Development of near-infrared spectroscopy to study drug addiction

近红外光谱技术的发展用于研究药物成瘾

• 批准号: 8600477
• 负责人: SUSAN L ANDERSEN
• 金额: $ 19.75万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8600477
• 关键词: Address; Adult; Age; Animal Model; Animals; Award; Basic Science; Behavioral; Benchmarking; Blood; Blood flow; Brain; Brain region; Cerebral cortex; Cocaine; Cues; Development; Devices; Discipline; Drug Addiction; Drug abuse; Electrical Engineering; Electrophysiology (science); Fiber; Fright; Functional Imaging; Functional Magnetic Resonance Imaging; Goals; Head; Hemoglobin; Human; Imagery; Imaging Device; Implant; In Situ; Intravenous; Knowledge; Laboratories; Light; Location; Magnetic Resonance; Magnetic Resonance Imaging; Mammals; Measurement; Measures; Miniaturization; Monitor; Morphologic artifacts; Movement; Near-Infrared Spectroscopy; Neurons; Neurosciences; Odors; Optics; Pattern; Pharmaceutical Preparations; Physics; Procedures; Process; Property; Rattus; Research; Research Personnel; Rodent; Scalp structure; Self Administration; Self-Administered; Signal Transduction; Specificity; Sum; Techniques; Technology; Time; Translating; Validation; absorption; addiction; awake; behavior measurement; cost; cranium; hemodynamics; implantation; indexing; innovation; innovative technologies; interest; knowledge base; man; meetings; new technology; optical fiber; preclinical study; programs; public health relevance; response; success; technology development

DESCRIPTION (provided by applicant): We propose to advance the use and interpretation of near-infrared spectroscopy (NIRS) technology by determining the faithfulness to which NIRS localizes patterns of blood flow relevant to addiction-related processes. Importantly, these NIRS signals will be simultaneously collected with behavioral measures of addiction (e.g., self-administration) in real-time. Currently, the use of functional magnetic resonance (fMRI) for the study of small mammals is difficult and relatively impractical for the majority of researchers. Our goal is to provide a "poor man's" functional imaging device that will be available for a modest cost and is readily accessible and easy to implement. Simply stated, our intent is to rapidly increase our knowledge base about blood flow changes in animals that could be readily translated to understanding human processing of drug-related information. In the proposed research, we will use a multi-faceted approach including NIRS, MFI, and intravenous self- administration of cocaine to determine whether localized assessment with NIRS is a useful alternative to fMRI to determine changes in blood flow. We will extend the utility of the NIRS approach to freely moving animals that are actively self-administering cocaine. Both the significance and innovation of this approach is relevant for the CEBRA due to the development of innovative technology to rapidly advance our understanding of blood flow change in animal models. Aims Proposed: * Specific Aim 1. To establish the similarities in blood flow changes detected by fMRI and NIRS. * Specific Aim II: To determine whether we can use NIRS to monitor neuronal activity in real-time in freely moving animals.

描述（由申请人提供）：我们建议通过确定 NIRS 定位与成瘾相关过程相关的血流模式的忠实度来推进近红外光谱 (NIRS) 技术的使用和解释。重要的是，这些 NIRS 信号将与成瘾行为测量（例如自我给药）同时实时收集。目前，对于大多数研究人员来说，使用功能磁共振（fMRI）来研究小型哺乳动物是困难且相对不切实际的。我们的 目标是提供一种“穷人的”功能性成像设备，其成本适中，并且易于获取和实施。简而言之，我们的目的是快速增加我们关于动物血流变化的知识库，这些知识库可以很容易地转化为理解人类对药物相关信息的处理。在拟议的研究中，我们将使用多方面的方法，包括 NIRS、MFI 和静脉自我注射可卡因，以确定 NIRS 的局部评估是否可以替代功能磁共振成像来确定血流变化。我们将把 NIRS 方法的实用性扩展到那些主动自我施用可卡因的自由活动的动物。这种方法的重要性和创新性都与 CEBRA 相关，因为创新技术的发展可以迅速增进我们对动物模型血流变化的理解。拟议目标： * 具体目标 1. 确定 fMRI 和 NIRS 检测到的血流变化的相似性。 * 具体目标 II：确定我们是否可以使用 NIRS 实时监测自由活动动物的神经元活动。