Animal Facility

动物设施

基本信息

批准号：
8378481
负责人：
JAN S. ERIKSON
金额：
$ 24.26万
依托单位：
WISTAR INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8378481
关键词：
Administrator Air Conditioning American Anesthesia procedures Animal Husbandry Animal Model Animals Back Basic Cancer Research Breeding Cancer Center Cancer Research Project Caring Chills Computer Security Consultations Containment Development Emergency Situation Employee Ensure Environment Environmental air flow Equipment Event Facility Regulation Faculty Failure Future Gene Expression Regulation Genetic Goals Government regulations Hand Health Heating Hemorrhage Hour House mice Housing Human Human Resources IACUC Image Immunology Infectious Agent Information Dissemination Injection of therapeutic agent Instruction Knowledge Laboratory Animal Medicine Laboratory Animal Production and Facilities Laboratory Animal Science Laboratory Animals Maintenance Malignant Neoplasms Medicine Monitor Mus Nature Neoplasm Metastasis Operative Surgical Procedures Pharmacy facility Polishes Principal Investigator Procedures Qualifying Quality of Care Quarantine Regulation Research Research Infrastructure Research Personnel Resolution Rodent Running Safety Security Services Severe Combined Immunodeficiency Surveillance Program System Temperature Testing The Wistar Institute Time Training Transgenic Mice Viral Vector Water Supply Weather angiogenesis animal care animal facility biosafety level 2 facility college digital experience improved in vivo meetings member programs tool tumor growth tumorigenesis

项目摘要

The Wistar Institute provides an AAALAC-accredited Animal Facility that serves faculty from the Gene Expression and Regulation, Oncogenesis, and Immunology Cancer Center programs. The facility is maintained as a modified barrier Biosafety Level 2 (BSL2) facility by highly qualified and experienced personnel. In addition to ordering and housing research animals, the facility houses the Mouse Genetics Facility. The Animal Facility supports the severe combined immunodeficiency (SCID) mouse breeding colony, quarantine housing, technical training, Intravital Imaging System (MS) 200i in vivo imaging capabilities, animal health surveillance, veterinary coverage, new employee hands-on training, and Institutional Animal Care and Use Committee (IACUC) testing. Since 2003, The Wistar Institute has invested over $1 million into the Animal Facility for structural upgrades and new equipment supporting Cancer Center programs. A new polishing chiller augments chilled water supplies for cooling, and ensures stable temperature regulation for the Facility during the hottest weather, as well as back-up chilled water supplies in the event of failure in the primary cooling system. Additional upgrades to the facility infrastructure include improved ventilation, security, and emergency capabilities. Direct Digital Control monitoring has been incorporated into all animal rooms, offering 24-hour monitoring of the temperature as well as the heating, ventilation, and air condition (HVAC) system. Research infrastructure improvements include the addition of an IVIS imager, permitting tumor growth monitoring over time at high resolution; new state-of-the-art biocontainment equipment for expanding studies involving viral vectors and other infectious agents; and a transgenic mouse suite for use by the expanding Mouse Genetics Shared Facility. Future goals reflect the needs of cancer researchers and shared facilities and include the purchase of additional bio-containment caging equipment and Class II bio-safety cabinets; an anesthesia machine; a stereomicroscope for mouse surgical procedures; and continued upgrades to security systems.

Wistar Institute提供了AAAALAC认可的动物设施，该设施为基因的教师提供服务表达和调节，肿瘤发生和免疫学癌症中心计划。设施是通过高素质和经验丰富人员。除了订购和住房研究动物外，该设施还容纳了小鼠遗传学设施。动物设施支持严重的联合免疫缺陷（SCID）小鼠育种殖民地，隔离外壳，技术培训，插入成像系统（MS）200i体内成像能力，动物健康监视，兽医承保范围，新员工动手培训和机构动物护理和使用委员会（IACUC）测试。自2003年以来，维斯塔尔研究所（Wistar Institute）投资了超过100万美元进入动物设施，用于结构升级和支持癌症中心的新设备程序。一种新的抛光冷水机增强冷水供应以进行冷却，并确保稳定在最热的天气期间，该设施的温度调节，以及备用冷藏水供应主要冷却系统失败的事件。设施基础设施的额外升级包括改善通风，安全性和紧急功能。直接的数字控制监控已经纳入所有动物室，提供24小时监测温度以及加热的监测通风和空调（HVAC）系统。研究基础设施的改进包括添加 IVIS成像仪，允许在高分辨率下随着时间的推移进行肿瘤生长监测；新的最先进的生物内在扩展涉及病毒载体和其他传染剂的研究的设备；和转基因小鼠套件可通过扩展的小鼠遗传学共享设备使用。未来的目标反映了癌症研究人员和共享设施的需求，包括购买额外的生物接触笼子设备和II类生物安全柜；麻醉机；小鼠的立体显微镜手术程序；并继续升级到安全系统。