LGD Core

LGD核心

• 批准号: 8763775
• 负责人: Janelle Cortner
• 金额: $ 186.55万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8763775
• 关键词: Aliquot; Bioinformatics; Carcinoma; Cell Line; Cohort Studies; DNA; Data; Disease; Genetic; Genotype; HIV; Population; Sampling; Source; cohort; human disease; Aliquot; Bioinformatics; Carcinoma; Cell Line; Cohort Studies; DNA; Data; Disease; Genetic; Genotype; HIV; Population; Sampling; Source; cohort; human disease

The genetics core is focused on human disease population cohort studies and is organized into three functional units: biospecimen curation, genotyping/sequencing, and bioinformatics. Disease cohorts include numerous HIV-infected cohorts, nasopharengeal carcinoma, and hepC, among others. Biospecimen curation unit recieves samples, makes cell lines and DNAs. Cell lines serve as a renewable source of DNA. DNAs are aliquoted onto multiwell plates for sequencing or genotyping by that unit of the core, or for sending to collaborators. Sequence & genotype data is analyzed by the bioinformatics unit.

遗传学核心集中在人类疾病人群研究上，并组织为三个功能单位：生物测量策展，基因分型/测序和生物信息学。疾病队列包括许多HIV感染的队列，鼻charengeal癌和HEPC等。生物测量策展单元回收样品，制作细胞系和DNA。细胞系充当可再生的DNA来源。 DNA被等分放在多层板上，以通过核心单元或发送给合作者进行测序或基因分型。序列和基因型数据由生物信息学单元分析。