EFFICACY OF BITTER TASTE BLOCKERS ON FLAVOR ACCEPTANCE IN PEDIATRIC POPULATIONS

苦味阻滞剂对儿童口味接受的功效

基本信息

批准号：
8402095
负责人：
JULIA ANNE MENNELLA
金额：
$ 30.11万
依托单位：
MONELL CHEMICAL SENSES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-01-01 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8402095
关键词：
8 year old Address Adenosine Monophosphate Adult Affect Age Biological Assay Biology Butyric Acids Caffeine Child Childhood Clinical Medicine Clinical Research Cognitive Complex Data Databases Deglutition Development Dose Drug Formulations Effectiveness Employee Strikes Encapsulated Family Flavoring Future Genes Genetic Variation Genotype Glutamates Health Human Individual Investigation Knowledge Label Lead Life Liquid substance Literature Mediator of activation protein Medicine Methods Modeling Oral Participant Pathway interactions Patients Pharmaceutical Preparations Pharmacologic Substance Play Population Procedures Propylthiouracil Psychophysics Publishing Quinine Receptor Cell Relative (related person)Research Research Project Grants Role Scientific Advances and Accomplishments Sensory Signal Transduction Sodium Sodium gluconate Solid Staging Stimulus Sucrose Tablets Taste Perception Testing Urea Variant denatonium benzoate design dosage experience hedonic innovation insight novel pill preference programs public health priorities public health relevance receptor research study response sensory system

项目摘要

DESCRIPTION (provided by applicant): Taste plays a central role in clinical medicine and is crucial for pediatric patients because the unpleasant taste of drugs thwarts the benefits of even the most powerful drug. For two reasons, pediatric medications are particularly problematic. First, children often cannot or will not swallow pills or tablets (which encapsulates the inherently bitter tasting medications). Second, their enhanced (relative to adults) sensitivity to bitterness leads them to strongly reject bitter liquid medicines. We propose experimental studies applying recent scientific advances in bitter taste biology which have identified compounds that may interfere with bitter perception by taste receptor cells, to determine: (1) the effectiveness of these bitter blockers in children and adults for different model bitter compounds and (2) how age and genetic variation affects the efficacy of the bitter blockers.

描述（由申请人提供）：味道在临床医学中起着核心作用，对于儿科患者至关重要，因为药物的难闻味道会阻碍即使是最强大的药物的益处。由于两个原因，儿科药物尤其成问题。首先，儿童通常不能或不会吞咽药丸或药片（其中封装了固有的苦味药物）。其次，他们（相对于成年人）对苦味的敏感性增强，导致他们强烈拒绝苦味液体药物。我们建议应用苦味生物学的最新科学进展进行实验研究，这些研究已经确定了可能干扰味觉受体细胞苦味感知的化合物，以确定：（1）这些苦味阻滞剂对儿童和成人不同模型苦味化合物的有效性，以及（ 2) 年龄和遗传变异如何影响苦味阻滞剂的功效。