IGF::OT::IGF LASER-DRIVEN PROTON AND CARBON THERAPY

IGF::OT::IGF 激光驱动质子和碳疗法

• 批准号: 8742678
• 负责人: FINN O'SHEA
• 金额: $ 29.99万
• 依托单位: RADIABEAM TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-20 至 2014-06-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8742678
• 关键词: Acceleration; Address; Cancer Patient; Carbon; Carbon ion; Clinics and Hospitals; Ions; Lasers; Malignant Neoplasms; Optics; Patients; Performance; Phase; Protons; Quality of life; Radiation Oncology; Radiation therapy; Survival Rate; System; Technology; Texas; Treatment Efficacy; Universities; austin; clinical application; conditioning; cost; design; improved; innovation; novel; proton beam; proton therapy; technology development

While the superior therapeutic efficacy of hadron therapy has been clearly demonstrated, its availability to cancer patients is limited by the cost and size of current systems. The proposed project seeks to address this problem by utilizing innovative laser-driven ion acceleration technology for the development of a compact, inexpensive proton therapy system that can ultimately be adapted for the acceleration of carbon ions. High-intensity, 200-300 MeV laser-driven proton beams will be demonstrated with the Texas Petawatt Laser through the implementation of several novel acceleration mechanisms with ultrathin CH2 targets. RadiaBeam Technologies, the University of Texas at Austin , and the UCLA Department of Radiation Oncology will collaborate on the conceptual design of a treatment system for delivering proton therapy, and eventually carbon therapy, with performance sufficient for clinical application at a fraction of the cost and fitting in a single room. This major reduction in size and cost of hadron therapy will make the proposed system a much more realistic option for hospitals and clinics worldwide, thus expanding the pool of patients to which this treatment is available and potentially improving cancer survival rates as well as the quality of life for radiotherapy patients.

尽管已经清楚地证明了强子疗法的优质治疗功效，但其可用性 癌症患者受到当前系统的成本和大小的限制。拟议的项目旨在解决 通过利用创新激光驱动的离子加速技术来开发一个问题 紧凑，廉价的质子治疗系统，最终可以适应碳的加速 离子。高强度，200-300 MEV激光驱动的质子梁将通过德克萨斯州Petawatt展示 通过实施具有超薄CH2靶标的几种新型加速机制的激光。 Radiabeam Technologies，德克萨斯大学奥斯汀分校和UCLA辐射系 肿瘤学将在治疗系统的概念设计上合作，以提供质子治疗，并 最终碳疗法，其性能足以以临床应用的成本占临床应用，并且 安装在单人间。强大疗法的大小和成本的重大降低将使拟议 系统对于全球医院和诊所来说是更现实的选择，从而扩大了患者的库 该治疗可用，并有可能提高癌症生存率以及 放射治疗患者的寿命。