Reduction in spread of excitation as predictor multi-channel spectral resolution

减少激励扩散作为预测器多通道光谱分辨率

• 批准号: 8810293
• 负责人: David M Landsberger
• 金额: $ 40.14万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8810293
• 关键词: Reduction; spread; excitation; predictor; multi

Project Summary / Abstract Cochlear implant (CI) users may be unable to access all of the spectral information provided by their device because of channel interactions between electrodes. Current "focusing" may reduce channel interaction and thereby improve spectral resolution. Depending on patient-related factors (e.g., neuronal health, location of electrodes, etc.), individual CI users may or may not benefit from current focusing. The overall goals of this research are to improve CI users' functional spectral resolution via current focusing and to identify CI users that may benefit from focused stimulation. We hypothesize that if current focusing can reduce the spread of excitation, then channel interaction will be reduced and the spectral resolution will be increased, thereby CI performance in challenging listening conditions (e.g., speech in noise, music perception). If current focusing is applied to "current steered" virtual channels, the spectral resolution may be further increased. Ultimately, current shaping (steering and focusing) can be optimized for individual CI users, allowing for efficient transmission of the maximum amount of spectral cues for each patient. In Specific Aim 1, we will measure the spread of excitation (SOE) for single electrodes at multiple cochlear locations, with and without current focusing. In Specific Aim 2, we will measure perception of simple multi- channel stimuli, with and without current focusing. In Specific Aim 3, we will implement and evaluate experimental signal processing strategies with and without current focusing. Taken together, these experiments will provide important insights regarding the relevance of the SOE for perception of complex multi-channel stimuli, as well as guidance toward optimizing current shaping for individual CI patients in a clinical setting. The proposed research is significant because it aims to: a) improve CI performance in challenging listening conditions, b) develop current-shaping strategies for clinical processors, and c) create quick clinical tests to optimize current shaping for individual patients. The research is innovative in that it seeks to develop and implement new signal processing strategies to improve CI users' spectral resolution. The research approach combines objective measures (ECAPs), subjective descriptors, single- and multi-channel psychophysics, and evaluations of experimental signal processing to better understand who might benefit from current focusing, and under what circumstances.

项目概要/摘要 人工耳蜗 (CI) 用户可能无法访问其设备提供的所有光谱信息 由于电极之间的通道相互作用。当前的“聚焦”可能会减少渠道互动， 从而提高光谱分辨率。取决于患者相关因素（例如神经元健康状况、神经元位置） 电极等），个人 CI 用户可能会也可能不会从电流聚焦中受益。本次活动的总体目标 研究目的是通过电流聚焦来提高 CI 用户的功能光谱分辨率并识别 CI 用户 这可能会受益于集中刺激。我们假设，如果当前的聚焦可以减少传播 激发，则通道相互作用将减少，光谱分辨率将增加，从而 CI 在具有挑战性的聆听条件下的性能（例如，噪声中的语音、音乐感知）。如果当前对焦为 应用于“电流引导”虚拟通道，可以进一步提高光谱分辨率。最终， 电流整形（转向和聚焦）可以针对个人 CI 用户进行优化，从而实现高效 为每位患者传输最大量的光谱线索。 在具体目标 1 中，我们将测量多个耳蜗处单个电极的激励传播 (SOE) 位置，有或没有当前对焦。在具体目标 2 中，我们将测量对简单多因素的感知 通道刺激，有或没有电流聚焦。在具体目标 3 中，我们将实施并评估 有和没有电流聚焦的实验信号处理策略。 总而言之，这些实验将为了解国有企业的相关性提供重要见解。 对复杂多通道刺激的感知，以及优化电流整形的指导 临床环境中的个别 CI 患者。拟议的研究意义重大，因为它的目的是：a）改进 在具有挑战性的聆听条件下的 CI 性能，b) 为临床开发电流整形策略 处理器，以及 c) 创建快速临床测试以优化个体患者的当前塑形。该研究是 创新之处在于它寻求开发和实施新的信号处理策略来提高 CI 用户的 光谱分辨率。研究方法结合了客观测量（ECAP）、主观描述、 单通道和多通道心理物理学，以及实验信号处理的评估，以更好地 了解谁可能从当前的关注中受益，以及在什么情况下受益。