Sensorimotor abnormalities in childhood onset psychotic disorders

儿童期发病的精神障碍中的感觉运动异常

基本信息

批准号：
8464786
负责人：
DONALD C. ROJAS
金额：
$ 32.82万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-06-01 至 2014-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8464786
关键词：
Adolescent Age Area Attention Basal Ganglia Behavior Behavioral Biological Markers Bipolar Disorder Brain Brain region Categories Cerebellum Child Childhood Clinical Control Groups Development Diagnosis Disease Exhibits Failure Family Family Study Family history of Feedback Fingers Frequencies Future Gender Genetic Genetic Risk Goals Ipsilateral Knowledge Lead Life Magnetic Resonance Imaging Magnetoencephalography Measures Methods Metric Mood Disorders Moods Motor Motor Cortex Movement Neurobiology Neurologic Neuronal Dysfunction Onset of illness Participant Patients Performance Phase Psychotic Disorders Public Health Research Risk Factors Schizophrenia Severities Signal Transduction Somatosensory Cortex Structure Structure-Activity Relationship Symptoms Techniques Testing Time base caudate nucleus early childhood feeding improved motor deficit neurobehavioral neuroimaging neurophysiology outcome forecast patient population research study response somatosensory theories treatment planning

项目摘要

PROJECT SUMMARY/ABSTRACT We are requesting support for a study of brain sensorimotor abnormalities in childhood onset psychotic illnesses. Motor deficits are consistently found in psychotic patient populations and have also been identified as among a few promising early childhood risk factors for psychosis. We will employ a combination of neurobehavioral methods with non-invasive neuroimaging using magnetoencephalography (MEG) and structural magnetic resonance imaging (MRI). Eighty young participants with either childhood onset psychotic bipolar disorder (N=40) or schizophrenia (N=40) will be compared to age and gender matched comparison subjects (N=40) without personal or family history of psychotic and/or bipolar mood disorders. Our general perspective on motor coordination deficits is two-fold. First, we propose that a failure in inter-hemispheric motor inhibition results in failures to properly coordinate timing signals in bimanual coordination. Second, we believe that a failure in feed-forward efferent copy mechanisms from motor to somatosensory cortex results in improper perceptual feedback during patient's own movements. Our long term goals for this research are to refine the neurobiology of motor deficits in psychotic disorders, develop biomarkers for future family-based studies of genetic risk and evaluate neurobiological differences between schizophreniform and mood-related psychotic illnesses. Some of these biomarkers should be associated with psychosis per se and others with more disorder specific clinical manifestations. Such knowledge could a) contribute to earlier and more accurate diagnosis, b) lead to improved treatment planning at onset of illness, c) assist with more accurate estimate of illness trajectory and prognosis, d) aid in the development of possible new endophenotypic markers for psychosis, and e) form the basis for future family studies relating to genetic vs. developmental contributions to these disorders.

项目摘要/摘要我们要求支持童年发作中脑感觉运动异常的研究疾病。运动缺陷始终在精神病患者人群中发现，也已被发现在一些有希望的精神病幼儿危险因素中。我们将采用组合使用磁脑电图（MEG）和非侵入性神经影像学（MEG）和结构磁共振成像（MRI）。八十名童年发作的年轻参与者精神病将躁郁症（n = 40）或精神分裂症（n = 40）与年龄和性别匹配的比较进行比较受试者（n = 40）没有精神病和/或双相情绪障碍的个人或家族史。我们的将军运动协调缺陷的观点是两个方面。首先，我们提出了半球间的失败运动抑制会导致在双层协调中正确协调时间信号的失败。第二，我们认为从电动机到体感皮质的饲料前辐射副本机制失败导致在患者自己的运动中，不正确的感知反馈。我们这项研究的长期目标是完善精神疾病中运动缺陷的神经生物学，为将来的基于家庭的生物标志物开发遗传风险的研究并评估精神分裂和情绪相关的神经生物学差异精神病疾病。这些生物标志物中的一些应与精神病本身有关，而其他生物标志物应与更具体的临床表现。这样的知识可以a）促进早期以及更多的贡献准确的诊断，b）导致疾病发作时改善治疗计划，c）更准确地协助疾病轨迹和预后的估计，d）有助于开发可能的新内向型型精神病的标记，e）构成与遗传与发展有关的未来家庭研究的基础对这些疾病的贡献。