CANCER TISSUE AND PATHOLOGY SHARED RESOURCE

癌症组织和病理学共享资源

• 批准号: 8710554
• 负责人: DANIEL J BRAT
• 金额: $ 0.23万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8710554
• 关键词: Anatomy; Animal Model; Basic Science; Blood; Cancer Center Support Grant; Categories; Child; Clinical; Clinical Research; Collaborations; Consent; Epidemiologic Studies; Equipment; Equipment and supply inventories; Floor; Freezing; Grant; Healthcare; Human; Human Resources; Individual; Institutes; Institutional Review Boards; Investigation; Laboratories; Lasers; Leadership; Malignant Neoplasms; Microscopy; Mission; Pathology; Patients; Preparation; Procedures; Process; Productivity; Protocols documentation; Research; Research Personnel; Resource Sharing; Resources; Role; Sampling; Scanning; Science; Services; Site; Slide; Source; Specimen; Staining method; Stains; Support Groups; The Cancer Genome Atlas; Tissue Banking; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Tumor Bank; University Hospitals; Work; base; cancer Biomedical Informatics Grid; digital; experience; human disease; human tissue; member; programs; quality assurance; repository; success; tissue processing; tool; tumor

The Cancer Tissue and Pathology Shared Resource (Category 4.06) is critical to the clinical and scientific success of the Winship Cancer Institute because of its central role in facilitating tissue-based investigation though the procurement of human cancer specimens and comprehensive histopathologic services. The Resource is highly integrated, serving individual and team projects in all of the major programs and interfacing directly with the other Shared Resources. The tissue banking component consists of an IRB approved Human Tissue Procurement Service (HTPS), located within the Emory University Hospital and Winship, with affiliated banking sites at Grady Memorial, Emory Midtown and Children's Healthcare of Atlanta at Egleston. Procurement personnel are experienced in anatomic pathology and tumor banking protocols with quality assurance provided by members of the Department of Pathology. Tumor, normal control tissues and blood, along with other biospecimens on specialized protocols, are procured according to standardized operating procedures as frozen, fresh, fixed, embedded or other specialized preparation, and inventoried in caTissue Core, a caBIG tool for biospecimen repositories. Over 55,000 specimens are available. Tissues are distributed to Winship investigators with IRB-approved protocols to advance clinical, translational, basic and epidemiologic research. Pathology services are provided by the Research Pathology Laboratory, a full service lab located on the 5th floor of the Winship building with experienced personnel and equipment for tissue processing, histological and immunohistochemical staining, laser capture microscopy, tissue microarrays and a whole slide scanning for digital pathology. The lab processes large volumes of samples derived from human disease and animal models and works in close collaboration with the other Shared Resources and scientific programs of Winship, as demonstrated by research productivity and support of group science grants. The growing success of this Shared Resource is highlighted by its leadership in multiple NCI-driven initiatives, including caBIG, TCGA and caHUB. This Shared Resource provides centralized, efficient and high quality services that are not duplicated by other facilities on campus.

癌症组织和病理共享资源（4.06级）对于Winship Cancer Institute的临床和科学成功至关重要，因为它在促进基于组织的研究中的核心作用，尽管采购了人类癌症标本和全面的组织病理学服务。资源是高度集成的，在所有主要计划中为个人和团队项目提供服务，并直接与其他共享资源接口。组织银行的组成部分由位于埃默里大学医院和Winship内的IRB认可的人类组织采购服务（HTPS）组成，并在Egleston的Emory Midtown，Emory Midtown和Atlanta的儿童医疗保健中有关联银行地点。采购人员在解剖病理学和肿瘤银行方案方面经验丰富，并由病理部成员提供的质量保证。肿瘤，正常对照组织和血液以及其他在专门方案上的生物测量，根据标准化的操作程序采购，作为冷冻，新鲜，固定，嵌入式或其他专业制剂，并在Catissue Core（一种生物胶质细胞存储库的Cabig core）中库存。有超过55,000个标本可用。组织分配给具有IRB批准方案的Winship研究人员，以推动临床，转化，基本和流行病学研究。病理服务由研究病理实验室提供，该研究病理实验室是一个完整的服务实验室，位于Winship建筑物的5楼，具有经验丰富的人员和设备，用于组织处理，组织学和免疫组织化学染色，激光捕获显微镜，组织微阵列以及用于数字病理学的整个幻灯片扫描。实验室处理 大量的样本来自人类疾病和动物模型，并与其他共享资源和胜利的科学计划密切合作，这是研究生产力和团体科学补助金的支持所证明的。该共享资源的成功越来越多，其在包括Cabig，TCGA和Cahub在内的多个NCI驱动计划中的领导力强调了。这种共享资源提供了集中，高效和高质量的服务，这些服务不会被校园其他设施重复。