Evaluating a novel working memory training program to decrease symptoms of PTSD

评估一种新的工作记忆训练计划以减少 PTSD 症状

基本信息

批准号：
8369868
负责人：
Jessica Bomyea
金额：
$ 3.04万
依托单位：
SAN DIEGO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-01-01 至 2013-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8369868
关键词：
Accounting Affect Aftercare Amber American American Psychiatric Association Amygdaloid structure Anxiety Applications Grants Area Attention Award Biometry Burn injury Characteristics Chronic Clinical Research Cognition Cognitive Cognitive Science Cognitive deficits Complement Computers Disease Distress Educational process of instructing Emotional Event Extinction (Psychology)Fright Functional Magnetic Resonance Imaging Future Generalized Anxiety Disorder Generations Goals Individual Intervention Interviewer Knowledge Laboratories Laboratory Research Lead Learning Length Life Link Literature Maintenance Mediating Memory Mental Depression Methodology Methods Modification Monitor National Institute of Mental Health Neurobiology Obsessive-Compulsive Disorder Participant Patient Self-Report Performance Pharmacological Treatment Play Post-Traumatic Stress Disorders Preparation Procedures Process Program Effectiveness Publications Randomized Relative (related person)Reporting Research Research Training Role Secondary to Short-Term Memory Social Phobia Stimulus Strategic Planning Symptoms Task Performances Testing Theoretical model Thinking Training Training Programs Training Technics Trauma Treatment outcome Update Woman Work base career cognitive control cognitive training cost cost effective depressive symptoms design disorder control economic cost effective therapy executive function experience health care service utilization improved innovation neural circuit neuropsychological novel novel strategies operation primary outcome programs psychosocial public health relevance response secondary outcome sexual assault skills social suicidal risk

项目摘要

DESCRIPTION (provided by applicant): Post-traumatic stress Disorder (PTSD) is a chronic and debilitating disorder that affects millions of people each year (Kessler et al., 2005). Although effective psychosocial and pharmacological treatments exist for this disorder, as many as 50 percent of individuals still experience symptoms after treatment (Schottenbaeur et al., 2008). Empirical literature suggests that cognitive deficits may play a role in maintaining symptoms in individuals with PTSD through a variety of mechanisms, including decreased cognitive control over intrusive thoughts (Verwoerd et al., in press) and dysregulation in neural circuitry linking prefrontal cognitive control functions and amygdala activity (McNally, 2007). The goals of the proposed research are to improve the candidate's understanding of cognitive mechanisms of PTSD symptoms while building skills in conducting treatment research. The application aims to test a novel methodology for approaching PTSD treatment based on modification of underlying cognitive mechanisms of the disorder. To this end, 50 participants with PTSD will be randomly assigned to an 8-session executive control training condition designed to improve working memory functioning or a control condition. The aims of this study are 1) To test the effect of a working memory training program on working memory performance and 2) To examine the effects of this program on PTSD symptoms. The research plan is complemented by a set of training goals for the candidate to achieve over the proposed award period. These include 1) training in the use of fMRI and neuropsychological assessment 2) additional coursework and seminars in cognitive science and biostatistics for use in future work, 3) experience with teaching in the undergraduate and graduate setting and presenting original work for publication in preparation for a career in academic research. Taken together, the research and training components of this grant application will facilitate the candidate's long-term goal of conducting treatment outcome and basic mechanism research in PTSD. Moreover, as per the strategic plan outlined by NIMH, this application is designed develop an innovative intervention based on prior clinical research and knowledge of cognitive and neurobiological features of the disorder, and will advance knowledge of mechanisms of fear learning. It is designed to target core cognitive features of the disorder in an effort to reduce symptoms.

描述（由申请人提供）：创伤后应激障碍（PTSD）是一种慢性且使人衰弱的疾病，每年影响数百万人（Kessler 等，2005）。尽管针对这种疾病存在有效的心理社会和药物治疗，但多达 50% 的人在治疗后仍会出现症状（Schottenbaeur 等，2008）。经验文献表明，认知缺陷可能通过多种机制在维持 PTSD 个体的症状方面发挥作用，包括对侵入性思想的认知控制能力下降（Verwoerd 等人，正在出版）以及连接前额认知控制功能和认知功能的神经回路失调。杏仁核活动（McNally，2007）。拟议研究的目标是提高候选人对 PTSD 症状认知机制的理解，同时培养进行治疗研究的技能。该应用程序旨在测试一种基于改变该疾病的潜在认知机制来治疗 PTSD 的新方法。为此，50 名患有 PTSD 的参与者将被随机分配到为期 8 节的执行控制训练条件，旨在改善工作记忆功能或控制条件。本研究的目的是 1) 测试工作记忆训练计划对工作记忆表现的影响；2) 检查该计划对 PTSD 症状的影响。该研究计划还辅以一系列培训目标，供候选人在拟议的奖励期内实现。其中包括 1) 使用功能磁共振成像和神经心理学评估的培训 2) 认知科学和生物统计学方面的额外课程和研讨会，供未来工作使用，3) 本科生和研究生教学经验以及为出版做准备的原创作品的经验从事学术研究的职业。总而言之，本次拨款申请的研究和培训部分将有助于候选人实现创伤后应激障碍治疗结果和基本机制研究的长期目标。此外，根据 NIMH 概述的战略计划，该应用程序旨在基于先前的临床研究以及对该疾病的认知和神经生物学特征的了解来开发创新干预措施，并将增进对恐惧学习机制的了解。它旨在针对该疾病的核心认知特征，以减轻症状。