Reduction in spread of excitation as predictor multi-channel spectral resolution

减少激励扩散作为预测器多通道光谱分辨率

• 批准号: 8810293
• 负责人: David M Landsberger
• 金额: $ 40.14万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8810293
• 关键词: Reduction; spread; excitation; predictor; multi

Project Summary / Abstract Cochlear implant (CI) users may be unable to access all of the spectral information provided by their device because of channel interactions between electrodes. Current "focusing" may reduce channel interaction and thereby improve spectral resolution. Depending on patient-related factors (e.g., neuronal health, location of electrodes, etc.), individual CI users may or may not benefit from current focusing. The overall goals of this research are to improve CI users' functional spectral resolution via current focusing and to identify CI users that may benefit from focused stimulation. We hypothesize that if current focusing can reduce the spread of excitation, then channel interaction will be reduced and the spectral resolution will be increased, thereby CI performance in challenging listening conditions (e.g., speech in noise, music perception). If current focusing is applied to "current steered" virtual channels, the spectral resolution may be further increased. Ultimately, current shaping (steering and focusing) can be optimized for individual CI users, allowing for efficient transmission of the maximum amount of spectral cues for each patient. In Specific Aim 1, we will measure the spread of excitation (SOE) for single electrodes at multiple cochlear locations, with and without current focusing. In Specific Aim 2, we will measure perception of simple multi- channel stimuli, with and without current focusing. In Specific Aim 3, we will implement and evaluate experimental signal processing strategies with and without current focusing. Taken together, these experiments will provide important insights regarding the relevance of the SOE for perception of complex multi-channel stimuli, as well as guidance toward optimizing current shaping for individual CI patients in a clinical setting. The proposed research is significant because it aims to: a) improve CI performance in challenging listening conditions, b) develop current-shaping strategies for clinical processors, and c) create quick clinical tests to optimize current shaping for individual patients. The research is innovative in that it seeks to develop and implement new signal processing strategies to improve CI users' spectral resolution. The research approach combines objective measures (ECAPs), subjective descriptors, single- and multi-channel psychophysics, and evaluations of experimental signal processing to better understand who might benefit from current focusing, and under what circumstances.

项目摘要 /摘要 人工耳蜗（CI）用户可能无法访问其设备提供的所有光谱信息 由于电极之间的通道相互作用。当前的“聚焦”可能会降低通道交互作用，并且 从而改善光谱分辨率。取决于患者相关的因素（例如，神经元健康，位置 电极等），单个CI用户可能会或可能不会从当前的注意力中受益。总体目标 研究是通过当前的聚焦来改善CI用户的功能频谱分辨率并识别CI用户 这可能会受益于重点刺激。我们假设，如果当前的聚焦可以减少 激发，然后将减少通道相互作用，并增加光谱分辨率，从而CI 在具有挑战性的聆听条件下的表现（例如，噪音中的语音，音乐感知）。如果当前的聚焦是 应用于“当前转向”虚拟通道，可以进一步增加光谱分辨率。最终， 当前的成型（转向和聚焦）可以针对单个CI用户进行优化，从而有效 每位患者的最大光谱线索传输量。 在特定的目标1中，我们将测量单电极在多个耳蜗上的激发（SOE）的传播（SOE） 位置，有和没有当前的聚焦。在特定的目标2中，我们将衡量对简单多型的感知 通道刺激，有和没有当前聚焦。在特定目标3中，我们将实施和评估 具有和没有当前聚焦的实验信号处理策略。 综上所述，这些实验将提供有关国有企业相关性的重要见解 对复杂多通道刺激的感知，以及优化当前塑形的指导 在临床环境中的个别CI患者。拟议的研究很重要，因为它的目的是：a）改进 CI在具有挑战性的聆听条件下的表现，b）制定临床的当前形成策略 处理器以及c）创建快速的临床测试，以优化单个患者的当前成型。研究是 创新的是，它试图制定和实施新的信号处理策略以改善CI用户的 光谱分辨率。研究方法结合了客观措施（ECAP），主观描述符， 单通道心理物理学以及对实验信号处理的评估以更好 了解谁可能会从当前的关注点以及在什么情况下受益。