Magnetic Resonance Elastography

磁共振弹性成像

• 批准号: 8435481
• 负责人: Richard L. Ehman
• 金额: $ 32.16万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-05 至 2015-12-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8435481
• 关键词: Abdomen; Accounting; Acoustics; Adrenal Glands; Affect; Algorithms; Anisotropy; Biological Markers; Biopsy; Body Regions; Breast; Cancer Detection; Characteristics; Clinical; Clinical Research; Computer software; Data Reporting; Data Set; Detection; Development; Device or Instrument Development; Diagnosis; Diagnostic; Diagnostic Imaging; Diagnostic Procedure; Diffuse; Disease; Engineering; Evaluation; Frequencies; Goals; Grant; Hand; Health; Hepatic; Image; Imaging Device; Imaging Techniques; Imaging technology; Investigation; Kidney; Lesion; Lighting; Liver; Liver diseases; Magnetic Resonance Elastography; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Mechanics; Methods; Modeling; Motion; Normal tissue morphology; Organ; Palpation; Pancreas; Patients; Pattern; Pelvis; Performance; Phase; Physicians; Physiologic pulse; Process; Property; Prostate; Protocols documentation; Reproducibility; Research; Resolution; Rheology; Role; Science; Small Intestines; Specimen; System; Techniques; Technology; Testing; Time; Tissue Model; Tissues; Touch sensation; Training; Ultrasonography; Update; Uterus; Venous Pressure level; Work; X-Ray Computed Tomography; animal tissue; base; chronic liver disease; clinical application; design; disease diagnosis; elastography; flexibility; human tissue; imaging modality; improved; in vivo; mathematical algorithm; motion sensitivity; new technology; novel; novel diagnostics; prototype; public health relevance; response; thyroid neoplasm; tool; tumor; volunteer

DESCRIPTION (provided by applicant): Many disease processes are characterized by substantially different mechanical properties than surrounding normal tissue. This accounts for the efficacy of palpation as a clinical technique to detect cancer and other abnormalities. Indeed, many tumors of the thyroid, breast, and prostate are still first detected by this centuries- old diagnostic technique. Unfortunately, palpation is a subjective technique and small or inaccessible abnormalities cannot be detected by touch. Conventional imaging methods such as ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) do not provide information that is in any way analogous. The goal of this research is to develop, validate, explore and identify high-impact applications of a new diagnostic imaging technology for quantitatively assessing the mechanical properties of tissues. We call this technique Magnetic Resonance Elastography (MRE). Mechanical waves are generated in tissue and a remarkably sensitive phase-contrast MRI technique, using synchronous motion-sensitizing gradients, is used to directly image the pattern of wave propagation. Specially-developed mathematical algorithms are used to analyze the wave images and to generate quantitative images depicting the stiffness and other mechanical properties of tissue. At the onset of this research, the central hypothesis was that MRE can be successfully implemented as a practical scientific and clinical tool and that it would be useful for detecting and characterizing focal and diffuse disease processes that may be difficult to investigate by other methods. The research in the last cycle of this grant has confirmed this hypothesis by developing, validating, and introducing into clinical research an MRE- based technique for diagnosing chronic liver disease. The research has indicated that in this role, MRE is a more-comfortable, safer, less-expensive alternative to biopsy. The research plan for the next grant cycle includes investigations to further understand and develop the underlying technology of MRE, to develop practical methods for applying other applications, and to explore promising new applications in diagnosing disease. The research plan involves theoretical work, basic MRI pulse sequence development, device engineering, studies of animal and human tissue specimens, and protocol testing studies with normal and patient volunteers. Further progress is expected to provide an increasingly useful imaging tool with capabilities to: (1) noninvasively "palpate by imaging" regions of the body that are beyond the reach of the physician's hand, (2) delineate tumors and other abnormalities before they are severe enough to detect by touch, (3) provide greater sensitivity for assessing changes in tissue mechanical properties, and (4) provide useful new quantitative imaging biomarkers for characterizing tissue properties.

描述（由申请人提供）：许多疾病过程的特征是与周围正常组织的机械特性实质上不同。这说明了触诊作为一种检测癌症和其他异常的临床技术的功效。实际上，这种旧的诊断技术仍然首先检测到甲状腺，乳房和前列腺的许多肿瘤。不幸的是，触诊是一种主观技术，无法通过触摸检测到小或难以及的异常。传统的成像方法，例如超声，计算机断层扫描（CT）和磁共振成像（MRI）均未提供任何类似方式的信息。这项研究的目的是开发，验证，探索和确定新的诊断成像技术的高影响应用，以定量评估组织的机械性能。我们称此技术磁共振弹性图（MRE）。机械波是在组织中产生的，使用同步运动敏化梯度的一种非常敏感的相对比对比度MRI技术用于直接成像波传播的模式。专门发达的数学算法用于分析波浪图像并生成描述组织的刚度和其他机械性能的定量图像。在这项研究开始时，中央假设是可以成功实施MRE作为一种实用的科学和临床工具，并且对于检测和表征局灶性和弥漫性疾病过程将很有用，这些过程可能难以通过其他方法进行研究。该赠款最后一家周期中的研究通过开发，验证和引入临床研究来证实了这一假设，用于诊断慢性肝病的基于MRE的技术。研究表明，在这一角色中，MRE是一种更加舒适，更安全，廉价的活检替代品。下一个赠款周期的研究计划包括调查，以进一步理解和开发MRE的潜在技术，开发用于应用其他应用的实用方法，并探索有希望的诊断疾病中有希望的新应用。该研究计划涉及理论工作，基本MRI脉冲序列开发，设备工程，动物和人体组织样品研究以及与正常和患者志愿者的协议测试研究。预计进一步的进步将提供一种具有功能的越来越有用的成像工具：（1）无创的“通过成像触诊”身体超出了医生手的范围，（（2）肿瘤和其他异常性和其他异常性和其他异常性，然后它们在触摸时足够严重，以提供更大的敏感性，以评估量化的敏感性（3）（3）4（3）4（3）（3）4（3）4（3）4（3）4表征组织特性。