Modifiable lifestyle-related factors and triple negative breast cancer prognosis

可改变的生活方式相关因素与三阴性乳腺癌预后

• 批准号: 8512931
• 负责人: Sarah Jean Nechuta
• 金额: $ 7.8万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8512931
• 关键词: Accounting; Affect; African; Alcohol consumption; Biologic Characteristic; Biological; Biology; Body Weight Changes; Body mass index; Breast; Breast Cancer Risk Factor; Cancer Prognosis; Cancer Survivor; Characteristics; China; Clinical; Cohort Studies; Conflict (Psychology); Consumption; Data; Diagnosis; Diagnostic; Dietary Factors; Eating; Epidermal Growth Factor Receptor; Estrogen Receptors; Frequencies; Future; Goals; Green tea; Guidelines; Histopathologic Grade; Hormone Receptor; Hormones; Human; Intake; Lead; Life Style; Literature; Measures; Meta-Analysis; Morbidity - disease rate; Mutation; Myoepithelial; Nurses' Health Study; Obesity; Outcome; Overweight; P-Cadherin; Pathology; Physical activity; Population; Progesterone Receptors; Prospective Studies; Public Health; Recommendation; Recruitment Activity; Recurrence; Reporting; Reproductive History; Research; Resources; Risk; Role; Soy Foods; Survival Rate; TP53 gene; Tea; Tumor Biology; United Kingdom; United States; Vegetables; Vimentin; Waist-Hip Ratio; Woman; aged; cancer recurrence; cohort; cost effective; design; diet and exercise; experience; improved; lifestyle factors; malignant breast neoplasm; mortality; outcome forecast; prospective; public health relevance; response; therapeutic target; triple-negative invasive breast carcinoma; tumor

DESCRIPTION (provided by applicant): Triple negative breast cancers (TNBCs) are defined as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) negative. TNBCs, accounting for about 11-20% of invasive breast cancers, are more aggressive, have a poorer prognosis, and have few targeted treatment options, compared with hormone-sensitive breast cancers. A growing body of literature suggests post- diagnosis, lifestyle-related factors may impact overall breast cancer prognosis. However, little is known about the role of modifiable lifestyle-related factors in TNBC prognosis. To date, no prospective cohort study has investigated lifestyle-related factors that have been implicated in breast cancer prognosis overall, specifically in the prognosis of TNBC. This effort has not been feasible in the past due primarily to the need for data on post- diagnosis lifestyle factors and breast cancer outcomes in a large population of women with TNBC. The proposed study will overcome these limitations by using the resources of the After Breast Cancer Pooling Project (ABCPP), a collaborative project that includes four prospective cohorts of breast cancer survivors, for which we have successfully pooled and harmonized data on clinical characteristics and lifestyle factors. With the addition of two more ongoing cohort studies, we anticipate a total of approximately 1,550 women diagnosed with invasive TNBC recruited from the United States, the United Kingdom, and Shanghai, China. Our overall hypothesis is that the associations of lifestyle-related factors with breast cancer recurrence and mortality may differ for women with TNBC, as compared to women with ER+ breast cancer, depending on the underlying biological mechanisms for each lifestyle factor-breast cancer outcome association. To investigate this hypothesis, we propose to evaluate the associations of post-diagnosis body mass index, weight change, post-diagnosis recreational physical activity, and select dietary factors suggested to be associated with breast cancer prognosis overall (i.e., soy food intake, vegetable intake, alcohol consumption, and tea consumption) with recurrence, breast cancer-specific mortality, and total mortality among women (1) with TNBC and (2) with ER+ breast cancer. The proposed collaborative study, which will pool the resources of six prospective cohorts of breast cancer survivors, will be the first study that is sufficiently powered to investigate the effect of modifible lifestyle-related factors on TNBC prognosis. The findings of our study will lead to public health recommendations and guidelines appropriate for breast cancer survivors with TNBC, information critically needed, with the ultimate goal of reducing morbidity and mortality among breast cancer survivors. This study, building upon an existing collaborative pooling project and experienced research team, is cost-effective. Further, the proposed project will help sustain collaborative research efforts to promote future pooled analyses in the ABCPP.

描述（由申请人提供）：三阴性乳腺癌（TNBC）被定义为雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体2（HER2）阴性。 TNBC 约占浸润性乳腺癌的 11-20%，与激素敏感型乳腺癌相比，TNBC 更具侵袭性，预后较差，并且缺乏针对性的治疗选择。越来越多的文献表明，诊断后，生活方式相关因素可能会影响乳腺癌的整体预后。然而，很少的是 了解可改变的生活方式相关因素在 TNBC 预后中的作用。迄今为止，还没有前瞻性队列研究调查与乳腺癌整体预后有关的生活方式相关因素，特别是 TNBC 的预后。这项工作在过去并不可行，主要是因为需要大量 TNBC 女性诊断后生活方式因素和乳腺癌结果的数据。拟议的研究将通过利用乳腺癌后汇集项目 (ABCPP) 的资源来克服这些限制，该项目是一个合作项目，其中包括四个乳腺癌幸存者的前瞻性队列，我们​​已成功汇集和协调了有关临床特征和生活方式因素的数据。 。加上另外两项正在进行的队列研究，我们预计将从美国、英国和中国上海招募大约 1,550 名被诊断患有侵袭性 TNBC 的女性。我们的总体假设是，与 ER+ 乳腺癌女性相比，TNBC 女性的生活方式相关因素与乳腺癌复发和死亡率的关联可能有所不同，具体取决于每种生活方式因素与乳腺癌结果关联的潜在生物学机制。为了研究这一假设，我们建议评估诊断后体重指数、体重变化、诊断后娱乐性身体活动的关联，并选择与乳腺癌总体预后相关的饮食因素（即大豆食物摄入量、蔬菜摄入量）。女性 (1) TNBC 和 (2) ER+ 乳腺癌女性的复发、乳腺癌特异性死亡率和总死亡率。拟议的合作研究将汇集六个乳腺癌幸存者前瞻性队列的资源，这将是第一项有足够能力调查可改变的生活方式相关因素对 TNBC 预后影响的研究。我们的研究结果将产生适合 TNBC 乳腺癌幸存者的公共卫生建议和指南，这是迫切需要的信息，最终目标是降低乳腺癌幸存者的发病率和死亡率。这项研究建立在现有的协作池项目和经验丰富的研究团队的基础上，具有成本效益。此外，拟议的项目将有助于维持合作研究工作，以促进 ABCPP 未来的汇总分析。