Combined RCM and PSOCT for skin cancer imaging

结合 RCM 和 PSOCT 进行皮肤癌成像

基本信息

批准号：
8251261
负责人：
Mircea Mujat
金额：
$ 16.21万
依托单位：
PHYSICAL SCIENCES, INC
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8251261
关键词：
Algorithms Am 80 Basal cell carcinoma Benign Biological Biopsy Birefringence Cancer Patient Clinical Collaborations Confocal Microscopy Dermal Dermatologist Dermatology Dermis Dermoscopy Detection Devices Diagnosis Diagnostic Diagnostic Neoplasm Staging Emotional Engineering Epidermis Face Feedback Head Health Care Costs Healthcare Systems Human Image Imaging technology Invaded Investigation Lateral Lesion Malignant Neoplasms Marketing Measures Memorial Sloan-Kettering Cancer Center Methods Microscope Modality Mohs Surgery Morphology Nuclear Operative Surgical Procedures Optical Coherence Tomography Optics Papillary Pathologist Pathology Patients Performance Phase Pigments Pilot Projects Property Relative (related person)Reporting Research Resolution Screening procedure Sensitivity and Specificity Skin Skin Cancer Specificity Specimen Squamous cell carcinoma Staging Staining method Stains System Technology Testing Time Tissues Training Validation Visual base cancer diagnosis cancer imaging cancer site cost design experience imaging Segmentation improved in vivo instrument melanoma novel optical imaging phase 2 study physical science programs prototype skin lesion success treatment planning tv watching volunteer

Algorithms Am 80 Basal cell carcinoma Benign Biological Biopsy Birefringence Cancer Patient Clinical Collaborations Confocal Microscopy Dermal Dermatologist Dermatology Dermis Dermoscopy Detection Devices Diagnosis Diagnostic Diagnostic Neoplasm Staging Emotional Engineering Epidermis Face Feedback Head Health Care Costs Healthcare Systems Human Image Imaging technology Invaded Investigation Lateral Lesion Malignant Neoplasms Marketing Measures Memorial Sloan-Kettering Cancer Center Methods Microscope Modality Mohs Surgery Morphology Nuclear Operative Surgical Procedures Optical Coherence Tomography Optics Papillary Pathologist Pathology Patients Performance Phase Pigments Pilot Projects Property Relative (related person)Reporting Research Resolution Screening procedure Sensitivity and Specificity Skin Skin Cancer Specificity Specimen Squamous cell carcinoma Staging Staining method Stains System Technology Testing Time Tissues Training Validation Visual base cancer diagnosis cancer imaging cancer site cost design experience imaging Segmentation improved in vivo instrument melanoma novel optical imaging phase 2 study physical science programs prototype skin lesion success treatment planning tv watching volunteer

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项目摘要

DESCRIPTION (provided by applicant): Physical Sciences, Inc. (PSI), in collaboration with Memorial Sloan Kettering Cancer Center (MSKCC) and Lucid, Inc., proposes to investigate the use of combined reflectance confocal microscopy- polarization sensitive optical coherence tomography (RCM-PSOCT) for in vivo diagnosis of skin cancers. Both RCM and OCT are powerful technologies with proven success in human skin imaging. While RCM provides en face images with nuclear-level resolution in superficial skin, to depths of about 200 mm, OCT provides cross-sectional images with structural-level resolution in the deeper skin layers, to depths of at least 1 mm. Furthermore, PSOCT measures skin birefringence, and thus accurately differentiates between the dermal and epidermal skin layers. Therefore, the complementary capabilities of these two optical technologies may be exploited to offer a clinically comprehensive set of parameters for diagnostics which neither modality can provide by itself: presence and lateral spread of cancer, location of the dermo- epidermal junction and depth (stage) of invasion. Thus, this technology could help clinicians to provide more reliable diagnosis of suspicious skin lesions and significantly reduce the number of unnecessary biopsies. For a preliminary investigation of this powerful dual-mode imaging approach, a novel method for automated localization of the dermo-epidermal (DE) junction is proposed. In Phase I we propose to develop a benchtop instrument that will combine RCM and PSOCT within the same optical layout. Preliminary testing of this instrument will be performed on excised tissue specimens and on the normal skin of several volunteers. Based on Phase I conclusions, this instrument will be improved and a clinical prototype will be built and tested in a clinical setting on a larger number of normal and skin cancer patients during the Phase II study. PUBLIC HEALTH RELEVANCE: Reflectance confocal microscopy and optical coherence tomography are powerful optical imaging technologies for imaging biological tissue at the micron scale level. The combination of these technologies into an integrated microscope will enable noninvasive and real-time screening and diagnosis of skin cancers with high sensitivity and specificity, and thus could significantly reduce the number of unnecessary biopsies. Besides the elimination of emotional costs and patient discomfort, this technology may significantly reduce US healthcare costs by eliminating unnecessary biopsies.

描述（由申请人提供）：物理科学公司（PSI），与纪念斯隆·凯特林癌症中心（MSKCC）和Lucid，Inc。合作，提议调查使用合并的反射式共透明显微镜 - 极化敏感的光学光学光学相干术（RCM-PSOCT）对皮肤诊断的In Vivo诊断。 RCM和OCT都是强大的技术，在人类皮肤成像中获得了可证明的成功。尽管RCM在浅表皮肤中提供具有核水平分辨率的EN脸部图像，而深度约为200 mm，而OCT在较深的皮肤层中提供了具有结构水平分辨率的横截面图像，至少为1 mm。此外，PSOCT测量皮肤双折射，因此可以准确区分皮肤和表皮皮肤层。因此，这两种光学技术的互补功能可能被利用，以提供临床上全面的诊断参数集，这些参数都无法本身提供：癌症的存在和横向传播，皮肤表皮交界处的位置和入侵阶段的位置。因此，该技术可以帮助临床医生对可疑皮肤病变提供更可靠的诊断，并显着减少不必要的活检数量。为了对这种强大的双模式成像方法进行初步研究，提出了一种新型的皮肤表皮（DE）交界的新方法。在第一阶段，我们建议开发一种将RCM和PSOCT结合在同一光学布局中的台式仪器。该仪器的初步测试将在切除的组织标本和几位志愿者的正常皮肤上进行。根据第一阶段的结论，将在II期研究期间，在临床环境中建立和测试该仪器，并在临床环境中建立和测试临床原型。公共卫生相关性：反射率共聚焦显微镜和光学相干断层扫描是在微米量表水平上对生物组织进行成像的强大光学成像技术。这些技术与综合显微镜的组合将使具有高灵敏度和特异性的皮肤癌的非侵入性和实时筛查和诊断，因此可以显着减少不必要的活检的数量。除了消除情绪成本和患者不适之外，这项技术还可以通过消除不必要的活检来大大降低美国的医疗保健成本。