Training Program in Cancer Biology

癌症生物学培训计划

• 批准号: 8291409
• 负责人: Stuart A Aaronson
• 金额: $ 75.15万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-20 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8291409
• 关键词: Cancer Biology; Training Programs

Seeinstructions): The Mount Sinai School of Medicine (MSSM) proposes to continue a highly successful Cancer Biology training program for predoctoral fellows and postdoctoral fellows. This program reflects a major expansion of cancer research at MSSM, which has experienced 2.5-fold growth in NCI funding since initiation of this program almost a decade ago. Its leadership has extensive experience in cancer research mentoring and a well-documented commitment to graduate education and training. This NCI Training Program catalyzed the recent establishment of Cancer Biology as a formal training area within the Graduate School. The program encompasses a laboratory-based, multidisciplinary program in cancer biology with a growing and dynamic faculty. Five predoctoral trainees would continue to be supported by the training program, which has demonstrated the ability to attract and develop a cadre of outstanding PhD and MD/PhD students in cancer focused research. The postdoctoral component of this program, which is completing its first cycle, also attracts outstanding trainees. We propose to merge our more translationally focused NCI training program, which had 5 positions, with the current basic research focused component possessing 5 positions. In this renewal application, we request 8 postdoctoral positions in the first year with incremental increases to 10 training positions. This administrative consolidation should foster even greater interactions between laboratory trainees and those clinical fellows, who embark on a period of intensive laboratory research within this program. The training faculty comprises 40 preceptors from 9 departments and 4 Institutes throughout Mount Sinai. Of these faculty, 63% have peer-reviewed support from funding agencies for cancer-related studies. The curriculum for the predoctoral and postdoctoral trainees involves some common elements including advanced course work in both basic and clinical cancer biology. All trainees also participate in regular conferences, which further expose trainees to clinical aspects of cancer. There are important specific training elements for each component as well. There is a rigorous evaluation and selection process, and-the program is both cognizant of and actively involved in minority recruitment. This training program combines research in the biology of cancer with a curriculum that challenges trainees to consider how their research may be translated into improvements in the diagnosis and treatment of cancer. The trainees work closely with faculty drawn from throughout Mount Sinai ensuring that this research is both comprehensive in scope and related to practical issues faced by physicians in preventing and treating cancer. RELEVANCE (See instructions!: Cancer biology research within this training program is aimed at elucidating the molecular mechanisms responsible for initiation and progression of human cancer as well as research directly aimed at improving the ability to treat this terrible disease. Our training faculty has made discoveries that have led to new therapies for cancer, which is responsible for extensive morbidity and more than 560,000 expected deaths in 2008 in the United States.

see Instructions）： 西奈山医学院（MSSM）建议继续非常成功的癌症生物学 培训计划和博士后研究员的培训计划。该程序反映了 MSSM的癌症研究，自此以来，NCI资金的增长率为2.5倍 计划大约十年前。它的领导领导在癌症研究指导和 有据可查的致力于研究生教育和培训的承诺。这个NCI培训计划催化了 最近将癌症生物学作为研究生院内的正式培训领域。该程序 涵盖了一个基于实验室的多学科生物学的多学科计划，并具有增长和动态 学院。培训计划将继续支持五名五名学员 展示了吸引和发展癌症中出色的博士和医学博士学位学生的干部 集中研究。该程序的博士后组件正在完成其第一个周期，也是 吸引出色的学员。我们建议合并我们更注重翻译的NCI培训计划， 该职位有5个职位，目前的基础研究集中在具有5个职位。在这个 续订申请，我们在第一年要求8个博士后职位，增量增加到10 训练位置。这种行政合并应促进更多的互动 实验室学员和那些临床研究员，他们在内部进行了一项密集实验室研究的时期 这个程序。培训教师包括来自9个部门和4个机构的40个受体 西奈山。在这些教职员工中，有63％的人对与癌症有关的资助机构进行了同行评审的支持 研究。专业和博士后学员的课程涉及一些共同的元素 包括基本和临床癌症生物学的高级课程工作。所有学员也参加 常规会议，将学员进一步暴露于癌症的临床方面。有重要的特定 每个组件的培训元素也是如此。有一个严格的评估和选择过程，以及 计划既认识并积极参与少数族裔招募。该培训计划结合了 癌症生物学研究的研究，其课程挑战受训者考虑如何研究 可以转化为癌症诊断和治疗的改善。学员紧密工作 西奈山（Mount Sinai）的教职员工确保了这项研究的范围全面 并且与医生在预防和治疗癌症方面面临的实际问题有关。 相关性（请参阅说明！： 该培训计划中的癌症生物学研究旨在阐明分子机制 负责人类癌症的启动和发展以及直接旨在改善的研究 治疗这种可怕疾病的能力。我们的培训学院已经发现了导致新的发现 癌症的疗法，该疗法负责广泛的发病率，预期死亡超过56万 2008年在美国。