Fellowship Training Program in Vaccinology

疫苗学奖学金培训计划

• 批准号: 8550999
• 负责人: Myron Max Levine
• 金额: $ 21.73万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550999
• 关键词: Fellowship; Training Programs; vaccinology

DESCRIPTION (provided by applicant): Vaccination is one of the most cost-effective approaches in preventive medicine. Over the past 3 decades, new techniques in recombinant DNA and biotechnology have offered unprecedented opportunities for developing new vaccines. Many training opportunities exist to prepare individuals for research in immunology, molecular genetics, infectious diseases, and other specific aspects of vaccine development, but few training programs offer broad exposure to both laboratory and clinical trial aspects of vaccinology as a cohesive discipline. For the past 37 years, the Center for Vaccine Development of the University of Maryland School of Medicine has been involved in all aspects of vaccine development, from basic laboratory studies involving genetic construction of recombinant vaccines to Phase 1 through Phase 4 clinical trials. We propose to continue a formal training program in which individuals with M.D. or Ph.D. (or equivalent) degrees can be prepared specifically for careers in vaccinology, either to pursue basic vaccine development research or to conduct investigative clinical trials and translational research. Two new trainees will join the training program in each of the five years and training for each trainee will ensue fr 3 (sometimes 4) years. Support only for years 1 and 2 is requested in this proposal; support for the 3rd and possible 4th years will come from fellowships, research grants, or other sources. The Training Program in Vaccinology offers to all trainees a broad exposure to both the laboratory and clinical trial phases of vaccinology. Beyond this broad exposure, the program has two tracks to provide each trainee with intensive experience in either the laboratory aspects or the clinical phases of vaccinology, depending upon which track they choose. The Laboratory Track allows the training of basic scientists and physician-scientists in vaccine development laboratory research, particularly in the use of recombinant DNA technology to prepare new vaccine candidates and the use of modern immunological techniques to study the human humoral and cellular immune response to vaccines. The Clinical Track trains clinicians (internists or pediatricians) in trial design, protocol development, regulatory and ethical clearances, performance of clinical trials, data analysis and clinical translational research. The ultimate goal of this training program is to provide a well-trained cadre of individuals who can fully exploit the unprecedented opportunities now available in vaccine development.

描述（由申请人提供）：疫苗接种是预防医学中最具成本效益的方法之一。在过去的30年中，重组DNA和生物技术方面的新技术为开发新疫苗提供了前所未有的机会。存在许多培训机会，可以使个人为免疫学，分子遗传学，传染病和疫苗开发的其他特定方面的研究做好准备，但是很少有培训计划可为疫苗学作为粘性学科的实验室和临床试验方面提供广泛的影响。在过去的37年中，马里兰大学医学院的疫苗开发中心一直参与疫苗开发的各个方面，从涉及重组疫苗的基因结构到第1阶段到第4阶段临床试验的基础实验室研究。我们建议继续一项正式培训计划，其中拥有医学博士学位或博士学位的个人。 （或同等）可以专门为疫苗学职业准备，以从事基本疫苗开发研究或进行调查性临床试验和转化研究。两名新学员将在五年中的每一年中加入培训计划，每位受训者的培训将发生3（有时为4）年。仅在本提案中要求提供1年和2年的支持；对第三年和可能的第四年的支持将来自研究金，研究补助金或其他来源。疫苗学方面的培训计划为所有学员提供了对疫苗学的实验室和临床试验阶段的广泛接触。除了这一广泛的曝光外，该计划还有两条轨道，可为每个学员提供在实验室方面或疫苗学的临床阶段的丰富经验，具体取决于他们选择的轨道。该实验室的轨道允许在疫苗开发实验室研究中培训基本科学家和医师科学家，特别是在使用重组DNA技术来准备新的疫苗候选物以及使用现代免疫技术来研究人类的体液和细胞对疫苗的影响。临床轨道培训临床医生（内科医生或儿科医生），用于试验设计，协议开发，监管和道德清除，临床试验的性能，数据分析和临床转化研究。该培训计划的最终目标是提供训练有素的人群，这些人能够充分利用疫苗开发中目前可用的前所未有的机会。