Breast Cancer Research

乳腺癌研究

基本信息

批准号：
8376335
负责人：
LISA A CAREY
金额：
$ 18.69万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8376335
关键词：
Address African American Algorithms Animals Back Basic Research Breast Cancer Basic Science Bioinformatics Biological Biological Markers Biology Biopsy Breast Cancer Center Cancer Patient Clinic Clinical Clinical Investigator Clinical Research Clinical Trials Clinical Trials Design Collaborations Complex Core Facility Data Development Discipline Discrimination Drug Combinations Elderly Eligibility Determination Ensure Epidemiologic Studies Epidemiologist Epidemiology Epigenetic Process Extramural Activities Faculty Fostering Funding Funding Opportunities Future Genetic Genetically Engineered Mouse Genomics Goals Grant Group Meetings Heterogeneity Human Image Immune response Laboratories Laboratory Research Laboratory Scientists Lead Leadership Mammary Neoplasms Medical Medical Oncology Mentors Metastatic Neoplasm to the Central Nervous System Modeling Molecular Molecular Biology Molecular Profiling Monitor Mus Operative Surgical Procedures Outcome Participant Pathology Pharmacogenetics Phase Physician Executives Physicians Positioning Attribute Postdoctoral Fellow Protocols documentation Public Health Publishing Radiation Oncology Regimen Reporting Reproducibility Research Research Infrastructure Research Personnel Resource Allocation Risk Risk Factors Role Running Schools Science Scientist Soil Solutions Suggestion Testing Therapeutic Therapy Clinical Trials Time Tissues Translational Research Translations Validation Weight Woman Work anticancer research base career development clinical care clinical conference cost design drug development graduate student improved interdisciplinary approach malignant breast neoplasm medical schools meetings member mouse model multidisciplinary novel novel therapeutics oncology operation population based programs prospective symposium tool working group

项目摘要

Breast Cancer Research This program is focused upon making improvements in breast cancer patient regimens and outcomes, using an interdisciplinary approach. Our program hopes to achieve this goal by utilizing an improved understanding of the distinct biology of the intrinsic subtypes of breast cancer and breast cancer heterogeneity obtained through tissue-based studies, with additional biomarker discovery and validation, risk factor appraisal, and drug development, which lead to new therapeutic trials and population-based studies. Specifically, our strategic goals are: 1) basic and epidemiologic science discovery integrated with our existing understanding of the intrinsic breast cancer subtypes, 2) technological advances in imaging and therapy, 3) mouse models testing of promising therapeutic approaches in models representing the known biological subtypes, and 4) tissue-based discovery and clinical research algorithms for rational drug/combination studies with bidirectional strategies of containing embedded correlative/research biopsy studies. The Breast program is well suited to foster translation of basic science findings Into the clinic and back again because it is heavily integrated into a very active multidisciplinary clinical and clinical-translational operation, n addition, this program is seamlessly integrated with our mature breast cancer SPORE infrastructure that includes clinicians, epidemiologists, and laboratory scientists. Highlights of research by program investigators include development of genetically engineered mouse models representing many of tine intrinsic subtypes allowing subtype-specific therapeutic strategies to be tested in the mouse phase I unit (Perou, Sharpless), the development of anotechnology-based and other novel imaging that can be applied to both small animal and human breast cancers (Zhou, Pisano), and the design and execution of clinical trials using novel regimens and trial designs (Carey, Anders); the clinical focus remains on the manage of subtype-specific prospective clinical trials with targeted agents and embedded correlative analysis of molecular signatures and cross-trial validations. Substantial progress in understanding the risk factors and molecular biology of specific intrinsic subtypes has come from collaborations between faculty from the schools of Medicine, Public Health, and Genetics, including the first identification of the association of basal-like breast cancer with African-American women (Carey, Perou, MiDikan). The population-based Carolina Breast Cancer Study III is integral to this program and is examining subtype-specific risk factors and outcomes with a focus upon African-American women. Complementary studies are examining epigenetic and microenvironmental influences (Troester, Swift-Scanlan) that should address the "soil" contributions to these risks, and a new program in geriatric oncology is focusing upon molecular correlates of breast tumor and host response to therapy (Muss, Sharpless). The Program consists of 24 members from five different schools and clinicians from five different disciplines. In 2009, Breast Research Program members held 56 grants and $12.3M (total cost) in annual extramural funding, including 24 grants and $7.4M (total costs) from the NCI.

乳腺癌研究该计划的重点是使用跨学科方法改善乳腺癌患者方案和结果。我们的计划希望通过利用对通过基于组织的研究获得的乳腺癌内在亚型和乳腺癌异质性的独特生物学的了解来实现这一目标，并通过基于组织的研究获得了其他生物标志物发现和验证，危险因素评估和药物开发，这导致了新的治疗试验和基于人群的研究。具体而言，我们的战略目标是：1）基本和流行病学科学发现与我们现有的理解融为一体 2）成像和治疗方面的技术进步，3）代表已知生物亚型的模型中有希望的治疗方法的小鼠模型测试，以及4）基于组织的发现和基于组织的临床研究算法，用于含有含有型号的CoreLative Ibopsise/Research Insvient的临床药物/组合研究。该乳房程序非常适合将基础科学发现转化为诊所，然后再次返回，因为它已大量整合到非常活跃的多学科临床和临床翻译操作中，n补充，该计划与我们成熟的乳腺癌孢子基础设施无缝集成，其中包括临床医生，临床医生，流行病学科学家以及实验室科学家。计划研究者的研究亮点包括开发代表许多tine固有的亚型的基因工程鼠标模型，允许在鼠标I期单元（Perou，Sharpless）中测试亚型特异性治疗策略，可以使用基于厌食技术的小型动物和人类乳腺癌和人类乳腺癌（ZHHON）（ZHHON）（Sharpless）的开发，并将其应用于Anotechnology和其他新颖的成像（新颖的方案和试验设计（Carey，Anders）；临床重点保留在针对特定于靶向药物的特定于亚型前瞻性临床试验以及分子特征和跨审判验证的相关性分析上。在理解特定内在亚型的危险因素和分子生物学方面取得了重大进展，这来自医学，公共卫生和遗传学学院之间的合作，包括首先鉴定基底乳腺癌与非裔美国妇女（Carey，perou，perou，Midikan）。基于人群的卡罗来纳州乳腺癌研究III是该计划不可或缺的，正在研究亚型特异性危险因素和结果，重点是非裔美国妇女。互补研究正在研究应解决对这些风险的“土壤”贡献的表观遗传和微环境影响（TROESTER，SWIFT-SCANLAN），而老年肿瘤学的新计划则集中在乳腺肿瘤的分子相关性上，乳腺肿瘤的分子相关性和宿主对治疗的反应（MUSS，Sharpless）。该计划由来自五个不同学科的五个不同学校和临床医生的24名成员组成。 2009年，乳房研究计划成员持有56个赠款和1,230万美元（总费用）的年度资金，其中包括24个赠款和NCI的740万美元（总费用）。