Behavioral Pharmacology of Drug Dependence

药物依赖性的行为药理学

基本信息

批准号：
8531895
负责人：
CHARLES P FRANCE
金额：
$ 12.64万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-03-01 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8531895
关键词：
Absence of pain sensation Acute Advocacy Affect Affinity Agonist Antidepressive Agents Area Behavior Behavioral Behavioral Research Body Weight decreased Brain Cannabinoids Canned Foods Chronic Clinical Collaborations Data Dependence Development Diet Dopamine Dopamine Agonists Dopamine Receptor Dose Drug Addiction Drug Combinations Drug abuse Drug usage Eating Effectiveness Faculty Fatty acid glycerol esters Fluoxetine Food Funding Future Gender Goals Grant Growth Heroin Human Impulsivity Infrastructure Activities Juice K-Series Research Career Programs Laboratories Measures Mediating Mentors Mentorship Monkeys Morphine Neurotransmitter Receptor Opiate Addiction Opioid Pain Patients Pharmaceutical Preparations Positioning Attribute Preparation Procedures Rattus Receptor Signaling Recruitment Activity Reporting Research Research Activity Research Personnel Research Project Grants Research Training Rewards Risk Safety Selective Serotonin Reuptake Inhibitor Senior Scientist Award Serotonin Site Students Supervision System Testing Therapeutic Effect Time Training Activity Training Programs Translational Research United States National Institutes of Health Withdrawal Work addiction age related animal facility behavioral pharmacology cannabinoid receptor career development discounting dopamine system dopamine transporter drug discrimination drug of abuse feeding food restriction improved indexing inhibitor/antagonist meetings member neurochemistry non-opioid analgesic nutrition opioid withdrawal pre-clinical research pre-doctoral programs receptor reinforcer research study response reuptake scientific organization

项目摘要

This competing continuation of K05DA17918 is submitted in response to PA-09-076 and requests 5 additional years of support to provide protected time for the PI to continue a successful preclinical research program on the behavioral pharmacology of opioids and other drugs and to mentor students and other young investigators in the area of drug abuse. Progress on the original aims of this grant was as follows: 1) increased NIH support for the PI, his mentees, and collaborators; 2) made significant progress in research projects on the behavioral pharmacology of opioids and other drugs of abuse; 3) significantly increased drug abuse research and training activities at UTHSCSA; 4) led the effort to expand and renovate animal facilities for behavioral research on drug abuse; and 5) contributed to the successful career development of student and junior faculty mentees. The current grant comprises 5 specific aims. Aim 1 continues a 23-year research program on opioid dependence and withdrawal with a new focus on drug combinations. Aim 2 builds on compelling new data showing that chronic opioid treatment and its discontinuation dramatically alter delay discounting, an often used measure of an important aspect of impulsivity, delay discounting. Aim 3 continues and expands a successful collaboration with several investigators and explores the effects of food restriction and of eating high fat food on behavioral, neurochemical, and other effects of drugs acting on serotonin and dopamine systems. Aim 4 continues an active mentoring program (>25% effort) of students and young investigators, and Aim 5 promotes further growth in drug abuse research and training activities at UTHSCSA, including preparation of T32 and multi-investigator research applications. Prior support under the K mechanism has allowed the PI to continue and expand his research efforts as well as the research programs of his collaborators. Continued support under this K award will allow the PI to devote at least 75% of his effort to research and mentoring in drug abuse.

K05DA17918的这种竞争延续是根据PA-09-076提交的，请求5 额外的多年支持，为PI提供受保护的时间继续成功的临床前关于阿片类药物和其他药物行为药理学的研究计划，并指导学生以及滥用药物的其他年轻调查人员。这笔赠款的最初目的的进展是如下所示：1）增加对PI，他的受训者和合作者的NIH支持； 2）很重要阿片类药物和其他滥用药物的行为药理学研究项目的进展； 3）在UTHSCSA上大大增加了药物滥用研究和培训活动； 4）带领努力扩展和翻新动物设施，以进行药物滥用行为研究； 5）为学生和初级教师导师的成功职业发展。当前的赠款包括5 具体目标。 AIM 1继续一项有关阿片类药物依赖性的23年研究计划，并与对药物组合的新关注。 AIM 2以引人注目的新数据为基础，表明慢性阿片类药物治疗及其中断会大大改变延迟折现，这是一种经常使用的措施冲动性的重要方面，延迟打折。 AIM 3继续并扩大成功与几位调查人员合作，探讨食物限制和吃高脂的影响作用于5-羟色胺和多巴胺的药物的行为，神经化学和其他作用的食物系统。 AIM 4继续对学生和年轻人进行积极的指导计划（> 25％）调查人员和目标5促进了药物滥用研究和培训活动的进一步增长 UTHSCSA，包括制备T32和多注射研究应用程序。先前的支持 K机制使PI能够继续并扩大他的研究工作以及研究他的合作者计划。根据该K奖的持续支持将使PI至少投入他为滥用药物研究和指导的努力中有75％。