TARGETED TRANSCRANIAL ELECTROTHERAPY SYSTEM TO ACCELERATE STROKE RECOVERY

靶向经颅电疗系统加速中风恢复

基本信息

  • 批准号:
    8199404
  • 负责人:
  • 金额:
    $ 31.98万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-08-01 至 2013-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Transcranial Direct Current Stimulation (tDCS) with weak currents is a non-invasive, low-cost, and well tolerated technique producing lasting functional changes in the central nervous system. There is increasing evidence supporting the use of tDCS to improve stroke rehabilitation. Behavioral and therapeutic outcomes of tDCS depend on the brain areas being targeted. However, conventional approaches are limited in that they insufficiently activate the target region and/or result in unspecific stimulation throughout the entire head. To address this, High-Definition tDCS (HD-tDCS) using arrays of specifically designed electrodes has been proposed. The high-definition approach results in more focal and targeted stimulation as compared to conventional electrode montages. It allows for exceptional flexibility in designing targeted and individualized electrotherapy. When focusing on peri-lesional areas the multi-electrode high-definition approach is predicted to achieve not only more focal stimulation but importantly, also increased intensity in the peri-lesional areas with the same total currents applied to the electrodes. Thus, the high-definition approach holds promise to achieving not only safer but also stronger activation of rehabilitation targets and thus more effective rehabilitation outcomes. This project will design, prototype, and validate the first electrotherapy system optimized for stroke rehabilitation, "Rehabilitation HD-tDCS" (rHD-tDCS); moreover this system is the first to apply advanced software algorithms and existing HD-tDCS technology to leverage the presence of the lesion to guide current to precise targets in an individually optimized fashion. The main goal of this project is the focal and reliable stimulation of peri-lesional cortical targets to improve stroke rehabilitation. The efficacy of the technique will be demonstrated on improved language training in stroke patients with aphasia. Milestones for a successful Phase-1 are: 1. Automated modeling and optimization of current flows in accurate anatomical models of stroke lesions and surrounding areas. 2. Prototype of a programmable stimulation device and electrode montage optimized for targeting these stroke areas. 3. Successful rehabilitation treatment of aphasia with the rHD-tDCS device. The stimulation device and protocols developed in this project are further applicable to motor rehabilitation in stroke and other promising areas of targeted electro-therapy. PUBLIC HEALTH RELEVANCE: Electrical stimulation with small currents trough the scalp produce significant improvements in rehabilitation training, in particular the recovery of language skills after a stroke. This projects aims to developed advanced technology called Rehabilitation High-Definition transcranial Direct Current Stimulation (rHD-tDCS) which can guide therapeutic electrical currents trough multiple electrodes to brain regions involved in functional recovery while sparing the rest of the brain. This is expected to improve safety, reliability, and efficacy of stroke rehabilitation training.
描述(由申请人提供): 弱电流经颅直流电刺激 (tDCS) 是一种非侵入性、低成本且耐受性良好的技术,可在中枢神经系统中产生持久的功能变化。越来越多的证据支持使用 tDCS 来改善中风康复。经颅直流电刺激 (tDCS) 的行为和治疗结果取决于所针对的大脑区域。然而,传统方法的局限性在于它们不足以激活目标区域和/或导致整个头部的非特异性刺激。为了解决这个问题,人们提出了使用专门设计的电极阵列的高清 tDCS (HD-tDCS)。与传统的电极蒙太奇相比,高清方法可产生更集中和更有针对性的刺激。它在设计有针对性的个性化电疗方面具有非凡的灵活性。当聚焦于病灶周围区域时,预计多电极高清方法不仅可以实现更多的焦点刺激,而且重要的是,在施加到电极的总电流相同的情况下,还可以增加病灶周围区域的强度。因此,高清方法有望实现不仅更安全,而且更有力地激活康复目标,从而获得更有效的康复结果。该项目将设计、原型设计并验证第一个针对中风康复优化的电疗系统“康复 HD-tDCS”(rHD-tDCS);此外,该系统首次应用先进的软件算法和现有的 HD-tDCS 技术,利用病变的存在,以单独优化的方式将电流引导至精确目标。该项目的主要目标是对病灶周围皮质目标进行集中且可靠的刺激,以改善中风康复。该技术的功效将通过改善中风失语症患者的语言训练来证明。第一阶段成功的里程碑是: 1. 在中风病变及周围区域的精确解剖模型中自动建模和优化电流。 2. 针对这些中风区域进行优化的可编程刺激装置和电极蒙太奇原型。 3.使用rHD-tDCS装置成功康复治疗失语症。该项目开发的刺激装置和协议进一步适用于中风的运动康复和其他有前景的靶向电疗领域。 公共卫生相关性: 通过头皮进行小电流电刺激可显着改善康复训练,特别是中风后语言技能的恢复。该项目旨在开发称为康复高清经颅直流电刺激(rHD-tDCS)的先进技术,该技术可以通过多个电极将治疗电流引导至涉及功能恢复的大脑区域,同时不影响大脑的其余部分。这有望提高中风康复训练的安全性、可靠性和有效性。

项目成果

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LUCAS C PARRA其他文献

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{{ truncateString('LUCAS C PARRA', 18)}}的其他基金

Machine learning for risk-adjusted breast MRI screening
用于风险调整乳房 MRI 筛查的机器学习
  • 批准号:
    10316235
  • 财政年份:
    2020
  • 资助金额:
    $ 31.98万
  • 项目类别:
Machine learning for risk-adjusted breast MRI screening
用于风险调整乳房 MRI 筛查的机器学习
  • 批准号:
    10521264
  • 财政年份:
    2020
  • 资助金额:
    $ 31.98万
  • 项目类别:
Effects of direct-current stimulation on synaptic plasticity
直流电刺激对突触可塑性的影响
  • 批准号:
    9913593
  • 财政年份:
    2016
  • 资助金额:
    $ 31.98万
  • 项目类别:
TARGETED TRANSCRANIAL ELECTROTHERAPY SYSTEM TO ACCELERATE STROKE RECOVERY
靶向经颅电疗系统加速中风恢复
  • 批准号:
    8307445
  • 财政年份:
    2011
  • 资助金额:
    $ 31.98万
  • 项目类别:
CRCNS: Effects of Weak Applied Currents on Memory Consolidation During Sleep
CRCNS:弱施加电流对睡眠期间记忆巩固的影响
  • 批准号:
    8286826
  • 财政年份:
    2010
  • 资助金额:
    $ 31.98万
  • 项目类别:
CRCNS: Effects of Weak Applied Currents on Memory Consolidation During Sleep
CRCNS:弱施加电流对睡眠期间记忆巩固的影响
  • 批准号:
    8286826
  • 财政年份:
    2010
  • 资助金额:
    $ 31.98万
  • 项目类别:
CRCNS: Effects of Weak Applied Currents on Memory Consolidation During Sleep
CRCNS:弱施加电流对睡眠期间记忆巩固的影响
  • 批准号:
    8055164
  • 财政年份:
    2010
  • 资助金额:
    $ 31.98万
  • 项目类别:
CRCNS: Effects of Weak Applied Currents on Memory Consolidation During Sleep
CRCNS:弱施加电流对睡眠期间记忆巩固的影响
  • 批准号:
    8150936
  • 财政年份:
    2010
  • 资助金额:
    $ 31.98万
  • 项目类别:
CRCNS: Effects of Weak Applied Currents on Memory Consolidation During Sleep
CRCNS:弱施加电流对睡眠期间记忆巩固的影响
  • 批准号:
    8517819
  • 财政年份:
    2010
  • 资助金额:
    $ 31.98万
  • 项目类别:

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