Collaborative Observational Study of Myopia in COMET Children (COSMICC2)-UH

COMET 儿童近视协作观察研究 (COSMICC2)-UH

• 批准号: 8204641
• 负责人: RUTH E MANNY
• 金额: $ 27.81万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8204641
• 关键词: 11 year old; 16 year old; 17 year old; 7 year old; Address; Adolescent; Adult; African American; Age; Blindness; Chairperson; Child; Clinical; Cohort Studies; Cornea; Data; Development; Enrollment; Environmental Risk Factor; Ethnic Origin; Eye; Future; Genetic; Grant; Growth; High Prevalence; Hispanics; Hour; Individual; Intervention; Learning; Literature; Measurement; Modeling; Myopia; Observational Study; Occupational; Operative Surgical Procedures; Parents; Participant; Pathology; Physiologic Intraocular Pressure; Population; Predictive Factor; Protocols documentation; Public Health; Recruitment Activity; Refractive Errors; Risk; Risk Factors; Subgroup; Testing; Thick; Time; Vision; Work; age group; base; cohort; follow-up; macula; predictive modeling

DESCRIPTION (provided by applicant): This proposal is for the Houston Clinical Center to continue to annually examine the 116 currently enrolled COSMICC participants (only 2 subjects have withdrawn since recruited in 97-98) at the Houston center for an additional 5 yrs (total follow-up, 14 yrs) following the COSMICC2 protocol. The data collected from this center will be used to address specific aims described in more detail in the Chairman's grant and summarized briefly as :1)to use mathematical functions (the Gompers function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test hypotheses based on previously identified risk factors (age, ethnicity, parental myopia); 2) to test 4 hypotheses related to environmental risk factors for myopia progression and stabilization and axial elongation in this well-characterized cohort of mopes; and 3) to test three hypotheses related to risk factors for the development of myopia-related changes in IOP, CCT and macular thickness in COSMICC subjects. The high prevalence of myopia (25% of the US adult population) and its prominence as a public health Problem (risk factor for conditions that can cause vision loss and blindness) emphasize the importance of gaining increased understanding of mechanisms underlying progression and eventual stabilization, so that in the future myopia might be limited to low levels. Better understanding of the factors predictive of myopia progression and stabilization also will help guide selection and timing of interventions as well as target those groups that may benefit the most from treatment.

描述（由申请人提供）：该提案是让休斯顿临床中心每年继续检查休斯敦中心的116名目前招募的COSMICC参与者（自97-98招募以来，只有2名受试者）在COSMICC2协议之后再进行5年（总随访，14年）。 The data collected from this center will be used to address specific aims described in more detail in the Chairman's grant and summarized briefly as :1)to use mathematical functions (the Gompers function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test hypotheses based on previously identified risk factors (age, ethnicity, parental myopia); 2）测试4个与环境风险因素有关的假设，用于在这种良好的摩托车队中，近视进展，稳定和轴向伸长； 3）测试与COSMICC受试者IOP，CCT和黄斑厚度与近视相关的变化发展的三个假设。近视的高度患病率（占美国成年人口的25％）及其作为公共卫生的突出率 问题（可能导致视力丧失和失明的疾病的风险因素）强调对进展和最终稳定的机制的了解的重要性，因此将来近视可能仅限于低水平。更好地了解近视进展和稳定的因素也将有助于指导干预措施的选择和时机，并针对那些可能受益于治疗最大的群体。