Postdoctoral Research Training in Biotherapy of Cancer

癌症生物治疗博士后研究培训

• 批准号: 8337739
• 负责人: DAVID L BARTLETT
• 金额: $ 18.83万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8337739
• 关键词: Biological Response Modifier Therapy; Malignant Neoplasms; Research Training

DESCRIPTION (provided by applicant): This proposal is for the first renewal of a training program for surgical residents and surgical oncology fellows in translational research related to biologic therapies. The objective is to develop academic surgical oncologists using the following aims: (1) Recruit highly promising surgeons interested in surgical oncology, who are committed to a career in academic surgical oncology relevant to the biologic therapy of cancer, (2) Provide specific graduate course work to enhance their knowledge in molecular biology, immunology, biochemistry, cell biology, genetics, and clinical trials, as it relates to cancer and translationa research and (3) Provide an in-depth exposure to basic research skills by working with well-established mentors. We have a highly competitive group of surgical residents and surgical oncology fellows. Applicants include University of Pittsburgh surgical residents who are interested in surgical oncology, surgical oncology fellows from the University of Pittsburgh, and surgeons from other programs who are interested in biologic therapy research. Three surgeons will be supported by the program each year. They are provided a summary of the laboratories and encouraged to choose the lab that most interests them. Our group has a long standing interest and expertise in biologic therapies, and it is this strength that we propose to pass on to these trainees. Five defined research areas are offered: 1) Immunotherapy; 2) Cytokine Therapy; 3) Gene therapy; 4) Targeted Molecular Therapy; and 5) Genomics and Proteomics. Mentors are grouped within each field and a representative of each field is on the administrative committee. The training experience will consist of formal course work, seminars, journal clubs, and basic laboratory research. Basic laboratory research will form the bulk of the training experience. The trainees will all participate in graduate school courses on the principles and techniques of molecular biology, immunology, biochemistry, cell biology, genetics, and clinical trials, as well as courses on the responsible conduct of research each year. The trainees will enter a mentor's laboratory for two years, with an optional third year of training if approved by the Administrative Committee. The mentor evaluates the trainee every 6 months and communicates this evaluation to the Administrative Committee during the biannual Administrative Committee meeting. Following the Committee meeting, the trainee meets with the Program Director, at which time the trainee will be asked to evaluate his/her experience in the mentor's laboratory. A two-page written summary by each trainee evaluating their overall training experience is required at the conclusion of the research fellowship. While this program is relatively new, the feedback from the faculty and trainees has been excellent, and the academic productivity has been significant.

描述（由申请人提供）：该建议是针对与生物疗法有关的转化研究中的外科居民和外科肿瘤学研究员的培训计划的首次续签。 The objective is to develop academic surgical oncologists using the following aims: (1) Recruit highly promising surgeons interested in surgical oncology, who are committed to a career in academic surgical oncology relevant to the biologic therapy of cancer, (2) Provide specific graduate course work to enhance their knowledge in molecular biology, immunology, biochemistry, cell biology, genetics, and clinical trials, as it relates to cancer and Translationa Research和（3）通过与成熟的导师合作，为基础研究技能提供了深入的接触。我们有一群竞争激烈的外科手术居民和外科肿瘤学研究员。申请人包括匹兹堡大学的外科手术居民，他们对匹兹堡大学外科肿瘤学，外科肿瘤学研究员以及对生物治疗研究感兴趣的其他计划的外科医生感兴趣。每年该计划将为三名外科医生提供支持。他们提供了实验室的摘要，并鼓励他们选择最感兴趣的实验室。我们的小组在生物疗法方面具有长期的兴趣和专业知识，正是我们建议将这些学员传递给这些学员。提供了五个定义的研究领域：1）免疫疗法； 2）细胞因子疗法； 3）基因疗法； 4）靶向分子疗法； 5）基因组学和蛋白质组学。导师分组在每个领域，每个领域的代表都在行政委员会中。培训经验将包括正式的课程工作，研讨会，期刊俱乐部和基本实验室研究。基础实验室研究将构成大部分培训经验。学员将所有人都参加研究生院课程，讨论分子生物学，免疫学，生物化学，细胞生物学，遗传学和临床试验的原理和技术，以及每年负责任的研究课程。学员将进入导师的实验室两年，如果经行政委员会批准，则需要进行可选的第三年培训。导师每6个月评估学员，并在双年度行政委员会会议期间将此评估传达给行政委员会。委员会会议结束后，学员与计划主任会面，此时将要求学员评估他/她在导师实验室中的经验。在研究奖学金结束时，需要每个学员评估其整体培训经验的两页摘要。尽管该计划相对较新，但教职员工和学员的反馈非常出色，学术生产力也很重要。