Multicenter Osteoarthritis Study (MOST) Renewal

多中心骨关节炎研究 (MOST) 更新

• 批准号: 8111731
• 负责人: Cora E Lewis
• 金额: $ 74.35万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8111731
• 关键词: Address; Affect; Age; Aging; Arthritis; Ascorbic Acid; Biochemical Genetics; Biological Markers; Biomechanics; Bone Density; Bone Marrow; Cartilage; Chronic Disease; Clinical; Communities; DNA; Degenerative polyarthritis; Development; Disease; Edema; Elderly; Epidemiologic Studies; Equilibrium; Evaluation of Risk Factors; Female; Fracture; Frequencies; Future; Gender; General Population; Goals; Grant; Growth; Image; Incidence; Intake; Interview; Investigation; Joints; Knee; Knee Injuries; Knee Osteoarthritis; Knee joint; Lesion; Longitudinal Studies; Magnetic Resonance Imaging; Mechanics; Medical; Modality; Modification; Muscle Weakness; Musculoskeletal; Neurologic; Nutritional; Obesity; Observational Study; Operative Surgical Procedures; Outcome; Overweight; Pain; Pathology; Persons; Physical activity; Population; Prevalence; Prevention; Prevention strategy; Preventive Intervention; Progressive Disease; Proprioception; Public Health; Reading; Recording of previous events; Recruitment Activity; Reporting; Research Personnel; Risk; Risk Factors; Roentgen Rays; Sampling; Sampling Studies; Series; Serum; Source; Specimen; Staging; Structure; Symptoms; Techniques; Telephone; Testing; Time; Urine; Vitamin D; Vitamin E; Walking; Woman; aged; base; bone; burden of illness; cohort; disability; disorder prevention; disorder risk; effective therapy; experience; falls; follow-up; functional loss; high risk; men; micronutrient deficiency; modifiable risk; novel strategies; operation; population based; prevent; programs; quadriceps muscle; soft tissue

Osteoarthritis (OA) is the most common form of arthritis and disease in the knee is a leading cause of disability. Most epidemiologic studies of knee OA have focused on radiographic disease, but symptomatic OA should be a major focus of studies on preventing OA, because symptomatic disease causes disability and has formidable societal and public health impacts. OA is potentially preventable, but only a limited number of mostly nonmodifiable risk factors has been identified, even though modifiable risk factors such as particularactivities, muscle weakness, proprioceptive deficits, micronutrient deficiencies and structural factors have been proposed and may affect substantiallythe risk of disease. Prevention opportunities are most relevant and are most likely to be used by those who already have disease or who are at highest risk of getting it. This proposal introduces four new approaches into the epidemiologic study of knee osteoarthritis: La focus on symptomatic disease, 2. a comprehensive evaluation of risk factors including modifiable ones, 3. a focus on those who would really benefit from prevention opportunities, those who already have disease or those who are at high risk of getting it and 4. the incorporation of more comprehensive and reproducible imaging than has previously been used including, state of the art radiographic techniques and MRI. MRI provides rich information on structural factors in which abnormalities may affect the risk of disease. The overall objective of this study is to evaluate longitudinally the effects of three groups of factors: biomechanical factors (squatting.kneeling, stair climbing, quadriceps weakness and proprioceptive deficits), bone and structural factors (bone density,bone marrow and meniscal lesions on MRI) and micronutrient deficiencies (vitamin C, E and D) on the occurrence and progression of symptomatic and radiographic knee OA in a population- based sample of men and women aged 50 to 79. We propose to recruit a community-based sample of 3,000 men and women likely to either have knee OA or be at high risk of OA. High risk groups will include those who are overweight, those with knee symptoms or those with a history of knee injuries or operations. Subjects will be evaluated with symptom questionnaires, radiographs and MRI's and will be followed 36 months for the development or progression of symptomatic or radiographic OA. Analyses will focus on the relation of these important risk factors and OA outcomes. This large, multifaceted and comprehensive study of persons with knee OA, or at high risk of disease, offers to address definitively the relation of potentially important risk factors to the development or progression of a major disabling disease and to provide new insights into disease biology and potential opportunities for prevention. University of Alabama at Birmingham / Division of Preventive Medicine * MT734 1530 3rd Avenue South Birmingham, AL 35294-4410 KEY PERSONNEL. See instructions on Page 11. Use continuation pages as needed to provide the required information in the format shown below. Name Organization Role on Project Cora E. Lewis, MD, MPH 4 Univ. of AL at B'ham School of Medicine Principal Investigator Kenneth Saag, MD,MSc A Univ. of AL at B'ham School of Medicine Co-Investigator James Shikany, DrPH, PA-C A Univ. of AL at B'ham School of Medicine Investigator/Examiner PHS 398 (Rev. 4/98) (Format Page 8) Page 2 HH CC Princips^fcstigator/Program Director (Last, first, middle):^^^^mtJ\^Cora E., M.D., M.S.P.H. Type the name of the principal investigator/program director at the top of each printed page and each continuation page. (For type specifications, see instructions on page 6.) RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description,

骨关节炎（OA）是膝盖中最常见的关节炎和疾病形式，是残疾的主要原因。 大多数膝关节OA的流行病学研究都集中在放射线照相疾病上，但有症状的OA应该是 预防OA的主要研究重点，因为有症状性疾病会导致残疾，并且具有强大的 社会和公共卫生影响。 OA可能是可以预防的，但仅数量有限 尽管可修改的危险因素（例如特殊活性），但已确定了不可修改的危险因素 已经提出了肌肉无力，本体感受缺陷，微量营养素缺陷和结构因素 可能会影响疾病的风险。预防机会是最相关的，最有可能是 被已经患有疾病或有最高风险的人使用。 该建议将四种新方法引入了膝盖骨关节炎的流行病学研究：LA专注于 有症状性疾病，2。对包括可修改的风险因素的全面评估，3。关注这些因素 谁会真正从预防机会中受益，那些已经患有疾病的人或那些 获得它和4的风险。与以前相比，合并更全面和可重复的成像 被使用，包括最先进的射线照相技术和MRI。 MRI提供有关结构的丰富信息 异常可能影响疾病风险的因素。 这项研究的总体目的是纵向评估三组因素的影响： 生物力学因子（蹲下。 和结构因子（MRI上的骨密度，骨髓和半月板病变）和微量营养素缺陷 （维生素C，E和D）关于人群中有症状和射线照相术的发生和进展 基于50至79岁的男女样本。 我们建议招募一个基于社区的样本，分别有3,000名可能有膝盖OA或处于 OA的高风险。高风险组将包括那些超重的人，患有膝盖症状的人或 膝盖受伤或手术的历史。受试者将通过症状调查表，X光片和 MRI的症状或放射线OA的发展或进展将在36个月内进行36个月。 分析将集中于这些重要的风险因素和OA结果的关系。 这项大型，多方面的全面研究对膝盖OA或疾病的高风险提供了 确切地解决潜在重要的风险因素与主要发展或发展的关系 禁用疾病，并提供有关疾病生物学和潜在预防机会的新见解。 阿拉巴马大学伯明翰 / 预防医学司 * MT734 1530 3rd Avenue South 伯明翰，AL 35294-4410 关键人员。请参阅第11页的说明。根据需要使用延续页面来提供所需的信息 以下面显示的格式。 姓名组织角色 Cora E. Lewis，医学博士，MPH 4 Univ。 B'HAM医学院首席研究员AL 医学博士肯尼斯·萨格（Kenneth Saag） B'HAM医学学院共同投资者的AL James Shikany，Drph，Pa-c A 大学。 B'HAM医学学院的AL研究员/考官 PHS 398（修订版4/98）（格式8）第2页HH CC Princips^fcstigator/Program总监（最后，第一，中间）：^^^^ Mtj \^Cora E.，M.D.，M.S.P.H. 在每个打印页面的顶部和每个延续页面的顶部键入主要调查员/计划总监的名称。 （对于类型规格，请参阅 第6页的说明）。 研究赠款 目录 页码 面部第1页 描述，