POLARITY IN NETWORKS AND PATHWAYS

网络和途径的极性

• 批准号: 8169565
• 负责人: LESLIE M LOEW
• 金额: $ 8.16万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169565
• 关键词: Automobile Driving; Behavior; Biological; Cell physiology; Cells; Cellular biology; Complex; Computer Retrieval of Information on Scientific Projects Database; Development; Diffusion; Drug Formulations; Funding; Grant; Institution; Life; Location; Measurement; Measures; Methods; Microscope; Modeling; Molecular; Pathway interactions; Property; Research; Research Personnel; Resources; Series; Source; Technology; United States National Institutes of Health; base; computerized tools; in vivo; spatiotemporal; technology development; tool development; virtual

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polarity in networks and pathways is determined by the spatial organization, subcellular distribution, dynamic behavior, interactions and functions of specific molecules within the cell. Understanding the basis for polarity in networks and pathways will require development of new methods to measure concentrations, diffusion properties and interactions of molecules in cells, new ways to manipulate concentrations, locations and interactions of molecules in cells, and new strategies to model interactions of molecules in networks and pathways in different subcellular compartments. The Technology Center for Polarity in Networks and Pathways at the Center for Cell Analysis and Modeling (CCAM) integrates new microscope technologies for making quantitative in vivo live cell measurements with new physical formulations and computational tools that produce spatially realistic quantitative models of intracellular dynamics. Three core technology projects, Model, Measure and Manipulate, provide an integrated framework for elucidating spatiotemporal dynamics in living cells. Development of tools by the Technology Development Cores is motivated by a series of Driving Biological Projects (DBP) that cover major complex problems in cell biology. These DBPs all revolve around the issue of how the cell controls the locations of its molecular components and how that polarity is used to optimize a cellular function. Advances in modeling approaches formulated under this project are subsequently integrated into the Virtual Cell for dissemination to our user base.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 网络和通路的极性由细胞内特定分子的空间组织、亚细胞分布、动态行为、相互作用和功能决定。 了解网络和通路极性的基础将需要开发测量细胞中分子浓度、扩散特性和相互作用的新方法，操纵细胞中分子浓度、位置和相互作用的新方法，以及模拟分子相互作用的新策略在不同亚细胞区室的网络和通路中。细胞分析和建模中心 (CCAM) 的网络和通路极性技术中心集成了用于定量体内活细胞测量的新显微镜技术与新的物理公式和计算工具，可生成细胞内动力学的空间真实定量模型。模型、测量和操纵这三个核心技术项目为阐明活细胞的时空动态提供了一个综合框架。技术开发核心开发工具的动力来自于一系列涵盖细胞生物学中主要复杂问题的驱动生物项目 (DBP)。这些 DBP 都围绕着细胞如何控制其分子成分的位置以及如何利用这种极性来优化细胞功能的问题。 该项目下制定的建模方法的进步随后被集成到虚拟单元中，以便传播给我们的用户群。