have used FACS to reveal deficits in both the type and intensity of facial expressions made by people with PD. Investigators have recently developed a monkey FACS (MaqFACS) and pilot data in MPTP monkeys suggest that this system may be a more sensitive measure of early onset PD than traditional rating systems. This project will directly assess the effectiveness of MaqFACS, compared to other rating systems (activity monitoring and a behavioral rating scale), in characterizing the progression of PD symptoms in MPTP-treated monkeys. Facial movement will be video recorded and then coded using MaqFACS during baseline sessions as well as two emotional provocations (exposure to a mirror and response to movies of other monkeys) to evoke facial expressivity. Inter-individual variability in facial movement will be quantified and changes in the type and amount of facial movement will be compared across the MPTP-treatment progression. The PD monkeys will then be given a DA agonist to reverse their symptoms and recovery of function will be assessed using the same testing and measurement procedures. These data will validate the effectiveness of MaqFACS in identifying the early onset of PD symptoms in the most common monkey model of PD and aid in the development of effective treatments.

描述（由申请人提供）：帕金森病（PD）是一种由纹状体中多巴胺（DA）神经元耗竭引起的进行性神经退行性疾病。其主要症状与运动有关，包括震颤、运动迟缓、弯腰姿势和掩盖面部表情。有几种猴子模型可用于研究 PD 的病理生理学。最广泛使用的是 MPTP，这是一种对多巴胺能神经元有毒的物质，并且非常准确地反映了人类 PD 的根本原因、症状和进展。为了评估 MPTP 猴子的运动相关障碍，研究人员采用了传统的临床评级系统，但直到最近，还没有标准化的测量系统可以评估面部表情缺陷，尽管这是人类 PD 的一种令人衰弱的症状。 FACS（面部动作编码系统）是测量人类面部运动的黄金标准。 FACS 是基于解剖学的，因为它根据面部肌肉的基本动作来识别面部运动。研究人员使用 FACS 揭示了帕金森病患者面部表情类型和强度的缺陷。研究人员最近开发了一种猴子 FACS (MaqFACS)，MPTP 猴子的试验数据表明，该系统可能是比传统评级系统更敏感的早发 PD 测量方法。该项目将直接评估 MaqFACS 与其他评级系统（活动监测和行为评级量表）相比在描述 MPTP 治疗猴子 PD 症状进展方面的有效性。面部运动将被视频记录，然后在基线会话期间以及两次情绪刺激（暴露在镜子前和对其他猴子的电影做出反应）期间使用 MaqFACS 进行编码，以唤起面部表情。将量化面部运动的个体间差异，并在 MPTP 治疗过程中比较面部运动类型和数量的变化。然后，PD 猴子将被给予 DA 激动剂来逆转它们的症状，并使用相同的测试和测量程序来评估功能的恢复。这些数据将验证 MaqFACS 在识别最常见的 PD 猴子模型中早期出现的 PD 症状方面的有效性，并有助于开发有效的治疗方法。