THE FRAMINGHAM SCHOOL STUDY OF NEVI IN CHILDREN SONIC II

弗雷明汉学校对儿童《索尼克 II》中 Nevi 的研究

• 批准号: 8468117
• 负责人: ALLAN C HALPERN
• 金额: $ 66.94万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-26 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8468117
• 关键词: 3-Dimensional; Acute; Adolescence; Adolescent; Affect; Age; Anatomic Sites; Anatomy; Back; Biology; Characteristics; Child; Childhood; Classification; Clinical; Complex; Confocal Microscopy; Data; Development; Diagnosis; Dysplastic Nevus; Early Diagnosis; Education; Epidemiology; Etiology; Evolution; Excision; Face; Funding; Gender; Genetic; Genotype; Goals; Growth; Health; Human; Image; Imaging technology; Individual; Knowledge; Lead; Learning; Leg; Lesion; Longitudinal Studies; Malignant Neoplasms; Measures; Melanocytic Neoplasm; Minority; Mole the mammal; Natural History; Neck; Nevi and Melanomas; Nevus; Nevus Cell; Pathway interactions; Pattern; Peripheral; Phenotype; Photography; Photosensitivity; Pigmentation physiologic function; Predictive Value; Prevalence; Prevention; Public Health; Research Design; Risk; Risk Marker; Sampling; Schools; Site; Skin; Skin Cancer; Stratification; Students; Sun Exposure; Testing; United States; age group; arm; base; cohort; design; early adolescence; eighth grade; eleventh grade; fifth grade; high risk; improved; in vivo; indexing; insight; man; melanocyte; melanoma; mortality; ninth grade; novel; population based; prevent; screening; skin lesion; trait; tumor progression

DESCRIPTION (provided by applicant): Nevi are among the most common skin lesions in man and are critically important risk markers and potential precursors of malignant melanoma. Observations from the initial funding cycle of this project are changing our understanding of the natural history of nevi. We observed that nevus involution is common in childhood. We further observed two subsets of nevi with distinct dermoscopic patterns (globular versus reticular), that these distinct patterns remain stable in childhood, and that they have different size and anatomic distributions on the back. An additional highly novel observation in our study has been the recognition of subtle reticular and globular dermoscopic patterns in normal appearing skin that correlate with the pattern of the overlying nevi, and in the case of the globular skin pattern, correlate with the presence of previously unrecognized sub-clinical aggregates of nevus cells. Lastly, we observed that by the 5th grade a minority of children have developed nevi with a complex dermoscopic pattern. Here, we propose to build on these observations by using a longitudinal study design in an expanded sample from the same population-based cohort to test the following hypotheses: (1) Ongoing sun exposure impacts the evolution and involution of nevi in adolescence, (2) There are two dermoscopically recognizable subsets of nevi that are distinguishable based on their anatomic distribution and their differing associations with pigmentation phenotype, genotype, and presence of subclinical nevus aggregates; and (3) dermoscopically complex nevi in childhood are predictors of a high risk nevus phenotype in late adolescence. We will employ the cutting edge imaging technologies of 3- dimensional total body photography and in vivo reflectance confocal microscopy to accomplish these goals. The insights into nevus classification, etiology, and evolution gained from this study are anticipated to have significant public health, clinical, and scientific benefits. They will lead to better targeting of melanoma prevention in childhood and adolescence through improved risk stratification. These insights will also enhance studies of the biology of melanoma through the distinction of varied nevus associated pathways of melanocytic tumor progression. And, they will permit education of clinicians about the changes that routinely occur in nevi in adolescence which, in turn, should lead to a reduction of the large number of unnecessary nevus excisions in this age group.

描述（由申请人提供）：NEVI是人类中最常见的皮肤病变之一，是恶性黑色素瘤的至关重要的风险标记和潜在的前体。该项目最初资助周期的观察正在改变我们对Nevi自然历史的理解。我们观察到，奈夫的反应在童年时期很常见。我们进一步观察到了两个具有不同皮肤镜模式（球形与网状）的Nevi子集，即这些独特的模式在儿童时期保持稳定，背面具有不同的大小和解剖分布。在我们的研究中，另一个高度新颖的观察结果是对正常皮肤中微妙的网状和球形皮肤镜模式的认识，与上覆的Nevi的模式相关，并且在球状皮肤模式的情况下，与先前未知的存在相关奈夫细胞的亚临床聚集体。最后，我们观察到，到五年级，少数儿童已经发展出具有复杂的皮肤镜模式的Nevi。在这里，我们建议通过在从相同基于人群的同类人群中扩展的样本中使用纵向研究设计来基于这些观察，以检验以下假设：（1）持续的太阳暴露会影响NEVI在青春期的演变和涉及（2）（2）（2（2）（2 ）NEVI有两个可识别的皮肤识别子集，它们可根据其解剖分布以及与色素沉着表型，基因型以及亚临床奈VUS骨料的存在的不同关联而区分。 （3）童年时期的皮肤上复杂的nevi是青春期后期高风险nevus表型的预测指标。我们将采用3维全身摄影和体内反射共聚焦显微镜的尖端成像技术来实现这些目标。预计从这项研究中获得的Nevus分类，病因和进化论的见解预计将具有重要的公共卫生，临床和科学益处。通过改善风险分层，它们将在儿童期和青春期中更好地靶向预防黑色素瘤。这些见解还将通过不同的黑色素肿瘤进展相关途径的区别来增强黑色素瘤生物学的研究。而且，他们将允许对临床医生进行有关青春期常规发生的变化的教育，这反过来又将导致减少该年龄段的大量不必要的Nevus切除。

项目成果

Change in dermoscopic pattern of naevi in children: a commentary.

儿童痣皮肤镜模式的变化：评论。

• DOI: 10.2340/00015555-1630
• 发表时间: 2014
• 期刊: Acta dermato-venereologica
• 影响因子: 3.6
• 作者: Scope,Alon;Marghoob,AshfaqA;Dusza,StephenW;Oliveria,SusanA;Halpern,AllanC
• 通讯作者: Halpern,AllanC

Towards three-dimensional temporal monitoring of naevi: a comparison of methodologies for assessing longitudinal changes in skin surface area around naevi.

• DOI: 10.1111/bjd.14700
• 发表时间: 2016-12
• 期刊: The British journal of dermatology
• 作者: Chung E;Marchetti MA;Scope A;Dusza SW;Fonseca M;DaSilva D;Bajaj S;Geller AC;Bishop M;Marghoob AA;Halpern AC
• 通讯作者: Halpern AC

Sunburn, sun exposure, and sun sensitivity in the Study of Nevi in Children.

儿童痣研究中的晒伤、阳光照射和阳光敏感性。

• DOI: 10.1016/j.annepidem.2015.05.004
• 发表时间: 2015
• 期刊: Annals of epidemiology
• 影响因子: 5.6
• 作者: Satagopan,JayaM;Oliveria,SusanA;Arora,Arshi;Marchetti,MichaelA;Orlow,Irene;Dusza,StephenW;Weinstock,MartinA;Scope,Alon;Geller,AlanC;Marghoob,AshfaqA;Halpern,AllanC
• 通讯作者: Halpern,AllanC

The study of nevi in children: Principles learned and implications for melanoma diagnosis.

• DOI: 10.1016/j.jaad.2016.03.027
• 发表时间: 2016-10
• 期刊: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
• 影响因子: 13.8
• 作者: Scope, Alon;Marchetti, Michael A.;Marghoob, Ashfaq A.;Dusza, Stephen W.;Geller, Alan C.;Satagopan, Jaya M.;Weinstock, Martin A.;Berwick, Marianne;Halpern, Allan C.
• 通讯作者: Halpern, Allan C.

Study of Nevi in Children (SONIC): baseline findings and predictors of nevus count.

儿童痣研究 (SONIC)：痣数量的基线发现和预测因素。

• DOI: 10.1093/aje/kwn289
• 发表时间: 2009
• 期刊: American journal of epidemiology
• 影响因子: 5
• 作者: Oliveria,SusanA;Satagopan,JayaM;Geller,AlanC;Dusza,StephenW;Weinstock,MartinA;Berwick,Marianne;Bishop,Marilyn;Heneghan,MaureenK;Halpern,AllanC
• 通讯作者: Halpern,AllanC