Role of the midline thalamus in arousal, attention and cognition

中线丘脑在唤醒、注意力和认知中的作用

基本信息

批准号：
8573930
负责人：
ROBERT Paul Vertes
金额：
$ 42.34万
依托单位：
FLORIDA ATLANTIC UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2018-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8573930
关键词：
Affect Affective Arousal Attention Awareness Behavior Behavioral Brain Brain Stem Brain region Cell Nucleus Cells Cognition Cognitive Coma Communication Conscious Consciousness Disorders Deep Brain Stimulation Emotional Environment Epilepsy Excitotoxic lesion Frequencies Hippocampus (Brain)Human Injection of therapeutic agent Ketamine Laboratories Learning Lesion Limbic System Long-Term Potentiation Medial Mediating Memory Midline Thalamic Nuclei Minimally Conscious States Modeling Motor N-Methylaspartate Output Patients Physiological Positioning Attribute Prefrontal Cortex Property Prosencephalon Rattus Research Reuniens Thalamic Nucleus Role Schizophrenia Signal Transduction Site Structure Sum Synapses System Testing Thalamic structure base cognitive function expectation memory process novel public health relevance research study

项目摘要

DESCRIPTION (provided by applicant): Nuclei lying on the midline of the thalamus (midline nuclei) receive afferent information from regions of the brain that exert activating effects on behavior and on the electrical activity of the cortex. The midline nuclei, in turn, send projection to structures of the forebrain that participate in emotional and cognitive behavior which collectively constitute the limbic system. Two prominent distribution sites of the nucleus reuniens (RE) of the midline thalamus are the hippocampus and medial prefrontal cortex. Both structures serve a prominent role in various aspects of memory. Based on its diverse set of afferents and selective output to structures of the limbic forebrain, the midline nuclei of thalamu appear to serve a prominent role in affective and cognitive functions, perhaps by mediating the effects of arousal/attention on cognitive behavior. In this regard, it is well recognized that destruction of the midline thalamus in humans produces coma; and its partial disruption gives rise to a condition termed the minimally conscious state (MCS) -- or one in which patients are conscious but generally unaware and unresponsive to their surroundings. Schiff and colleagues demonstrated the remarkable findings that deep brain stimulation (DBS) of the midline thalamus in MCS patients restored a range of motor and cognitive functions that had long been dormant (or absent). Surprisingly, despite its apparent direct involvement in a host of limbic-related functions, comparatively little research has been done on the RE/midline thalamus. A few recent studies have shown, however, that lesions of nucleus reuniens in rats severely disrupt learning and memory. We suggest that the RE/midline thalamus represent a critical node in communication between 'lower' and 'higher' regions of the limbic system and among structures of the limbic forebrain. We intend to examine the midline thalamus, and particularly nucleus reuniens (RE), from diverse perspectives with the objective of determining its contribution to affective and cognitive functions. Specifically, with three sets of experiments, we intend to characterize: (1) the effects of selective RE lesions on learning and memory - or on hippocampal- or mPFC-dependent functions; (2) the effects of reversible inactivation of RE on place cell activity in the hippocampus with the aim of determining the contribution of RE to place cell stability and hence to spatial memory; and (3) the potentiating effects of RE stimulation on entorhinal cortical-elicited long term potentiation (LTP) at CA1 of the hippocampus and on hippocampal-elicited LTP at the mPFC. In sum, these studies should provide critical information on the modulatory effects of RE on the limbic forebrain in the control of arousal/attention, affect and cognition with direct implications for disorders of consciousness, schizophrenia and epilepsy.

描述（由申请人提供）：位于丘脑中线（中线核）上的核从大脑区域接收信息，这些信息会激活对行为和皮质的电活动的影响。反过来，中线核将投影发送给参与情感和认知行为的前脑结构，这些结构共同构成了边缘系统。中线丘脑的两个突出的分布位点是海马和内侧前额叶皮层。这两种结构在记忆的各个方面都起着重要的作用。基于其对边缘前脑结构的各种传入和选择性输出，Thalamu的中线核似乎在情感和认知功能中起着重要的作用，也许是通过介导了唤醒/注意力对认知行为的影响。在这方面，人们众所周知，人类中线丘脑的破坏会引起昏迷。它的部分破坏引起了一种被称为最小意识状态（MC）的状况，或者患者有意识但通常对周围环境没有反应和反应。 Schiff及其同事证明了MCS患者中线丘脑的深脑刺激（DB）的显着发现恢复了长期休眠（或不存在）的一系列运动和认知功能。令人惊讶的是，尽管它显然直接参与了许多与边缘相关的功能，但对Re/Midline Thalamus的研究相对较少。然而，最近的一些研究表明，大鼠中核团聚的病变严重破坏了学习和记忆。我们建议Re/Midline Thalamus代表了边缘系统的“下部”和“更高”区域以及边缘前脑结构之间的通信中的关键节点。我们打算从不同的角度检查中线丘脑，尤其是核团圆（RE），目的是确定其对情感和认知功能的贡献。具体而言，通过三组实验，我们打算表征：（1）选择性病变对学习和记忆的影响 - 或对海马或MPFC依赖性功能的影响；（2）RE可逆失活对海马中细胞活性的影响，目的是确定RE对放置细胞稳定性的贡献，从而确定对空间记忆的贡献；（3）重新刺激对海马的CA1和MPFC的海马 - 释放的LTP的CA1上的内嗅皮质释放的长期增强（LTP）的增强作用。总而言之，这些研究应提供有关RE对唤醒/注意的边缘前脑的调节作用的关键信息，影响和认知对意识，精神分裂症和癫痫的疾病的直接影响。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The reuniens and rhomboid nuclei: neuroanatomy, electrophysiological characteristics and behavioral implications.

DOI：
10.1016/j.pneurobio.2013.08.006
发表时间：
2013-12
期刊：
Progress in neurobiology
影响因子：
6.7
作者：
Cassel JC;Pereira de Vasconcelos A;Loureiro M;Cholvin T;Dalrymple-Alford JC;Vertes RP
通讯作者：
Vertes RP

Limbic circuitry of the midline thalamus.