Midcareer Mentoring Award for Patient Oriented Research in Geriatric Cardiology

老年心脏病学以患者为导向的研究职业生涯中期指导奖

• 批准号: 8149842
• 负责人: MATHEW S MAURER
• 金额: $ 15.81万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8149842
• 关键词: Accounting; Activities of Daily Living; Address; Admission activity; Adult; Affect; Aging; American; Anemia; Aortic Valve Stenosis; Applications Grants; Award; Cardiac; Cardiac Output; Cardiology; Cardiopulmonary; Cardiovascular Diseases; Cardiovascular system; Caring; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Design; Commit; Coronary Arteriosclerosis; Data; Data Analyses; Development; Diagnosis; Diastolic heart failure; Disease; EFRAC; Educational Curriculum; Effectiveness; Elderly; Environment; Erythropoietin; Ethics; Exercise stress test; Faculty; Fatigue; Fostering; Functional disorder; Funding; Future; Generations; Genetic; Geriatrics; Goals; Grant; Health Care Costs; Health Status; Heart Diseases; Heart failure; Hospitalization; Hypertension; Incidence; Individual; Institutes; Internal Medicine; Intervention; Investigation; Measures; Mechanics; Medical Education; Mentors; Midcareer Investigator Award in Patient-Oriented Research; Myocardial; New York; Outcome; Patient Self-Report; Patients; Performance; Peripheral; Phenotype; Physiological; Population; Population Heterogeneity; Prevalence; Procedures; Prognostic Factor; Property; Protocols documentation; Public Health; Public Health Schools; Pump; Research; Research Personnel; Social support; Structure; Subgroup; Symptoms; Syndrome; Testing; Time; Training; United States; Universities; Vasodilation; Ventricular; Ventricular Function; Writing; actigraphy; age related; aortic valve replacement; base; career; career development; frailty; hemodynamics; improved; innovation; interest; kidney vascular structure; mortality; multidisciplinary; next generation; outcome forecast; patient oriented research; pilot trial; population based; pressure; programs; public health relevance; skills

DESCRIPTION: The applicant's academic career demonstrates a longterm commitment to patientoriented research, extensive expertise in the study of the pathophysiology of age related cardiovascular disorders that disproportionately afflict older adults including heart failure with preserved systolic function and a successful record in mentoring residents, cardiology fellows and junior faculty in geriatrics and cardiology. The career plan of the applicant is to expand his research interests to multidisciplinary studies of age related cardiovascular conditions by focusing on heart failure with a normal ejection fraction, which accounts for more than half of the cases of heart failure in the United States and that afflicts predominately older adults. During the tenure of this award, the applicant will gain further training in genetics through formal coursework at the Mailman School of Public Health, strengthen existing and form new collaborative relationships with basic and clinical investigators at Columbia University, and institute a successful mentoring program for young clinical investigators from geriatrics and cardiology that will foster collaborative interdisciplinary investigations. The latter will be achieved by the creation of the Greater New York Geriatric Cardiology Consortium (GNYGCC) aimed at improving the care of older adult patients with cardiovascular disease by organizing and delivering a curriculum in geriatric cardiology as part of professional medical education activities and subsequently by performing innovative, investigatorinitiated, multicenter collaborative clinical investigation. The proposed mentoring program consists of three other components: 1) intensive individualized training in patientoriented research; 2) Columbia University didactic programs on clinical trial design, data analysis, grant writing, and ethics; 3) critical review by a team of patient oriented research experts. Awarding a Midcareer Investigator Award in Patient Oriented Research will provide critically needed protected time to achieve these career goals. Columbia provides a strong institutional environment for support of the applicant's career development. The Department of Internal Medicine and Division of Cardiology have committed to protect e50% of the applicant's time for patientoriented research and mentoring. The proposed aims are to evaluate: (1) whether targeting anemia, one of many extracardiac factors that could contribute to the syndrome of HFNEF, is associated with improved ventricular function, functional capacity and health status. (2) for potential differences in pathophysiologic mechanisms that cause or contribute to anergia (lack of energy) in heart failure subjects stratified by a preserved or a reduced ejection fraction and (3) ventricular mechanics and functional capacity using use of noninvasive pressure volume analysis and actigraphy in older adults undergoing percutaneous aortic valve replacement. The proposed studies will advance applicant career development and provide a mechanism by which trainees can acquire the necessary skills to launch a research career and collect data to support grant applications. The ultimate goal is to facilitate the development of a new generation of investigators from both cardiology and geriatrics that can pursue clinical research in the arena of aging cardiovascular disease. PUBLIC HEALTH RELEVANCE: Cardiovascular Disease remains the leading cause of mortality in the United States with a majority of those afflicted being older adults. The broad goal of this program is to train the next generation of academic clinical cardiovascular investigators who will focus on cardiovascular disorders that disproportionately afflict older adults in order to improve the outcomes among these individuals.

描述：申请人的学术生涯表明了对以患者为中心的研究的长期承诺，在与年龄相关的心血管疾病的病理生理学研究方面拥有丰富的专业知识，这些疾病尤其困扰老年人，包括保留收缩功能的心力衰竭，并在指导住院医师、心脏病学研究员和老年病学和心脏病学初级教师。申请人的职业计划是将他的研究兴趣扩展到与年龄相关的心血管疾病的多学科研究，重点关注射血分数正常的心力衰竭，这种心力衰竭占美国心力衰竭病例的一半以上，并且困扰着射血分数正常的心力衰竭患者。主要是老年人。在该奖项任职期间，申请人将通过梅尔曼公共卫生学院的正式课程获得进一步的遗传学培训，加强与哥伦比亚大学基础和临床研究人员的现有合作关系并形成新的合作关系，并为年轻人制定成功的指导计划来自老年病学和心脏病学的临床研究人员将促进跨学科合作研究。后者将通过创建大纽约老年心脏病学联盟 (GNYGCC) 来实现，该联盟旨在通过组织和提供老年心脏病学课程作为专业医学教育活动的一部分，并随后通过进行创新的、研究者发起的、多中心协作的临床研究。拟议的指导计划包括其他三个部分：1）以患者为导向的研究的强化个性化培训； 2) 哥伦比亚大学关于临床试验设计、数据分析、资助写作和伦理学的教学项目； 3) 由以患者为中心的研究专家团队进行严格审查。授予以患者为导向的研究领域的职业中期研究员奖将为实现这些职业目标提供急需的受保护时间。哥伦比亚为申请人的职业发展提供了强大的制度环境。内科和心脏病科承诺保护申请人 50% 的时间用于以患者为导向的研究和指导。拟议的目的是评估：（1）针对贫血（可能导致 HFNEF 综合征的众多心外因素之一）是否与改善心室功能、功能能力和健康状况相关。 (2) 通过射血分数保留或降低分层的心力衰竭受试者中导致或导致无能（缺乏能量）的病理生理机制的潜在差异，以及 (3) 使用无创压力容量分析和 (3) 心室力学和功能能力接受经皮主动脉瓣置换术的老年人的体动记录仪。拟议的研究将促进申请人的职业发展，并提供一种机制，使受训者能够获得开展研究职业所需的技能并收集数据以支持资助申请。最终目标是促进心脏病学和老年医学领域新一代研究人员的发展，他们可以在老年心血管疾病领域进行临床研究。 公共卫生相关性：心血管疾病仍然是美国死亡的主要原因，其中大多数患者是老年人。该计划的总体目标是培训下一代学术临床心血管研究人员，他们将重点关注不成比例地困扰老年人的心血管疾病，以改善这些人的治疗结果。