Association among serum perfluroalkyl chemicals,chronic kidney disease and cardio

血清全氟烷基化学物质与慢性肾病和心脏病之间的关系

基本信息

批准号：
8081796
负责人：
Anoop Shankar
金额：
$ 7.25万
依托单位：
WEST VIRGINIA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-06-04 至 2013-05-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This proposal describes a population-based study to examine the relation of blood levels of perfluroalkyl chemicals (PFCs) to the presence of chronic kidney disease (CKD) and cardiovascular disease (CVD) in two separate studies in a population-based sample of Appalachian adults. We are requesting funding for secondary analysis of data. This proposal takes advantage of the data on exposures and outcomes already gathered on a population-based cross-sectional sample of 56,554 Appalachian adults who were aged e18 years and 53% of whom were women, residing in six communities in Ohio and West Virginia, called the C8 Health Study. In the study, we have data available on serum PFC levels, the main exposure of interest, on all members of the cohort, including serum levels of perfluorooctane sulfonate (PFOS or C8s), perfluorooctanoic acid (PFOA or C8), perfluorohexane sulfonate (PFHxS or C6S), perfluorohexanoic acid (PFHxA or C6), perfluoropentanoic acid (PFPeA or C5), perfluoroheptanoic acid (PFHpA or C7), perfluorononaoic acid (PFNA or C9), perfluorodecanoic acid (PFDA or C10), perfluoroundecanoic acid (PFUnA or C11), and perfluorododecanoic acid (PFDoA or C12) as part of a previous court-mandated health survey. We also have available pertinent data that will enable us to define CKD and CVD, the main outcomes of interest. This includes serum creatinine measurement that is available on all study subjects, enabling us to estimate glomerular filtration rate (eGFR), estimated by the Modification of Diet in Renal Disease (MDRD) equation. We will define CKD as an eGFR of <60 mL/min per 1.73 meter2, consistent with current guidelines. We also have data on validated, physician diagnosed CVD, including coronary heart disease and stroke. We will examine the putative association between serum PFCs and the outcomes of interest (CKD or CVD) employing standard epidemiological techniques, including multivariable logistic regression models adjusting for age, gender, race- ethnicity, education, body mass index, and other confounders. Our study provides a unique and cost-effective opportunity to assess the independent association between serum PFC and the presence of CVD and CKD in a large community-based cohort in Appalachia, which is a designated health disparity population. Data from our study will improve the understanding of the health effects of PFCs on humans. Results from the current study will also guide the planning of future follow-up studies of the same cohort population. PUBLIC HEALTH RELEVANCE: Perfluroalkyl chemicals (PFC) are detectable in the blood of >98% of S adults. We will study the association between blood PFCs and kidney disease and cardiovascular disease. If we find an association, it indirectly suggests that reducing PFCs may have a role in preventing these diseases.

描述（由申请人提供）：该提案描述了一项基于人群的研究，旨在检查全氟烷基化学物质 (PFC) 的血液水平与慢性肾病 (CKD) 和心血管疾病 (CVD) 存在的关系，该研究是在一项独立的研究中进行的。基于人口的阿巴拉契亚成年人样本。我们正在请求资金用于数据的二次分析。该提案利用了基于人群的横截面样本中已经收集的暴露和结果数据，该样本包括 56,554 名年龄在 18 岁以下的阿巴拉契亚成年人，其中 53% 是女性，居住在俄亥俄州和西弗吉尼亚州的六个社区，称为C8 健康研究。在这项研究中，我们获得了队列中所有成员的血清 PFC 水平（主要关注暴露）的数据，包括全氟辛烷磺酸（PFOS 或 C8s）、全氟辛酸（PFOA 或 C8）、全氟己烷磺酸（PFHxS）的血清水平或 C6S）、全氟己酸（PFHxA 或 C6）、全氟戊酸（PFPeA 或 C5）、全氟庚酸（PFHpA 或 C7）、全氟壬酸（PFNA 或 C9）、全氟癸酸（PFDA 或 C10）、全氟十一烷酸（PFUnA 或 C11）和全氟十二烷酸（PFDoA 或 C12）作为先前法院强制健康调查的一部分。我们还拥有可用的相关数据，使我们能够定义 CKD 和 CVD（我们感兴趣的主要结果）。这包括所有研究对象均可进行的血清肌酐测量，使我们能够估计肾小球滤过率 (eGFR)，通过肾病饮食修改 (MDRD) 方程估计。我们将 CKD 定义为 eGFR <60 mL/min 每 1.73 米2，与当前指南一致。我们还有经过验证的、医生诊断的 CVD 数据，包括冠心病和中风。我们将采用标准流行病学技术，包括调整年龄、性别、种族、教育程度、体重指数和其他混杂因素的多变量逻辑回归模型，检查血清 PFC 与目标结果（CKD 或 CVD）之间的假定关联。我们的研究提供了一个独特且具有成本效益的机会，用于评估阿巴拉契亚地区大型社区队列中血清 PFC 与 CVD 和 CKD 存在之间的独立关联，阿巴拉契亚地区是指定的健康差异人群。我们的研究数据将增进人们对 PFC 对人类健康影响的了解。当前研究的结果还将指导未来对同一队列人群的后续研究的规划。公共卫生相关性：> 98% 的成年人的血液中可检测到全氟烷基化学物质 (PFC)。我们将研究血液 PFC 与肾脏疾病和心血管疾病之间的关联。如果我们发现两者之间存在关联，则间接表明减少 PFC 可能有助于预防这些疾病。