Functional Brain Networks: A Novel Approach to Address Clinical Challenges in PD
功能性大脑网络:解决帕金森病临床挑战的新方法
基本信息
- 批准号:8599017
- 负责人:
- 金额:$ 0.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-30 至 2015-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdverse effectsAffectAlgorithmsAnimal ModelAnimalsAreaArtsAuthorshipAutopsyBackBasal GangliaBasic ScienceBehavior assessmentBehavioralBioinformaticsBiological MarkersBiological ProcessBiomedical ResearchBiometryBlood - brain barrier anatomyBlood flowBrainBrain imagingBrain regionCaringCellsCerebrovascular CirculationCerebrumClinicClinicalClinical ResearchCognitionCognitiveCollaborationsComorbidityComplexComplicationCorpus striatum structureDataDevelopmentDiagnosticDifferential DiagnosisDisadvantagedDiseaseDissociationDoctor of PhilosophyDopamineDopamine AgonistsDyskinetic syndromeEarly DiagnosisEndotheliumEventExperimental Animal ModelFunctional ImagingFunctional disorderFundingFutureGenesGoalsGrowthHealth BenefitHumanImageImage AnalysisImaging DeviceImaging TechniquesImpaired cognitionIndividualIndividual DifferencesInformaticsInstitutesInvestigationKnowledgeLeadLeadershipLearningLevodopaMagnetic Resonance ImagingMapsMeasurementMeasuresMediatingMedical ResearchMedicineMemoryMetabolismMethodsMissionModelingMolecularMolecular MedicineMood DisordersMotorMovement DisordersNafionNerve DegenerationNetwork-basedNeurodegenerative DisordersNeurologyNeurosciencesNoiseOutcomeParkinson DiseaseParkinsonian DisordersPathogenesisPathway AnalysisPathway interactionsPatientsPatternPeripheralPermeabilityPharmaceutical PreparationsPhysiciansPopulationPrincipal InvestigatorProcessPropertyPsychometricsPsychophysicsPublicationsRadiochemistryRattusRecruitment ActivityResearchResearch InfrastructureResearch PersonnelResidenciesRestRewardsRodent ModelRoleRubidiumScientistSignal TransductionSorting - Cell MovementStagingSwedenSymptomsSystemSystems BiologyTestingTimeTracerTrainingTraining SupportTraining and EducationTranslatingTranslational ResearchTranslationsTwin Multiple BirthUnited States National Institutes of HealthUniversitiesValidationVasomotorWorkangiogenesisauthoritybasebench to bedsidecareerclinical practiceclinically relevantcognitive changecognitive neurosciencecomputer sciencedata sharingeffective therapyexperiencefollower of religion Jewishgraduate studenthemodynamicshigh riskhuman diseaseimprovedindexinginnovationinsightinstrumentinterdisciplinary collaborationmedical schoolsmedical specialtiesmemberneuroimagingnew therapeutic targetnorth shore long islandnovelnovel strategiespatient orientedpatient oriented researchpatient populationprogramspublic health relevancerelating to nervous systemresearch studyresponsesuccesstooltranslational approachtreatment responsevasculogenesis
项目摘要
DESCRIPTION (provided by applicant): Parkinson's disease (PD) is characterized by both motor and non-motor symptoms (cognitive impairment, affective disorder, and other clinical features). Data from experimental animal models and patients with PD indicate that the manifestations of this disease cannot be attributed to isolated dysfunction of the basal ganglia. Rather, the highly localized loss of nigral dopamine cells is associated with a broad, spatially distributed set of functional abnormalities involving cortico-striato-pallido-thalamocortical (CSPTC) loops and related pathways. By quantifying the activity of spatially distributed (large-scale) functional brain networks, comprising multiple interconnected brain regions, modern techniques of image-based analysis can provide valuable information concerning the widespread circuit abnormalities that underlie neurodegenerative disorders such as PD. The investigators at the Center for Neurosciences at The Feinstein Institute, led by Dr. Eidelberg, have pioneered the use of functional brain imaging and network analysis for the study of PD and related neurodegenerative diseases. Because of the noise inherent in "small signals" analyses of this sort, we have emphasized rigorous validation of the disease-related functional patterns from both statistical and empiric standpoints. Indeed, high levels of measurement precision are needed before quantitative network measures can be considered as potential biomarkers of the disease process and its response to treatment.
In this proposal, we seek to take this approach to a new level by employing rigorously validated PD-related networks to address a number of vital issues that impact heavily on the care of today's PD patients. Project 1 addresses the serious clinical problem of levodopa-induced dyskinesias, which ultimately affect nearly all PD patients. Project 2 examines the network basis for individual differences in the cognitive response to dopaminergic treatment with a view to predicting which patients will develop untoward cognitive side effects under different treatment conditions. Project 3 aims to establish the feasibility of a new network-based algorithm for providing earlier and more accurate differential diagnosis than is currently possible.
描述(由申请人提供):帕金森病(PD)的特征是运动和非运动症状(认知障碍、情感障碍和其他临床特征)。来自实验动物模型和 PD 患者的数据表明,这种疾病的表现不能归因于基底神经节的孤立功能障碍。相反,黑质多巴胺细胞的高度局部丧失与一系列广泛的、空间分布的功能异常有关,涉及皮质-纹状体-苍白球-丘脑皮质(CSPTC)环路和相关通路。通过量化由多个相互连接的大脑区域组成的空间分布(大规模)功能性大脑网络的活动,基于图像的现代分析技术可以提供有关帕金森等神经退行性疾病背后的广泛回路异常的有价值的信息。由 Eidelberg 博士领导的范斯坦研究所神经科学中心的研究人员率先使用功能性脑成像和网络分析来研究帕金森病和相关的神经退行性疾病。由于此类“小信号”分析中固有的噪声,我们强调从统计和经验的角度严格验证与疾病相关的功能模式。事实上,在定量网络测量被视为疾病过程及其对治疗反应的潜在生物标志物之前,需要高水平的测量精度。
在本提案中,我们寻求通过采用经过严格验证的 PD 相关网络来解决对当今 PD 患者护理产生重大影响的许多重要问题,从而将这种方法提升到一个新的水平。项目 1 解决左旋多巴引起的运动障碍的严重临床问题,该问题最终影响几乎所有 PD 患者。项目 2 检查多巴胺能治疗认知反应个体差异的网络基础,以预测哪些患者在不同治疗条件下会出现不良认知副作用。项目 3 旨在建立一种新的基于网络的算法的可行性,以提供比目前更早、更准确的鉴别诊断。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
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DAVID EIDELBERG其他文献
DAVID EIDELBERG的其他文献
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{{ truncateString('DAVID EIDELBERG', 18)}}的其他基金
Neurovascular Effects of Dopamine Replacement Therapy in Parkinson's Disease
多巴胺替代疗法对帕金森病的神经血管作用
- 批准号:
10421077 - 财政年份:2019
- 资助金额:
$ 0.5万 - 项目类别:
Neurovascular Effects of Dopamine Replacement Therapy in Parkinson's Disease
多巴胺替代疗法对帕金森病的神经血管作用
- 批准号:
10200914 - 财政年份:2019
- 资助金额:
$ 0.5万 - 项目类别:
Neurovascular Effects of Dopamine Replacement Therapy in Parkinson's Disease
多巴胺替代疗法对帕金森病的神经血管作用
- 批准号:
10631133 - 财政年份:2019
- 资助金额:
$ 0.5万 - 项目类别:
Neurovascular Effects of Dopamine Replacement Therapy in Parkinson's Disease
多巴胺替代疗法对帕金森病的神经血管作用
- 批准号:
10019416 - 财政年份:2019
- 资助金额:
$ 0.5万 - 项目类别:
Structure-Function Relationships in Dystonia: A Network Approach
肌张力障碍的结构-功能关系:网络方法
- 批准号:
8241911 - 财政年份:2011
- 资助金额:
$ 0.5万 - 项目类别:
Structure-Function Relationships in Dystonia: A Network Approach
肌张力障碍的结构-功能关系:网络方法
- 批准号:
8448201 - 财政年份:2011
- 资助金额:
$ 0.5万 - 项目类别:
Structure-Function Relationships in Dystonia: A Network Approach
肌张力障碍的结构-功能关系:网络方法
- 批准号:
8699851 - 财政年份:2011
- 资助金额:
$ 0.5万 - 项目类别:
Structure-Function Relationships in Dystonia: A Network Approach
肌张力障碍的结构-功能关系:网络方法
- 批准号:
8026548 - 财政年份:2011
- 资助金额:
$ 0.5万 - 项目类别:
Functional Brain Networks: A Novel Approach to Address Clinical Challenges in PD
功能性大脑网络:解决帕金森病临床挑战的新方法
- 批准号:
8549321 - 财政年份:2010
- 资助金额:
$ 0.5万 - 项目类别:
CORTICAL-SUBCORTICAL INTERACTION IN PARKINSON'S DISEASE AND NORMAL SPEECH
帕金森病和正常言语中的皮质-皮质下相互作用
- 批准号:
8167226 - 财政年份:2010
- 资助金额:
$ 0.5万 - 项目类别:
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