Curvature Changing Accommodating IOL

改变曲率调节人工晶状体

基本信息

批准号：
8303217
负责人：
James T Schwiegerling
金额：
$ 18.49万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2014-01-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Presbyopia is an age-related disorder in which the crystalline lens becomes less flexible, leading to an inability to focus on near objects. External appliances such as bifocal and progressive addition spectacle lenses have routinely been used to overcome the lack of accommodation. More sophisticated technologies such as multifocal contact lenses and intraocular lenses (IOLs) have been successfully employed to treat presbyopia. However, these technologies trade contrast in the final image for multiple planes of focus. This downside is especially apparent in low lighting conditions. To overcome these limitations, accommodating IOLs have been aggressively pursued in recent years, but the performance of existing technologies has been marginal at best. The first generation of accommodating IOLs operates by translating the optic within the eye. The translation provides an effective power change to the total power of the eye, but the magnitude of translation is enormous compared to the force and movement provided by the ciliary muscle. Consequently, these translation-based technologies have demonstrated little or no benefit to the presbyope. The next generation of accommodating IOLs uses a curvature change in one or more of the lens surfaces to produce a change in power. Substantial power changes can be achieved with only small changes in curvature, and as a result this next generation of lenses is likely to lead to better treatment of presbyopia. This proposal examines the development and ex vivo testing of a novel curvature changing accommodating IOL to determine its potential to treat presbyopia. The goal is to demonstrate the feasibility of a lens that can restore accommodation to pseudophakic individuals.

描述（由申请人提供）：老花眼是一种与年龄相关的疾病，其中晶状体变得不太灵活，导致无法聚焦于近距离物体。通常使用诸如双焦点和渐进多焦点眼镜镜片之类的外部器具来克服调节的不足。多焦点隐形眼镜和人工晶状体（IOL）等更先进的技术已成功用于治疗老花眼。然而，这些技术会牺牲最终图像的对比度来换取多个焦点平面。这个缺点在低光照条件下尤其明显。为了克服这些限制，近年来人们积极追求可调节人工晶状体，但现有技术的性能充其量也只是微不足道的。第一代可调节人工晶状体通过在眼睛内平移光学器件来操作。该平移为眼睛的总功率提供了有效的功率变化，但是与睫状肌提供的力和运动相比，平移的幅度是巨大的。因此，这些基于翻译的技术对老花眼几乎没有好处或没有好处。下一代可调节人工晶状体利用一个或多个晶状体表面的曲率变化来产生屈光力的变化。只需很小的曲率变化就可以实现显着的屈光度变化，因此下一代镜片可能会更好地治疗老花眼。该提案研究了新型曲率变化可调节人工晶状体的开发和离体测试，以确定其治疗老花眼的潜力。目的是证明晶状体可以恢复人工晶状体患者的调节能力。