Sensorimotor Training to Affect Balance, Engagement and Learning in Children with

感觉运动训练可影响儿童的平衡、参与和学习

基本信息

批准号：
8526293
负责人：
TRACY L JIRIKOWIC
金额：
$ 19.24万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2014-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8526293
关键词：
Address Affect Aftercare Age Animal Model Area Attention Balance training Behavior Behavioral Biometry Cerebral Palsy Child Childhood Clinical Clinical assessments Collaborations Complex Computers Conflict (Psychology)Control Groups Controlled Environment Data Development Developmental Disabilities Diagnosis Dose Educational Intervention Effectiveness Effectiveness of Interventions Emerging Technologies Engineering Environment Equilibrium Evaluation Fetal Alcohol Spectrum Disorder Foundations Funding Goals Home environment Intervention Laboratories Learning Maintenance Matched Group Measures Motor Movement Musculoskeletal Equilibrium Nature Neurodevelopmental Disability Neurodevelopmental Disorder Neurodevelopmental Impairment Neuronal Plasticity Occupational Therapy Outcome Outcome Measure Performance Phase Physical therapy Pilot Projects Play Population Process Protocols documentation Rehabilitation therapy Relative (related person)Reporting Research Research Proposals Risk Safety Sample Size Sampling Secondary to Sensorimotor functions Sensory Shapes Simulate Sports System Technology Testing Time Training Weight abstracting alcohol exposure autism spectrum disorder balance testing base behavioral health computer science daily functioning developmental disease equilibration disorder falls functional outcomes high risk improved meetings motor learning neurobehavioral neuromuscular novel physical conditioning postnatal prenatal exposure remediation response sensory integration sensory system skills social somatosensory stem treatment effect trend virtual reality visual-vestibular

项目摘要

Project Summary / Abstract RFA-MH-09-161: Novel Interventions for Neurodevelopmental Disorders R21/R33 Prenatal exposure to alcohol can increase the risk for lifelong neurobehavioral problems, as well as developmental disabilities that fall under the umbrella term of fetal alcohol spectrum disorders (FASD). Poor sensorimotor function, specifically balance deficits, is one area of neurodevelopmental impairment described among children with FASD. Efficient balance and postural control are important foundations for engagement in higher level functional skills such as maintaining attention, navigating an environment, controlling complex movements, and participating in childhood activities that promote physical and behavioral health and development. Balance is a complex process involving the integration sensory information and the coordination of neuromuscular responses. Despite evidence that balance deficits are problematic among children with FASD and preliminary reports that poor sensorimotor integration is suspect, the nature of these balance and postural control deficits are not fully understood. Nor have interventions to improve daily function and behavior through the remediation of underlying sensorimotor deficits been considered and tested among this population, Yet, evidence from alcohol exposed animal models indicates the capacity for neural plasticity, motor learning, and improved motor performance following complex rehabilitative training. Therefore, the overarching goal of this combined R21/R33 proposal is to determine the preliminary effectiveness of a sensorimotor intervention to improve balance and related functional and behavioral outcomes among children with FASD. Our proposed intervention will employ the use of virtual reality computer technology to train the ability to weight and reweight sensory information during balance perturbations invoked by simulated conditions of sensory conflict. As a first step, this research (R21) proposes to more fully describe balance impairments and subsequent functional impact of sensorimotor problems in children with FASD. This will be done by comparing the performance of children with FASD ages 7.0-14.9 years to a matched group of children with typical development on a battery of clinical tests and a novel assessment system that specifically examines how visual, vestibular and somatosensory information is used during balance. This data will shape the development of our proposed sensorimotor intervention technology and preliminary intervention protocol, which will be tested with a small group of children with FASD to gauge initial feasibility and responsiveness. Data from the R21 will lay the groundwork for the next phase of research (R33) that aims to refine the sensorimotor training for balance intervention technology and establish and test the effectiveness of the intervention delivered via a short-term intensive laboratory protocol or a longer term home-based protocol. Collectively, these studies lay the essential groundwork for a larger multisite efficacy study to determine the effectiveness of the intervention with a larger sample of children with FASD and other groups of children with neurodevelopmental disabilities.

项目概要/摘要 RFA-MH-09-161：神经发育障碍的新型干预措施 R21/R33 产前接触酒精会增加终生神经行为问题的风险，以及属于胎儿酒精谱系障碍 (FASD) 范畴的发育障碍。贫穷的感觉运动功能，特别是平衡缺陷，是所描述的神经发育障碍的一个领域患有 FASD 的儿童中。有效的平衡和姿势控制是参与的重要基础更高水平的功能技能，例如保持注意力、驾驭环境、控制复杂的事物运动，以及参与促进身体和行为健康的童年活动发展。平衡是一个复杂的过程，涉及感觉信息的整合和协调的神经肌肉反应。尽管有证据表明患有平衡缺陷的儿童存在问题 FASD 和初步报告认为感觉运动整合不良是可疑的，这些平衡的本质和姿势控制缺陷尚不完全清楚。也没有改善日常功能和行为的干预措施通过在这一人群中考虑和测试潜在的感觉运动缺陷的修复，然而，来自暴露于酒精的动物模型的证据表明，神经可塑性、运动学习、并在复杂的康复训练后提高运动表现。因此，总体目标是该 R21/R33 联合提案旨在确定感觉运动干预的初步有效性改善 FASD 儿童的平衡以及相关的功能和行为结果。我们提出的干预将利用虚拟现实计算机技术来训练体重和重新体重的能力模拟感觉冲突条件引起的平衡扰动期间的感觉信息。作为第一个步骤，本研究（R21）建议更全面地描述平衡障碍和随后的功能障碍 FASD 儿童感觉运动问题的影响。这将通过比较性能来完成年龄为 7.0-14.9 岁的 FASD 儿童与具有典型电池发育的匹配儿童组临床测试和一个新颖的评估系统，专门检查视觉、前庭和平衡过程中使用体感信息。这些数据将影响我们提议的发展感觉运动干预技术和初步干预方案，将通过小规模测试一组患有 FASD 的儿童来评估最初的可行性和反应性。来自 R21 的数据将奠定下一阶段研究（R33）的基础，旨在完善平衡感觉运动训练干预技术，并通过短期的干预措施建立并测试其有效性强化实验室方案或长期家庭方案。总的来说，这些研究奠定了基础为更大规模的多中心功效研究奠定基础，以确定更大规模的干预措施的有效性患有 FASD 的儿童和其他患有神经发育障碍的儿童群体的样本。