Teen Alcohol Screening in the Pediatric Emergency Care Applied Research Network

儿科紧急护理应用研究网络中的青少年酒精筛查

基本信息

批准号：
8539739
负责人：
JAMES G LINAKIS
金额：
$ 62.53万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-05 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8539739
关键词：
17 year old Accident and Emergency department Adolescence Adolescent Adult Affect Age Alcohol abuse Alcohol consumption Alcohol dependence Alcohol or Other Drugs use Alcoholism Alcohols Anatomy Applied Research Behavior Behavioral Caring Childhood Cigarette Cognitive Data Diagnosis Drug usage Early Diagnosis Early identification Emergency Care Enrollment Ethnic Origin Frequencies Future Gender Goals Gold Health Institutes Insurance Intervention Marijuana Smoking Measurement Measures Medical Morbidity - disease rate Multicenter Trials Neuropsychology Participant Patients Performance Persons Physicians Population Primary Health Care Problem behavior Public Health ROC Curve Race Recommendation Research Research Infrastructure Risk Risk Behaviors Sample Size Sampling Sampling Studies School-Age Population Sensitivity and Specificity Site Student Dropouts Surveys Teenagers Testing Visit Youth alcohol and other drug alcohol misuse alcohol screening alcohol use disorder base brief advice brief intervention brief screening design drinking follow-up high risk high school instrument middle school mortality motivational intervention neurochemistry novel response screening sex tool underage drinking validation studies

项目摘要

DESCRIPTION (provided by applicant): Alcohol use is a major contributor to the leading causes of adolescent morbidity and mortality and to other health risks, including other substance use and risky behaviors. Adolescent alcohol use may also result in long term cognitive, behavioral, anatomic and neurochemical changes. Additionally, initiating alcohol use in adolescence significantly increases a person's risk for adult alcohol use disorders. Given this considerable public health burden, successfully identifying adolescents at risk for current or future problematic alcohol use is of major importance, as intervention may significantly affect both adolescent and adult alcohol use disorders. The National Institute of Alcohol Abuse and Alcoholism (NIAAA) has developed a novel two-question screening tool for the early detection of alcohol use and problems. Empirically based, the screen may be a powerful predictor of current and future negative consequences of alcohol use. We propose to test the goals of RFA- AA-12-008 by validating the NIAAA two-question screen with 12-17 year olds in 15 U.S. pediatric emergency departments (PED), by pursuing two specific aims: Primary Aim 1) To determine the concurrent, convergent, discriminant, and predictive validity of the two-question screen regarding alcohol misuse, and Secondary Aim 1) To determine the concurrent and predictive validity of the two-question screen regarding other substance use and risky behaviors. The advantage of the PED setting is the ability to capture high risk populations such as school dropouts and those without primary care or insurance, who often use PEDs for their medical care and are missed in other study settings. Employing the Pediatric Emergency Care Applied Research Network (PECARN), we will use a multi-center design to test the concurrent, convergent and predictive validity of the NIAAA two-question screen using established, validated measurement instruments in a very large, diverse sample of youths. Youths 12-17 years (N=8000) presenting to participating PECARN PEDs will be enrolled over a 3.5-year period and will complete the two-question screen and an alcohol and other drug (AOD) and behavior ("criterion") assessment battery. Responses from these youths will be used to assess the concurrent convergent, and discriminant validity of the NIAAA two-question screen. Two subsamples of youths will be derived from the initial sample. The first subsample (N=300) will be re-administered the NIAAA two-question screen, one week after their initial ED visit to assess the test-retest reliability of the NIAAA two-question screen. The second sample (N=2500), will be reassessed at 12 and 24 months after their PED visit with the criterion assessment battery to assess the predictive validity of the two-question screen. This large sample will permit stratified analyses by gender, race, ethnicity and other important demographic variables, which are not possible with single center or smaller sample studies. The proposed research is significant because it rigorously evaluates the ability of the NIAAA two-question screen to predict current and future AOD risks as well as other behavior problems, and will generate very robust, generalizable results.

描述（由申请人提供）：饮酒是青少年发病率和死亡率以及其他健康风险（包括其他药物使用和风险行为）的主要原因的主要因素。青少年饮酒也可能导致长期的认知，行为，解剖和神经化学变化。此外，在青春期启动饮酒会显着增加一个人患成人饮酒障碍的风险。鉴于这种巨大的公共卫生负担，成功地识别出有问题或将来有问题的饮酒风险的青少年至关重要，因为干预可能会严重影响青少年和成人酒精使用障碍。美国国家酒精滥用与酒精中毒研究所（NIAAA）开发了一种新型的两问题筛查工具，用于早期发现酒精的使用和问题。基于经验，屏幕可能是对酒精使用的当前和未来负面后果的有力预测指标。我们建议通过追求两个具体目的：主要目的1：主要目标1），通过验证NIAAA两次提出的屏幕（PED），以确定一致，融合，歧视性和预测性的两次概述，确定酒精的效果，第二个针对性的有效性，以确定酒精的两种特定目的，以确定酒精的两种特定目的，以确定酒精的两种特定目的，以确定酒精的两种特定目的，以确定酒精的两种特定目的，以确定酒精的两种特定目的，以确定rfa-aa-12-008的目标，并在美国15个美国儿科急诊室（PED）中进行12-17岁的孩子（PED），并确定其第二个目标。有关其他物质使用和风险行为的两问题屏幕。 PED设置的优点是能够捕获高风险人群，例如学校辍学和没有初级保健或保险的人，他们经常将PED用于医疗服务，并且在其他学习环境中被错过。采用小儿急诊应用研究网络（PECARN），我们将使用多中心设计来测试NIAAA两问题屏幕的同时，收敛性和预测性的有效性，并使用已建立的，经过验证的测量工具中的大型，多样的年轻人样本中。参加参与佩卡恩PED的12-17岁（n = 8000）将在3。5年内招募，并将完成两疑问屏幕，酒精和其他药物（AOD）和行为（“标准”）评估电池。这些年轻人的反应将用于评估NIAAA两问题屏幕的并发收敛性和判别有效性。两个年轻人的子样本将从最初的样本中得出。第一个子样本（n = 300）将在初次访问后一周重新管理NIAAA两次问题屏幕，以评估NIAAA两次问题的重测可靠性。第二个样本（n = 2500）将在访问标准评估电池的PED访问后的12和24个月重新评估，以评估两个问题屏幕的预测有效性。这个大样本将允许通过性别，种族，种族和其他重要人口统计学变量进行分层分析，而单个中心或较小的样本研究不可能。拟议的研究之所以重要，是因为它严格评估了NIAAA两问题预测当前和未来AOD风险以及其他行为问题的能力，并将产生非常强大的，可推广的结果。