Basal ganglia and dopamine contributions to feedback-based learning

基底神经节和多巴胺对基于反馈的学习的贡献

• 批准号: 8115017
• 负责人: Karin Foerde
• 金额: $ 5.46万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8115017
• 关键词: Acute; Affect; Alzheimer' s Disease; Animals; Automobile Driving; Basal Ganglia; Behavioral; Biological Models; Brain Chemistry; Characteristics; Chronic; Cognition; Cognitive; Computer Simulation; Corpus striatum structure; Data; Disease; Dopamine; Elderly; Episodic memory; Feedback; Functional disorder; Future; Health; Hippocampus (Brain); Human; Individual; Lead; Learning; Link; Medial; Memory; Mental Depression; Modeling; Nature; Neuropsychology; Parkinson Disease; Participant; Patients; Pharmaceutical Preparations; Population; Prefrontal Cortex; Reaction Time; Research; Rewards; Role; Schizophrenia; Signal Transduction; Specificity; Support System; System; Temporal Lobe; Testing; Time; base; flexibility; healthy aging; information organization; insight; neuropsychological; relating to nervous system; response; young adult

DESCRIPTION (provided by applicant): The broad aim of this proposal is to understand the cognitive and neural systems that support incremental, feedback-based learning. Recent evidence suggests that this type of learning depends on the basal ganglia (BG) - primarily the striatum and its dopaminergic afferents. By contrast, a distinct and independent memory system in the medial temporal lobe (MTL) is thought to support rapidly formed memories of single-trial episodes. However, recent studies have shown that this dichotomy may be oversimplified, and that in many cases the BG and the MTL both contribute to learning. Thus, fundamental questions remain regarding the circumstances under which each of these systems support learning and the implications of their involvement for the representation of knowledge. Bridging across electrophysiological data, computational modeling, and human neuropsychology, the proposed research aims to test the hypothesis that a critical factor driving learning to depend on one system or the other is the timing of response-contingent feedback. The studies herein seek to test this hypothesis by systematically investigating how the timing of feedback (immediate vs. delayed) modulates different aspects of learning and memory. Our model system is healthy older adults and individuals with Parkinson's disease, who suffer from disrupted BG function but have intact MTL function. We will further examine both chronic and acute dopamine perturbations by examining how dopaminergic medication modulates feedback-based learning in Parkinson's patients. Finally, we aim to determine the cognitive mechanisms involved under different delay conditions, comparing incremental and episodic learning. The resulting findings are expected to enhance our understanding of the cognitive and neural systems supporting feedback-based learning, and how these are modulated by BG dysfunction and dopaminergic mechanisms. PUBLIC HEALTH RELEVANCE: Parkinson's disease is characterized by a range of learning deficits. The resulting findings will provide insight into the nature, and possible cause, of these deficits, as well as how they are impacted by medication. Understanding the basic mechanisms of feedback-based learning is also relevant to other diseases that affect large segments of the population, such as Alzheimer's disease, depression, and schizophrenia - all characterized by learning and memory problems. By understanding how people learn in different ways as a result of changes in feedback information and how brain chemistry affects this learning, we can better understand how to help those already suffering from such diseases and contribute to better treatments in the future.

描述（由申请人提供）：该提案的主要目标是了解支持增量、基于反馈的学习的认知和神经系统。最近的证据表明，这种类型的学习取决于基底神经节（BG）——主要是纹状体及其多巴胺能传入神经。相比之下，内侧颞叶（MTL）中独特且独立的记忆系统被认为支持快速形成单次试验事件的记忆。然而，最近的研究表明，这种二分法可能过于简单化，并且在许多情况下 BG 和 MTL 都有助于学习。因此，关于这些系统中的每一个支持学习的环境以及它们的参与对知识表示的影响仍然存在基本问题。这项研究跨越了电生理学数据、计算模型和人类神经心理学，旨在检验这样一种假设：驱动学习依赖于一个系统或另一个系统的关键因素是反应相关反馈的时间。本文的研究试图通过系统地研究反馈的时间（立即与延迟）如何调节学习和记忆的不同方面来检验这一假设。我们的模型系统是健康的老年人和患有帕金森病的个体，他们的 BG 功能受到破坏，但 MTL 功能完好。我们将通过研究多巴胺能药物如何调节帕金森病患者基于反馈的学习来进一步研究慢性和急性多巴胺扰动。最后，我们的目标是通过比较增量学习和情景学习来确定不同延迟条件下涉及的认知机制。由此产生的结果预计将增强我们对支持基于反馈的学习的认知和神经系统的理解，以及这些系统如何通过 BG 功能障碍和多巴胺能机制进行调节。公共卫生相关性：帕金森病的特点是一系列学习缺陷。由此产生的结果将深入了解这些缺陷的性质和可能的原因，以及它们如何受到药物的影响。了解基于反馈的学习的基本机制也与影响大部分人群的其他疾病有关，例如阿尔茨海默病、抑郁症和精神分裂症，所有这些疾病的特点都是学习和记忆问题。通过了解人们如何因反馈信息的变化而以不同的方式学习，以及大脑化学物质如何影响这种学习，我们可以更好地了解如何帮助那些已经患有此类疾病的人，并为未来更好的治疗做出贡献。

项目成果

Dopamine Modulation of Intertemporal Decision-making: Evidence from Parkinson Disease.

跨期决策的多巴胺调节：帕金森病的证据。

• 发表时间: 2016-05
• 影响因子: 3.2
• 作者: Foerde, Karin;Figner, Bernd;Doll, Bradley B;Woyke, Isabel C;Braun, Erin Kendall;Weber, Elke U;Shohamy, Daphna
• 通讯作者: Shohamy, Daphna

Motivational modes and learning in Parkinson's disease.

帕金森病的动机模式和学习。

• 发表时间: 2015-08
• 作者: Foerde, Karin;Braun, Erin Kendall;Higgins, E Tory;Shohamy, Daphna
• 通讯作者: Shohamy, Daphna

The role of the basal ganglia in learning and memory: insight from Parkinson's disease.

基底神经节在学习和记忆中的作用：帕金森病的见解。

• 发表时间: 2011-11
• 影响因子: 2.7
• 作者: Foerde, Karin;Shohamy, Daphna
• 通讯作者: Shohamy, Daphna