Proteomics

蛋白质组学

• 批准号: 8470583
• 负责人: Fred E Regnier
• 金额: $ 3.7万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8470583
• 关键词: Address; Biological; Cancer Center Support Grant; Chemistry; Client; Complex; Computers and Advanced Instrumentation; Data; Drug Delivery Systems; Individual; Investigation; Laws; Liquid substance; Malignant Neoplasms; Mass Spectrum Analysis; Molecular; NCI Center for Cancer Research; Pain; Pharmaceutical Chemistry; Play; Post-Translational Protein Processing; Protein Analysis; Proteins; Proteomics; Proteomics Shared Resource; Publications; Research; Research Personnel; Resource Sharing; Role; Services; Technology; Tissue Extracts; Training; Work; base; experience; high throughput analysis; instrumentation; mass spectrometry shared resource; member; novel strategies; professor; programs

The Center for Cancer Research's Proteomics Shared Resource is a new Shared Resource that combines various proteomic services (global proteomic, protein identification, and single protein analysis) in a single facility to better serve the needs of the Center for Cancer Research members. The Proteomics Shared Resource is distinguished from the Mass Spectrometry Shared Resource, which focuses on the analysis of small organic compounds to primarily support chemistry-driven projects in the Medicinal Chemistry and Drug Delivery and Molecular Sensing scientific programs. The advanced instrumentation in the Proteomic Shared Resource supports: 1) the high throughput analysis of biological fluids and tissue extracts; 2) the identification of proteins in cellular complexes; and 3) the analysis of protein modifications. The Shared Resource is directed by Dr. Fred Regnier, the J. H. Law Distinguished Professor of Chemistry who has over 30 years experience as a leader in the field of applied mass spectrometry technology. Dr. Regnier is ideally suited to direct this new Shared Resource and to guide and facilitate new avenues of investigation by Center for Cancer Research members who may not be familiar with the capabilities the instrumentation the new facility offers.

癌症研究中心的蛋白质组学共享资源是一种新的共享资源，结合了 单个蛋白质组学服务（全球蛋白质组学，蛋白质鉴定和单一蛋白质分析） 更好地满足癌症研究中心需求的设施。蛋白质组学共享 资源与质谱共享资源区分开来，该资源的重点是分析 小型有机化合物主要支持药物化学和药物中的化学驱动项目 交付和分子传感科学程序。蛋白质组学中的高级仪器共享 资源支持：1）生物流体和组织提取物的高吞吐量分析； 2） 细胞复合物中蛋白质的鉴定； 3）蛋白质修饰的分析。共享 资源由J. H. Law杰出化学教授Fred Regnier博士指导 在应用质谱技术领域的领导者中，有30年的经验。 Regnier博士是理想情况下 适合指导这种新的共享资源，并指导和促进中心的新调查途径 对于可能不熟悉功能的癌症研究成员，新的仪器 设施提供。