2011 Gradient Sensing and Directed Cell Migration Gordon Research Conference

2011 梯度传感和定向细胞迁移戈登研究会议

基本信息

批准号：
8128064
负责人：
TOBIAS MEYER
金额：
$ 1万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-01 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8128064
关键词：
Address Allergic Disease Animal Model Area Arthritis Asthma Basic Science Biological Models Biomedical Engineering Cardiovascular Diseases Cell Polarity Cells Chemotaxis Collaborations Complex Cytoskeleton Development Dictyostelium Discipline Disease Environment Goals Growth Cones Health Human Immigration Immune Immunologic Deficiency Syndromes Inflammation Inflammatory Intention Leukocyte Trafficking Link Malignant Neoplasms Modeling Neoplasm Metastasis Nerve Degeneration Neurons Pathogenesis Pathway interactions Public Health Research Research Personnel Rheumatism Scholarship Scientist Signal Transduction Switzerland System Underrepresented Minority Woman Wound Healing abstracting axonal guidance cell motility human disease improved meetings neuron development novel novel strategies novel therapeutics polarized cell posters programs symposium therapeutic development trafficking

项目摘要

DESCRIPTION (provided by applicant): The 2011 Gordon Research Conference (GRC) on Gradient Sensing and Directed Cell Migration will be held from June 5-10, 2011 at Les Diablerets Conference Center in Les Diablerets, Switzerland. This conference will follow three successful Gordon Conferences in the field of chemotaxis research, which have been held every two years since 2005. The conference addresses the basic research question of how cells polarize and migrate directionally in diverse systems by discussing development, neuronal path finding, leukocyte trafficking, wound healing, tissue repair, and cancer. The conference is also relevant to the development of therapeutics aimed at disorders where cell migration is central to disease pathogenesis including: cardiovascular diseases, rheumatic and allergic diseases, asthma, and cancer. The program highlights the commonality of mechanisms that regulate directed cell migration in the context of diverse systems and the implications of these common pathways to the development of disease. The conference will emphasize new concepts about the basic mechanisms that regulate gradient sensing and directed cell migration, and will explore links between cell migration during development, wound healing, immune cell trafficking, and cancer. Nine discussion sessions are planned: (1) Directed Cell Migration in Cancer, (2) Neuronal Polarity and Growth Cone Guidance (3) Directed Cell Migration in Animal Model Systems, (4) Collective Migration in Development and Wound Healing, (5) Inflammation and Leukocyte Trafficking, (6) Cell Signaling in Chemotaxis, (7) Cell Polarity and the Cytoskeleton in Directed Cell Migration, (8) Quantitative Modeling of Directed Cell Migration. The combination of speakers and topics has been selected with the specific intention of stimulating new ideas and collaborations in the field of chemotaxis research. The session speakers, selected from a variety of fields, will emphasize novel, unpublished results directly related to gradient sensing and directed cell migration. Young investigators will be encouraged to present and discuss their findings in a supportive environment through the invitation of up to 20 additional speakers, selected from submitted abstracts, and by participation in the posters sessions. Scholarships will be offered to encourage the attendance of young scientists, women and underrepresented minorities. Throughout the conference, interactions between senior and young investigators will be promoted in both formal and informal settings. Support of this program will assure that the meeting will be successful and will provide much needed sponsorship for outstanding young scientists who wish to attend. PUBLIC HEALTH RELEVANCE: The Gordon Research Conference on Gradient Sensing and Directed Cell Migration addresses the fundamental mechanisms that regulate directed cell migration and axonal path finding. This area of research has substantial importance to the development of new therapeutics to treat a diverse array of human diseases including cancer, cardiovascular disease, arthritis, asthma and neuronal degeneration. This conference will bring together experts who study directed cell migration mechanisms in simple and complex systems in order to stimulate new ideas and advance our abilities to improve public health.

描述（由申请人提供）： 2011 年梯度传感和定向细胞迁移戈登研究会议 (GRC) 将于 2011 年 6 月 5 日至 10 日在瑞士莱迪亚布勒雷会议中心举行。本次会议将继 2005 年以来每两年举办一次的趋化性研究领域的三届戈登会议之后举行。本次会议通过讨论发育、神经元路径寻找、细胞如何在不同系统中极化和定向迁移等基础研究问题，白细胞运输、伤口愈合、组织修复和癌症。此次会议还涉及针对细胞迁移对于疾病发病机制至关重要的疾病的治疗方法的开发，包括：心血管疾病、风湿病和过敏性疾病、哮喘和癌症。该计划强调了在不同系统背景下调节定向细胞迁移的机制的共性以及这些共同途径对疾病发展的影响。会议将强调有关调节梯度传感和定向细胞迁移的基本机制的新概念，并将探讨发育过程中的细胞迁移、伤口愈合、免疫细胞运输和癌症之间的联系。计划举行九场讨论会议：(1) 癌症中的定向细胞迁移，(2) 神经元极性和生长锥指导 (3) 动物模型系统中的定向细胞迁移，(4) 发育和伤口愈合中的集体迁移，(5) 炎症和白细胞贩运，(6) 趋化性中的细胞信号传导，(7) 定向细胞迁移中的细胞极性和细胞骨架，(8) 定量建模定向细胞迁移。选择演讲者和主题的组合的具体目的是激发趋化性研究领域的新想法和合作。来自各个领域的会议发言人将强调与梯度传感和定向细胞迁移直接相关的新颖的、未发表的结果。通过邀请从提交的摘要中选出的最多 20 名额外演讲者以及参加海报会议，鼓励年轻研究人员在支持性环境中展示和讨论他们的发现。将提供奖学金以鼓励年轻科学家、女性和代表性不足的少数族裔参加。在整个会议期间，将在正式和非正式场合促进高级研究人员和年轻研究人员之间的互动。该计划的支持将确保会议取得成功，并将为希望参加的杰出年轻科学家提供急需的赞助。公共健康相关性：戈登梯度传感和定向细胞迁移研究会议讨论了调节定向细胞迁移和轴突路径寻找的基本机制。该研究领域对于开发治疗多种人类疾病（包括癌症、心血管疾病、关节炎、哮喘和神经元变性）的新疗法具有重要意义。本次会议将汇集研究简单和复杂系统中定向细胞迁移机制的专家，以激发新想法并提高我们改善公共卫生的能力。