Structural Stability of Carotid Plaque and Symptomatology

颈动脉斑块的结构稳定性和症状学

• 批准号: 8416383
• 负责人: ROBERT J DEMPSEY
• 金额: $ 30.08万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-15 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8416383
• 关键词: Address; Affect; Aging; American; Area; Arterial Fatty Streak; Atherosclerosis; Atrophic; Blood Vessels; Brain; Cardiac; Carotid Artery Plaques; Carotid Atherosclerotic Disease; Carotid Endarterectomy; Cerebrovascular Circulation; Cerebrovascular Disorders; Cerebrum; Characteristics; Cholesterol; Clinical; Cognition; Cognitive; Defect; Deposition; Development; Disease; Distal; Elasticity; Embolism; Endarterectomy; Functional disorder; Future; Health; Hemorrhage; Histopathology; Human; Impaired cognition; Individual; Injury; Ipsilateral; Ischemia; Lead; Magnetic Resonance Imaging; Measurable; Measurement; Measures; Mechanics; Methods; Motion; Motor; Operative Surgical Procedures; Patient Monitoring; Patients; Perfusion; Relative (related person); Risk; Role; Sensory; Side; Site; Source; Specimen; Speech; Spin Labels; Stroke; Surface; Symptoms; System; Therapeutic Embolization; Thrombosis; Thrombus; Time; Ulcer; Ultrasonography; Vision; aging population; angiogenesis; cerebral atrophy; clinically relevant; gray matter; ischemic lesion; novel marker; prevent; public health relevance; treatment strategy; white matter

DESCRIPTION (provided by applicant): This study examines the issue of "silent" strokes in the relationship between the structural stability of atherosclerotic carotid plaque and the development of nonmotor symptomatology, including brain atrophy and cognitive decline. It addresses the question of the role of carotid emboli in "silent" stroke and their cognitive sequelae. The study uses human carotid endarterectomy patients to study three specific aims. The first uses ultrasound to relate plaque elasticity and its development of mechanical strain features with pulsation and the histopathophysiology of the plaque for ulcer, hemorrhage and thinning of stabilizing fibrous cap at the point of these mechanical strain features. The second examines ultrasound detected elasticity strain features in the plaques and the presence of transcranial Doppler TCD detectable microemboli. The third looks at ultrasound strain deficits, microemboli, cognitive decline and brain MRI evidence of focal and generalized atrophy. Understanding the structural plaque abnormalities, which render a carotid plaque mechanically unstable and at risk of embolization will demonstrate a pathophysiologic mechanism in individuals who are likely to suffer not only classic episodic major strokes, but also functional progressive decline from the contribution of microemboli to cerebral "silent" stroke and cognitive decline.

描述（由申请人提供）：本研究研究了动脉粥样硬化颈动脉斑块的结构稳定性与非运动症状的发展之间的“无声”中风问题，包括脑萎缩和认知能力下降。它解决了颈动脉栓塞在“沉默”中风和他们的认知后遗症中的作用的问题。该研究使用人类颈动脉内膜切除术患者研究三个特定目标。第一个使用超声将斑块弹性及其开发机械应变特征与脉动的发展以及斑块的组织病理生理学在这些机械应变特征的点上进行溃疡，出血和稳定纤维帽的变薄。第二个检查了斑块中检测到的弹性应变特征以及经颅多普勒TCD可检测到的微栓塞的弹性应变特征。第三次查看超声应变缺陷，微栓塞，认知下降和脑MRI的局灶性萎缩证据。了解结构性斑块异常，从而使颈动脉斑块机械地不稳定并有栓塞风险，这将证明那些可能不仅遭受经典的情节性主要中风的人的病理生理机制，而且还遭受了经典的功能性逐步逐步逐步逐步降低，从而从微骨对脑性“无声”的“无声”的“无声”势力降低了。