The Ohio State University Center for Clinical and Translational Science (UL1)

俄亥俄州立大学临床与转化科学中心 (UL1)

• 批准号: 8665544
• 负责人: REBECCA D JACKSON
• 金额: $ 239.79万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-19 至 2013-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8665544
• 关键词: Behavioral Research; Biomedical Research; Biometry; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; County; Dentistry; Diffusion; Discipline; Discipline of Nursing; Ethics; Faculty; Healthcare Systems; Home environment; Hospitals; Informatics; Institutes; Knowledge; Laboratories; Link; Medicine; Modeling; Ohio; Optometry; Participant; Patients; Pediatric Hospitals; Pharmacy facility; Primary Health Care; Process; Public Health; Quality of Care; Research; Research Activity; Research Design; Research Infrastructure; Research Personnel; Research Support; Resources; Science; Services; Technology; Training; Training Support; Translating; Translational Research; Translations; Universities; Veterinary Medicine; Work; biological research; career; career development; college; design; disorder prevention; health science research; human subject protection; improved; innovation; meetings; multidisciplinary; novel; programs; tool

Despite significant advances in basic scientific discovery, new clinical research initiatives and a faculty of talented investigators and clinicians, the translation of new knowledge to meaningful improvements in treatment and disease prevention has been slow. In meeting this challenge, The Ohio State University has established The Center for Clinical and Translational Science (OSU CCTS) to improve the quality of care for all patients in the community by creating a transformative clinical and translational science discipline that is at the core of the OSU academic culture. The Center will accomplish four specific aims: 1) create an "academic home" for clinical and translational science; 2) enhance and nurture the career development of a cadre of highly trained, interdisciplinary investigators; 3) enhance, develop and integrate the infrastructure to support research design of exemplary, novel and responsive clinical and translational research; 4) enhance, develop and integrate the resources and tools necessary for clinical and translational research implementation including a focus on developing resources to translate the research into the community. This new center will focus on integrating the traditional biomedical research process with a public health model. The Center will provide programs to support the efforts of investigators to engage in multidisciplinary team- science with career support and training opportunities; efficient and effective participant and clinical interactions resources; enhanced relevance and diffusion of health sciences research with the community; a cohesive and collaborative informatics infrastructure capable of supporting team-science and increased translational capacity; efficient and effective design, biostatistics and ethics support for investigators; regulatory support for research teams promoting the protection-of human subjects-and-facilitatingregulatory compliance; capability to complete and disseminate pilot and other novel research efforts; and core resources and services, including advanced state-of-the-art technologies. The OSU CCTS will involve faculty and resources from the Colleges of Dentistry, Medicine, Nursing, Optometry, Pharmacy, Public Health and Veterinary Medicine and other OSU colleges, centers and institutes that are engaged in clinical and translational research activities. It will support a robust and integrated partnership between OSU and Columbus Children's Hospital and will link these sophisticated 'health care systems as a laboratory for biological, clinical and behavioral research. By also working through affiliated hospital networks, the primary care network and Extension offices in all 88 counties in Ohio, the OSU CCTS will allow clinical and translational research to be done in innovative collaboration with the community.

尽管基本科学发现取得了重大进步，新的临床研究计划和 才华横溢的研究人员和临床医生，将新知识转化为有意义的改进 治疗和预防疾病一直很慢。在满足这一挑战时，俄亥俄州立大学有 建立了临床和转化科学中心（OSU CCTS），以提高护理质量 社区中的所有患者都通过创建一种变革性的临床和转化科学纪律是 OSU学术文化的核心。该中心将完成四个具体目标：1）创建一个 临床和转化科学的“学术主页”； 2）增强和培养职业发展 训练有素的跨学科研究人员的干部； 3）增强，开发和集成基础架构 支持示例性，新颖和响应式临床和转化研究的研究设计； 4）增强， 开发和整合临床和转化研究所需的资源和工具 实施包括专注于开发资源以将研究转化为社区。这 New Center将专注于将传统的生物医学研究过程与公共卫生模型相结合。 该中心将提供计划，以支持调查人员参与多学科团队的努力 - 具有职业支持和培训机会的科学；高效有效的参与者和临床 互动资源；健康科学研究的相关性和扩散与社区的扩散；一个 能够支持团队科学并增加的凝聚力和协作信息学基础架构 翻译能力；为研究人员提供高效有效的设计，生物统计学和道德支持； 对促进人类受试者和基础调节的研究团队的监管支持 遵守;能够完成和传播其他新型研究工作的能力；和核心 资源和服务，包括先进的最新技术。 OSU CCT将涉及教师 以及牙科，医学，护理，验光，药房，公共卫生和 兽医医学以及其他从事临床和研究学院 翻译研究活动。它将支持OSU和 哥伦布儿童医院，并将这些复杂的“医疗保健系统”联系起来 生物学，临床和行为研究。通过通过关联医院网络工作，主要 俄亥俄州所有88个县的护理网络和扩展办公室，OSU CCT将允许临床和 转化研究将与社区创新合作。

项目成果

A Pilot Randomized Controlled Trial Using SystemCHANGE™ Approach to Increase Physical Activity in Older Kidney Transplant Recipients.

• DOI: 10.1177/1526924820958148
• 发表时间: 2020-12
• 期刊: Progress in transplantation (Aliso Viejo, Calif.)
• 作者: O'Brien T;Russell CL;Tan A;Mion L;Rose K;Focht B;Daloul R;Hathaway D
• 通讯作者: Hathaway D

Cervical spondylomyelopathy in Great Danes: a magnetic resonance imaging morphometric study.

• DOI: 10.1016/j.tvjl.2014.04.011
• 发表时间: 2014-07
• 期刊: Veterinary journal (London, England : 1997)
• 作者: Martin-Vaquero P;da Costa RC;Lima CG
• 通讯作者: Lima CG

Hypoglycaemia in hospitalized patients with or without heart failure.

患有或不患有心力衰竭的住院患者的低血糖。

• DOI: 10.1111/dom.13376
• 发表时间: 2018
• 期刊: Diabetes, obesity & metabolism
• 作者: Merrill,JenniferD;Dungan,KathleenM
• 通讯作者: Dungan,KathleenM

Federated Aggregate Cohort Estimator (FACE): an easy to deploy, vendor neutral, multi-institutional cohort query architecture.

联合聚合群组估计器 (FACE)：一种易于部署、供应商中立、多机构群组查询架构。

• DOI: 10.1016/j.jbi.2013.11.009
• 发表时间: 2014
• 期刊: Journal of biomedical informatics
• 影响因子: 4.5
• 作者: Wyatt,MatthewC;Hendrickson,RCurtis;Ames,Michael;Bondy,Jessica;Ranauro,Paul;English,ThomasM;Bobitt,Keith;Davidson,Arthur;Houston,ThomasK;Embi,PeterJ;Berner,EtaS
• 通讯作者: Berner,EtaS

Associations Between Movement Impairments and Function, Treatment Recommendations, and Treatment Plans for People With Femoroacetabular Impingement Syndrome.

股骨髋臼撞击综合征患者运动障碍与功能之间的关联、治疗建议和治疗计划。

• DOI: 10.1093/ptj/pzab157
• 发表时间: 2021
• 期刊: Physical therapy
• 影响因子: 3.2
• 作者: Brown-Taylor,Lindsey;Pendley,Chase;Glaws,Kathryn;Vasileff,WKelton;Ryan,John;Harris-Hayes,Marcie;DiStasi,StephanieL
• 通讯作者: DiStasi,StephanieL