PRCTRC

中华人民共和国TRC

• 批准号: 8359914
• 负责人: WALTER R. FRONTERA
• 金额: $ 83.16万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359914
• 关键词: Affect; Area; Biometry; Cardiovascular system; Clinical; Clinical Research; Collaborations; Communities; Development; Disease; Funding; Goals; Grant; HIV; Health; Healthcare; Institution; Knowledge; Laboratories; Leadership; Malignant Neoplasms; Mentors; Minority; Minority Groups; National Center for Research Resources; Neurosciences; Participant; Population; Principal Investigator; Puerto Rico; Research; Research Infrastructure; Research Personnel; Resource Informatics; Resources; Source; Structure; Technology; Training; Translational Research; Underrepresented Minority; United States National Institutes of Health; cost; data management; disorder prevention; health disparity; knowledge translation; multidisciplinary; novel; patient oriented research; programs; public health relevance

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. There is an urgent need for reducing or eliminating many health disparities that affect underserved minority populations. Despite important advances in knowledge about the basic mechanisms of disease, translation of this knowledge to treatment and prevention of disease has been limited and slow, in particular for these underserved ethnic and racial minorities. The Puerto Rico Clinical and Translational Research Consortium (PRCTRC) will be established as the concept that will advance this translation of knowledge and have an impact on these disparities. It will be a centralized clinical and translational research program focused on health problems prevalent in an underserved minority population and establishing a multidisciplinary and collaborative effort between three major academic health care institutions in Puerto Rico. The major programmatic goals are to: 1) To enhance and integrate existing infrastructure for clinical and translational research to support and expand Clinical and Translational Research in the Health Disparities; 2) To enhance and support existing training and mentoring programs to increase the number of new minority investigators in Clinical and Translational Research; 3) To facilitate the translation of knowledge from the bench into the community. To accomplish these goals we will integrate, expand and enhance: 1) Participant and Clinical Interaction Resources 2) Clinical and Translational Research core resources in Biostatistics and Data Management 3) Core laboratories and technologies 4) Training and developmental programs 5) Support for regulatory compliance resources 6) Informatic resources 7) Community interactions and participation programs. The proposed program will be integrative, incorporating resources and leadership from all three institutions, many of these under the RCMI-Clinical Research Center (RCMI-CRC) and the Comprehensive Center for Health Disparities (CCHD) but fusing under a single administrative structure. The proposed program will be inclusive, incorporating leadership from all the participating institutions at several levels of administrative responsibility. It will be novel, because it will provide a unique opportunity to incorporate resources and have an impact across a state-size territory composed primarily of a minority population. The PRCTRC will focus on four scientific areas: cancer, cardiovascular, HIV, neuroscience. PUBLIC HEALTH RELEVANCE: The proposed program will help advance knowledge about conditions that disproportionately affect minority populations and will provide a platform for more efficient collaborations among institutions that serve these populations. By enhancing and consolidating existing resources it will facilitate the discovery of new knowledge in patient-oriented research and will aid in the development of new, clinical and translational minority researchers.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 迫切需要减少或消除影响服务不足的少数群体的许多健康差异。尽管有关疾病基本机制的知识取得了重要进展，但将这些知识转化为疾病的治疗和预防仍然有限且缓慢，特别是对于这些服务不足的民族和少数族裔而言。 波多黎各临床和转化研究联盟（PRCTRC）的成立将作为推进知识转化并对这些差异产生影响的概念。这将是一个集中的临床和转化研究计划，重点关注服务不足的少数族裔中普遍存在的健康问题，并在波多黎各三个主要学术医疗保健机构之间建立多学科和协作努力。 主要计划目标是： 1) 加强和整合现有的临床和转化研究基础设施，以支持和扩大健康差异方面的临床和转化研究； 2) 加强和支持现有的培训和指导计划，以增加临床和转化研究中新的少数族裔研究者的数量； 3) 促进将知识从实验室转化为社区。为了实现这些目标，我们将整合、扩展和增强：1) 参与者和临床互动资源 2) 生物统计学和数据管理方面的临床和转化研究核心资源 3) 核心实验室和技术 4) 培训和发展计划 5) 对法规遵从性的支持资源 6) 信息资源 7) 社区互动和参与计划。拟议的计划将是综合性的，整合了所有三个机构的资源和领导力，其中许多机构隶属于 RCMI 临床研究中心 (RCMI-CRC) 和健康差异综合中心 (CCHD)，但融合在一个单一的管理结构下。拟议的计划将具有包容性，包括所有参与机构在多个行政责任级别的领导。它将是新颖的，因为它将提供一个独特的机会来整合资源并对主要由少数族裔人口组成的州级领土产生影响。 PRCTRC 将重点关注四个科学领域：癌症、心血管、艾滋病毒、神经科学。 公共卫生相关性：拟议的计划将有助于增进对对少数族裔人口影响尤为严重的状况的了解，并将为服务这些人口的机构之间更有效的合作提供一个平台。通过增强和整合现有资源，它将促进以患者为导向的研究中新知识的发现，并有助于培养新的临床和转化少数研究人员。