Epidemiologic Determinant of Cardiac Structure and Function Among Hispanics

西班牙裔人心脏结构和功能的流行病学决定因素

• 批准号: 8442854
• 负责人: Carlos Jose Rodriguez
• 金额: $ 70.2万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8442854
• 关键词: Acculturation; Adult; Affect; African; Age-Years; Aging; Ancillary Study; Area; Biological Markers; Cardiac; Cardiovascular system; Chicago; Clinical; Data; Data Set; Diabetes Mellitus; Dominican; EFRAC; Echocardiography; Economics; Enrollment; Epidemiologic Factors; Equilibrium; Ethnic group; Funding; Future; Glycosylated Hemoglobin; Goals; Growth; Guidelines; Health; Health Planning; Healthcare; Heart failure; Heterogeneity; High Prevalence; Hispanics; Hypertension; Image; Image Analysis; Individual; Investigation; Latino; Lead; Learning; Left Ventricular Hypertrophy; Life; Literature; Mental Depression; Metabolic syndrome; Methodology; Mexican; Morbidity - disease rate; Names; Not Hispanic or Latino; Obesity; Participant; Population; Prevalence; Prevention; Psychosocial Factor; Public Health; Puerto Rican; Race; Relative (related person); Reporting; Research; Risk; Sample Size; Site; Site Visit; Socioeconomic Factors; South American; Stress; Structure; Subgroup; Techniques; Time; Tissues; United States; United States National Institutes of Health; cardiovascular risk factor; clinical Diagnosis; cohort; community health study; cost; cost effective; design; diabetic; experience; fasting glucose; high risk; innovation; interest; mortality; population based; primary outcome; psychosocial; secondary outcome; social; socioeconomics; stress management

DESCRIPTION (provided by applicant): Given the proportion of the United States (US) population (>16%) composed of Hispanics and the anticipation for continued growth and aging of this ethnic group, Hispanics will comprise a significant consumer of US health care. Hispanics carry more diabetes, metabolic syndrome, hypertension, and West African ancestry in certain subgroups as well as lower socioeconomic conditions than non-Hispanic whites all of which likely affect cardiac function. Pertinent literature is scarce with prior studies being limited by small sample size, inadequate representation of Hispanic heterogeneity, and outdated or less than comprehensive methodology. There are no population-based estimates of the prevalence of abnormal systolic and diastolic cardiac function for Hispanic adults. Our preliminary data suggest that there is more abnormal cardiac structure among Hispanics compared to non-Hispanic whites. We would therefore expect a high prevalence of abnormal cardiac function among Hispanic adults, but this has been understudied. The Hispanic Community Health Study - Study of Latinos (HCHS-SOL), an NIH-funded cohort of 16,000 Hispanic adults, represents a unique, and cost-effective, opportunity to implement a study to fill the gaps described. Specifically, we propose to establish a unique cohort, named ECHO-SOL (Echocardiographic Study of Latinos/Hispanics). Using a separate site visit to obtain an echocardiographic examination of a subsample of 1,800 Hispanic adults from HCHS-SOL to determine a population-based estimate of the prevalence of abnormal systolic and diastolic cardiac function in Hispanic adults, the degree of heterogeneity between Hispanic subgroups in cardiac function, and to establish the relationship of determinants particularly relevant to the Hispanic population (diabetes biomarkers and psychosocial / socioeconomic factors) to cardiac structure and function. The proposed study will provide for the first time the largest and most comprehensive dataset of echocardiographic parameters focused solely on US Hispanics and will be the first to untangle the relative importance of the heterogeneity between Hispanic subgroups and psychosocial / socioeconomic factors on cardiac structure and function among Hispanic adults. ECHO-SOL will be extremely promising in learning about Hispanic cardiovascular health and highly relevant to future public health planning.

描述（由申请人提供）：鉴于由西班牙裔人组成的美国（美国）人口（> 16％）的比例，以及对这个族裔群体持续增长和衰老的期望，西班牙裔将构成美国医疗保健的重要消费者。与非西班牙裔白人相比，西班牙裔携带更多的糖尿病，代谢综合征，高血压和西非血统以及社会经济状况较低的所有这些可能影响心脏功能。相关文献稀缺，先前的研究受到样本量较小，西班牙裔异质性的代表不足的限制，并且过时或不到全面方法。西班牙裔成年人没有基于人群的收缩期和舒张性心脏功能流行的估计。我们的初步数据表明，与非西班牙裔白人相比，西班牙裔的心脏结构异常。因此，我们预计西班牙裔成年人心脏功能异常的流行率很高，但这已经被研究了。 NIH资助的16,000名西班牙裔成年人组成的西班牙裔社区健康研究 - 拉丁裔研究（HCHS-SOL）是一个独特且具有成本效益的机会，可以实施一项研究以填补所描述的空白。具体而言，我们建议建立一个独特的队列，名为Echo-Sol（Latinos/西班牙裔的超声心动图研究）。使用单独的现场访问来获得来自HCHS-SOL的1,800名西班牙裔成年人的子样本的超声心动图检查，以确定基于人群的估计值估计西班牙裔成年人中的收缩期和舒张性心脏功能的普遍性的估计值生物标志物和心理 /社会经济因素）到心脏结构和功能。 拟议的研究将首次提供超声心动图参数的最大，最全面的数据集，仅关注我们的西班牙裔美国人，这将是第一个揭示西班牙裔亚组与心理 /社会经济经济因素对心脏结构和他的女性成年人功能之间异质性相对重要性的相对重要性。 Echo-SOL在学习西班牙裔心血管健康方面将非常有希望，并且与未来的公共卫生计划高度相关。