University of Montreal Cardiac Surgery Clinical Investigation Group

蒙特利尔大学心脏外科临床研究组

基本信息

批准号：
8657306
负责人：
Louis Paul Perrault
金额：
$ 5.92万
依托单位：
MONTREAL HEART INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2013-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Despite improvements in cardiac surgery and anesthesia in the face of sicker and elderly patients, numerous ssues remain to be clarified concerning the best treatment options for ischemic mitral valve regurgitation and novel therapy for pulmonary hypertension. These important questions are difficult to answer with single center trials even in centers with a high volume of complex valvular surgery. The NIH has decided to form a network of clinical centers to address this challenge. The U of Montreal Cardiac Surgery Clinical Investigation Group (UMCSCIG) is proposing to join the NIH Network to help attain its goals of bringing innovative experimental strategies for the treatment of cardiac surgical pathology from the laboratory to the bedside. The U of M investigation Group is made up of 3 tertiary university hospital centers on 5 sites in the city of Montreal, treating over 3000 patients by 17 surgeons which represents close to 50% of the cardiac surgical volume of the Province of Quebec (population 8 million). The Group has a number of special attributes, and brings with it expertise that would be helpful for the NIH network as a whole. Its members belong to a single payer socialized medicine system, which facilitates patient follow-up and data generation. The close collaboration of cardiac surgical investigators with extensive experience in clinical trials with cardiologists, clinician-scientists and basic researchers within the research centers of the 3 hospital centers by their affiliation to the University of Montreal plus the hook-up with the Canadian East-West Network and the Quebec Heart Failure Society dedicated to Heart Failure Research are definite advantages. The MHI has a long and successful tradition of working with the NIH, it has an experienced clinical research co-ordinating center. The group has access to state of the art investigative technology, expertise in blood sampling, transportation and performs a large spectrum of open and minimally invasive coronary, valvular and aortic surgery as well as heart transplantation and implantable artificial heart program and emerging strength in cell therapy and seven new hybrid technology operating rooms are currently under construction at MHI. The U of Montreal Research Group proposes a project to evaluate the effect of a new treatment option for severe ischemic mitral regurgitation and a second project test a new pharmacological management of pulmonary hypertension in patients experiencing difficult separation from cardiopulmonary bypass. (End of Abstract)

描述（由申请人提供）：尽管面对病人和老年患者的心脏外科手术和麻醉有所改善，但有关缺血性二尖瓣瓣膜反流的最佳治疗方法和新颖的肺动脉高压疗法，仍有许多SSUS尚待阐明。即使在具有大量复杂瓣膜手术的中心，这些重要问题也很难通过单中心试验来回答。 NIH已决定建立一个临床中心网络，以应对这一挑战。蒙特利尔心脏手术临床研究小组（UMCSCIG）的U U型提议加入NIH网络，以帮助实现其实现创新的实验策略，以将心脏手术病理学从实验室从实验室延伸到床边。 M调查小组由3个三级医院医院中心组成，位于蒙特利尔市的5个地点，17位外科医生对3000多名患者进行了治疗，占魁北克省心脏手术量的50％（人口800万）。该小组具有许多特殊属性，并带有IT专业知识，这对整个NIH网络都会有所帮助。它的成员属于单一付款人社会化医学系统，该系统有助于患者的随访和数据生成。心脏外科手术研究人员的密切合作与心脏病专家，临床医生，科学家和基础研究人员在3个医院中心的研究中心内与蒙特利尔大学的研究中心内的临床试验进行了丰富的合作，并与加拿大东部网络以及魁北克心力衰竭社会致力于心脏失败的社会致力于心脏失败研究。 MHI具有与NIH合作的悠久而成功的传统，它具有经验丰富的临床研究协调中心。该小组可以使用现状调查技术，血液采样，运输方面的专业知识，并进行大量开放且微创的冠状动脉，瓣膜和主动脉手术以及心脏移植以及可植入的人造心脏计划以及在MHI建造的七个新型混合技术手术室。蒙特利尔研究小组提出了一个项目，以评估一种新的治疗方案对严重缺血性二尖瓣反流的影响和第二个项目测试，一种对从心肺旁路的困难分离的患者中对肺动脉高压的新药理管理。（抽象的结尾）