MMC and VICC: Partnership for Survivorship (1 of 2)

MMC 和 VICC：幸存者合作伙伴关系（2 中的 1）

• 批准号: 8540359
• 负责人: John J. Murray
• 金额: $ 19.4万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-23 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8540359
• 关键词: Address; Adult; Advisory Committees; African American; Area; Basic Science; Behavior; Cancer Center; Cancer Center Planning Grant; Cancer Center Support Grant; Cancer Control; Cancer Survivor; Cancer Survivorship; Caucasians; Caucasoid Race; Clinical Research; Cohort Studies; Collaborations; Color; Communities; Data; Development; Disadvantaged; Educational workshop; Environmental Exposure; Epidemiology; Equilibrium; Ethnic group; Exposure to; Extramural Activities; Faculty; Funding; Goals; Grant; Health; Incidence; Inferior; Institution; Intervention; Intervention Studies; Joints; Lead; Life; Life Style; Long Term Survivorship; Malignant Neoplasms; Methodology; Minority; Minority-Serving Institution; Morbidity - disease rate; Outcome; Physiological; Pilot Projects; Population; Population Sciences; Premature Mortality; Prevalence; Prevention; Preventive Intervention; Recording of previous events; Research; Research Infrastructure; Research Personnel; Resources; Risk Factors; Series; Severities; Survivors; Tennessee; Underserved Population; United States; United States National Institutes of Health; Universities; adverse outcome; anticancer research; cancer health disparity; cancer therapy; clinical care; cohort; design; experience; health disparity; innovation; medical schools; meetings; mortality; prevent; programs; psychosocial; racial and ethnic; socioeconomics; survivorship

The Meharry Medical College (MMC) and the Vanderbilt-lngram Cancer Center (VICC) propose to develop a new and innovative program centered on Cancer Survivorship Research and Cancer Survivorship Health Disparities. This is designed to be a sustainable and mutually beneficial program that significantly enhances the current Meharry-Vanderbilt Cancer Partnership (MVCP) funded U54, and efficiently utilizes already established resources. There are now over 11 million people in the United States living with a history of cancer with African Americans experiencing higher rates of mortality than do other racial/ethnic groups for reasons that are only partly understood. For cancer survivors, effects of the cancer treatment, lifestyle behaviors and environmental exposures can also lead to long-term morbidity and premature mortality. Yet, surprisingly little research has been conducted in "survivorship" to assess long term outcomes especially among adult cancer survivors, and in particular, minority survivor populations where baseline health disparities exist. Therefore, descriptive and analytic epidemiologic cohort studies are required to estimate the incidence of adverse physiologic and psychosocial long-term outcomes and evaluate their determinants to inform the development of best practices for preventive interventions. This proposal is designed to plan, prioritize and implement a series of collaborative pilot projects, using mixed methodologies with the following specific objectives: 1) To establish Cancer Survivorship research initiatives as a priority for the MVCP and integrate this area of research and clinical care into the existing partnership infrastructure; 2) To stimulate interactions and collaborations among faculty at MMC, VICC and a collaborating minority institution, Tennessee State University; 3) To stimulate research into the determinants of health disparities in cancer survivorship, including the biologic, socioeconomic, demographic and health-related risk factors associated with inferior survival of underserved populations (including populations of color, socio-economically challenged); and 4) To identify the incidence, prevalence, spectrum, and severity of adverse long-term health-related outcomes following cancer treatment and develop interventions to prevent or ameliorate such outcomes. The benefits of such an expanded partnership and program of research include for both MMC and VICC: 1) faculty development and recruitment with increased exposure to this line of research for trainees and junior faculty; 2) increases in pilot projects and ultimately competitive extramural funding that will now include research along the entire cancer control continuum; 3) expansion of the MVCP funded U54 and VICC support grant to include cancer survivorship research; 4) expansion of cancer health disparities research to include study of disparities in the quality and quantity of long-term survivorship; 5) facilitation of increased minority participation in cancer survivorship disparities research, with respect to both investigators and subjects.

Meharry医学院（MMC）和Vanderbilt-Lngram癌症中心（VICC）提议开发一个以癌症生存研究和癌症生存健康差异为中心的新的创新计划。这被设计为一个可持续且互惠互利的计划，可显着增强当前资助U54的Meharry-Vanderbilt癌症合作伙伴关系（MVCP），并有效利用已经建立的资源。现在，美国有超过1100万人患有癌症史，非洲裔美国人的死亡率比其他种族/族裔群体更高，原因只有部分被理解。对于癌症幸存者，癌症治疗，生活方式行为和环境暴露的影响也会导致长期发病率和早亡率。然而，令人惊讶的是，在“幸存者”中几乎没有进行研究以评估长期结局，尤其是在成年癌症幸存者中，尤其是存在基线健康差异的少数族裔幸存者。因此，需要描述性和分析性流行病学队列研究来估计不良生理和社会心理的长期结局的发生率，并评估其决定因素，以告知开发预防性干预措施的最佳实践。该提案旨在计划，优先级和实施一系列协作试点项目，使用与以下特定目标的混合方法：1）建立癌症生存研究计划，作为MVCP的优先事项，并将研究和临床护理的这一领域整合到现有的合作伙伴关系基础设施中； 2）刺激MMC的VICC教师之间的互动和合作，以及田纳西州立大学合作的少数民族机构； 3）刺激对癌症生存中健康差异的决定因素的研究，包括生物学，社会经济，人口统计学和与健康相关的危险因素，与服务不足的人群的生存率较低（包括颜色，社会经济挑战）； 4）确定癌症治疗后与长期健康相关的不良健康结果的发生率，流行率，频谱和严重程度，并制定了预防或改善此类结果的干预措施。这种扩展的合作伙伴关系和研究计划的好处包括MMC和VICC：1）教师的发展和招聘，增加了对学员和初级教师的研究趋势的增加； 2）试点项目的增加和最终的竞争性校外资金，现在将包括整个癌症控制连续性的研究； 3）扩大了MVCP资助的U54和VICC支持补助金，以包括癌症生存研究； 4）扩大癌症健康差异研究的扩大，包括研究长期生存质量和数量的差异； 5）就研究人员和受试者而言，促进少数群体参与癌症生存差异研究。