Proteomics, Bioanalysis and Bioinformatics - E (Subaward)

蛋白质组学、生物分析和生物信息学 - E（Subaward）

• 批准号: 8473252
• 负责人: Jun Qu
• 金额: $ 6.25万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8473252
• 关键词: Bioinformatics; Biological Markers; Biological Sciences; Buffaloes; Childhood; Clinical; Clinical Pharmacology; Clinical Research; Collaborations; Computer Simulation; Core Facility; Data; Data Quality; Data Set; Development; Equipment; Evaluation; Goals; Individual; Laboratories; Medical; Medical center; Medicine; Methodology; Methods; Molecular; New York; Optics; Pharmaceutical Preparations; Pharmacologic Substance; Procedures; Proteins; Proteomics; Research; Research Personnel; Resources; Retinopathy of Prematurity; Sampling; Scientist; Specimen; Tissues; Translational Research; Universities; Work; data mining; high throughput analysis; in vivo; instrumentation; liquid chromatography mass spectrometry; neonate; novel; novel therapeutics; pre-clinical; programs; small molecule

The Proteomics, Bioanalysis and Bioinformatics Core is located in downtown Buffalo within the New York State Center of Excellence in Bioinformatics & Life Sciences (CEBLS) (http://www.bioinformatics.buffalo.edu/). which is a free-standing facility integral to the University at Buffalo/SUNY and the Buffalo-Niagara Medical Center. Key functional capabilities of this Module are: a) small molecule analysis (drugs, metabolites and endogenous compounds); b) proteomic analysis of tissues from both normal and pathological specimens; and c) bioinformatics applications for creation, management and correlative analysis of large data sets, such as those derived from proteomics analyses, as well as other in silico applications. The kinds of instrumentation and range of capabilities included in this Core facility are state-of-the-art (the State of New York and other entities have invested more than $15 million into the facility and its instrumentation so far), and are not readily available at the other SUNY campuses. Accessibility to this Core will be afforded to support the ongoing and newly emerging research programs covered in this proposal, which requires the kinds of methodologies and analytical capabilities offered by this core. This core will also facilitate ongoing and new collaborations between investigators who are developing novel therapeutic efforts for Retinopathy of Prematurity.

蛋白质组学，生物分析和生物信息学核心位于纽约州卓越生物信息和生命科学卓越中心（CEBLS）（http://www.bioinformatics.buffalo.edu/）内。这是布法罗/纽约大学和布法罗尼亚加拉医学中心大学的独立设施。该模块的关键功能功能是：a） 小分子分析（药物，代谢产物和内源性化合物）； b）来自正常和病理标本的组织的蛋白质组学分析； c）用于创建，管理和相关性分析的大型数据集的生物信息学应用程序，例如蛋白质组学分析以及在计算机应用中的其他分析。该核心设施中包含的工具和功能范围是最先进的（纽约州和其他实体已经向设施及其仪器投资了超过1500万美元），并且在其他SUNY校园不容易获得。该核心的可访问性将提供支持该提案中涵盖的持续和新兴的研究计划，该计划需要该核心提供的方法和分析能力。该核心还将促进正在为早产性视网膜病变而开发新的治疗努力的调查人员之间的持续和新合作。