Fast, Robust Analysis of Large Population Data

对大量人口数据进行快速、稳健的分析

• 批准号: 7780861
• 负责人: Dinggang Shen
• 金额: $ 33.3万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7780861
• 关键词: Aging; Algorithms; Alzheimer' s Disease; Atlases; Brain; Brain Diseases; Brain imaging; Clinical Research; Communities; Complex; Computers; Data; Data Set; Detection; Development; Disease; Drug Formulations; Early Diagnosis; Goals; Growth; Image; Individual; Informatics; Intervention; Learning; Location; Longitudinal Studies; Magnetic Resonance Imaging; Matched Group; Measurement; Memory; Methods; Monitor; Monozygotic twins; Neonatal; Nerve Degeneration; Noise; Patients; Performance; Population; Process; Research; Resources; Series; Speed; Staging; Statistical Distributions; Techniques; Testing; Time; Twin Multiple Birth; Uncertainty; base; cerebral atrophy; comparison group; evaluation/testing; image registration; interest; neuroimaging; neuropsychiatry; novel; relating to nervous system; research study; tool

DESCRIPTION (provided by applicant): Modern imaging, such as MRI, can provide a safe, non-invasive measurement of the whole brain, and has been increasingly employed for large clinical and research studies of brain development, maturation, and aging, as well as for monitoring the effects of pharmacological interventions over time. This has created a great need for the development of highly automated, accurate, and robust measurement tools for analysis of large neuroimage dataset. Image registration as an important image measurement tool has attracted enormous scientific interest, since it is the key step for integration and comparison of data from different individuals or groups, as well as for the development of statistical atlases that reflect structural and functional variability within a group of individuals. However, most of the current registration algorithms are based on pair-wise registration of an individual brain with a selected template. This independent pair-wise registration and the subjective selection of template can introduce systematic registration error and bias to the aligned images, thus reducing the statistical power in detecting subtle brain changes, e.g., tiny longitudinal structural and functional changes which are important for early detection of Alzheimer's Disease (AD). To resolve these limitations, group-wise registration and inter-group comparison methods have been recently proposed to achieve consistent registration across all subjects by simultaneous registration of all individual subjects to their group mean directly. However, the accuracy and robustness of these group-wise registration methods are limited in identifying tiny brain differences, since the independent estimation of potentially large complex deformations from each subject to the group mean directly can make the initially very similar images (with tiny difference) become very different after registration, due to noise and uncertainty in the registration. Moreover, because of the required simultaneous registration of a large set of images and the limitation of computer memory capability, current group-wise registration methods can handle only a small number of images, e.g., several to dozens. The first aim of this project is to develop a fast, robust, and accurate group-wise registration algorithm which is able to handle simultaneously a large set of images, e.g., hundreds or thousands of images, by a general computer. Our key idea is to partition a large-scale group-wise registration problem into a series of hierarchical small-scale registration problems, each of which can be handled efficiently by a general computer and can be solved robustly and accurately by simplification of the registration problem. Moreover, for effective comparison of two (or more) groups, i.e., obtained respectively from early-stage diseased patients and normal controls, or from genetically identical twins, we further propose a novel inter- group registration method to effectively align two groups by matching not only their means but also their statistical distributions at all corresponding locations. Thus, the statistical difference between the two groups can be greatly identified, which enables the detection of tiny brain atrophies due to diseases such as those found during the early stage of AD or tiny brain growth differences within twins. This inter-group registration and comparison method can also be extended for the registration of multiple groups, with application in longitudinal study of twins at early neonatal stage. The study of all these novel inter-group registration and comparison methods is the topic of the second aim. Finally, we will apply our developed group-wise registration method, as well as the inter-group registration and comparison method, to the ADNI (Alzheimer's Disease Neuroimaging Initiative) dataset for early detection of AD, and to the neonatal dataset for study of tiny brain growth differences within twins. The performance of the proposed method will be extensively validated and also compared with those obtained by pair-wise registration methods as well as by other group-wise registration methods. These studies are the topic of the third aim. The final developed algorithms will be made freely available to the whole research community through NITRC (Neuroimaging Informatics Tools and Resources Clearinghouse), as we did with our HAMMER registration algorithm (http://www.nitrc.org/projects/hammer/), which is one of the top downloaded tools in NITRC. PUBLIC HEALTH RELEVANCE: This project aims at the development, testing, and evaluation of fast, robust, and accurate group registration and statistical comparison algorithms for effective simultaneous processing of large sets of brain images; to enable the detection of tiny, complex group differences. This is important for early detection of brain diseases (e.g., Alzheimer's Disease) and for identification of tiny brain growth differences within genetically identical twins. The final developed algorithms will be made freely available to the whole research community through NITRC (Neuroimaging Informatics Tools and Resources Clearinghouse), as we did with our HAMMER registration algorithm (http://www.nitrc.org/projects/hammer/), which is currently one of the top download tools in NITRC.

描述（由申请人提供）：现代成像技术，例如 MRI，可以提供对整个大脑的安全、非侵入性测量，并且已越来越多地应用于大脑发育、成熟和衰老的大型临床和研究中。至于随着时间的推移监测药物干预的效果。这就迫切需要开发高度自动化、准确且强大的测量工具来分析大型神经图像数据集。图像配准作为一种重要的图像测量工具引起了巨大的科学兴趣，因为它是整合和比较来自不同个体或群体的数据以及开发反映群体内结构和功能变异性的统计图谱的关键步骤的个人。然而，当前大多数配准算法都是基于个体大脑与选定模板的成对配准。这种独立的成对配准和模板的主观选择可能会给对齐的图像引入系统配准误差和偏差，从而降低检测细微大脑变化的统计能力，例如微小的纵向结构和功能变化，这对于早期检测很重要阿尔茨海默病（AD）。为了解决这些限制，最近提出了分组配准和组间比较方法，通过将所有个体受试者同时直接配准到其组平均值来实现所有受试者的一致配准。然而，这些分组配准方法的准确性和鲁棒性在识别微小的大脑差异方面受到限制，因为直接对每个受试者到组平均值的潜在大的复杂变形进行独立估计可以使最初非常相似的图像（具有微小的差异）由于注册中的噪音和不确定性，注册后变得非常不同。此外，由于需要同时配准大量图像以及计算机内存容量的限制，当前的分组配准方法只能处理少量图像，例如几个到几十个。该项目的首要目标是开发一种快速、稳健且准确的分组配准算法，该算法能够通过通用计算机同时处理大量图像，例如数百或数千个图像。我们的关键思想是将大规模的分组配准问题划分为一系列分层的小规模配准问题，每个问题都可以由通用计算机有效处理，并且可以通过配准问题的简化来稳健而准确地解决。 此外，为了有效比较两个（或更多）组，即分别从早期患病患者和正常对照，或从基因相同的双胞胎中获得的组，我们进一步提出了一种新的组间配准方法，通过匹配来有效地对齐两组不仅是它们的平均值，还有它们在所有相应位置的统计分布。因此，可以极大地识别两组之间的统计差异，从而能够检测由于 AD 早期发现的疾病或双胞胎中微小的大脑生长差异等疾病引起的微小脑萎缩。这种组间登记和比较方法还可以扩展到多组登记，应用于新生儿早期双胞胎的纵向研究。所有这些新颖的组间注册和比较方法的研究是第二个目标的主题。 最后，我们将把我们开发的分组配准方法以及组间配准和比较方法应用到 ADNI（阿尔茨海默病神经影像倡议）数据集以进行 AD 的早期检测，并应用到新生儿数据集以研究微小的双胞胎之间的大脑发育差异。所提出方法的性能将得到广泛验证，并与成对配准方法以及其他成组配准方法获得的性能进行比较。这些研究是第三个目标的主题。 最终开发的算法将通过 NITRC（神经影像信息学工具和资源交换所）免费提供给整个研究社区，就像我们对 HAMMER 注册算法所做的那样 (http://www.nitrc.org/projects/hammer/)，这是 NITRC 中下载次数最多的工具之一。 公共卫生相关性：该项目旨在开发、测试和评估快速、稳健、准确的组配准和统计比较算法，以有效同时处理大量脑图像；能够检测微小、复杂的群体差异。这对于早期发现脑部疾病（例如阿尔茨海默病）以及识别基因相同的双胞胎中微小的大脑生长差异非常重要。最终开发的算法将通过 NITRC（神经影像信息学工具和资源交换所）免费提供给整个研究社区，就像我们对 HAMMER 注册算法所做的那样 (http://www.nitrc.org/projects/hammer/)，目前是 NITRC 中最热门的下载工具之一。