Improving Cognitive Outcome Precision & Responsiveness with Modern Psychometrics

提高认知结果的精确度

• 批准号: 8120681
• 负责人: Paul K Crane
• 金额: $ 54.1万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8120681
• 关键词: Abbreviations; Accounting; Address; Age; Alzheimer' s Disease; Auditory; Benchmarking; Biological Markers; Boston; California; Clinical; Clinical Research; Clinical Trials; Cognition; Cognitive; Cognitive aging; Data; Data Analyses; Data Set; Dementia; Disease; Education; Evaluation; Future; Gender; Growth; Hippocampus (Brain); Image; Individual; Intervention; Link; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Memory; Metabolic; Methods; Modality; Modeling; National Institute on Aging; Neuropsychological Tests; Outcome; Persons; Positron; Process; Program Research Project Grants; Psychometrics; Randomized Controlled Trials; Receiver Operator Characteristics; Rehabilitation Centers; Reporting; Research; Research Personnel; Sample Size; Scientific Evaluation; Screening procedure; Simulate; Site; Specific qualifier value; Structure; Techniques; Test Result; Testing; Time; Universities; Vascular Dementia; Washington; Work; aged; base; clinically relevant; cognitive function; cost; design; drug discovery; executive function; improved; instrument; literacy; mental state; mild neurocognitive impairment; neuroimaging; neuropsychological; normal aging; prevent; programs; prospective; response; simulation; subcortical ischemic vascular disease; theories; time use; tool; web site

DESCRIPTION (provided by applicant): The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a $60 million, multi-site, longitudinal, prospective, naturalistic study of individuals with normal cognitive aging, mild cognitive impairment (MCI), and early Alzheimer's disease (AD) to facilitate the scientific evaluation of neuroimaging and other markers for the onset and progression of MCI and AD. Tests of cognitive functioning provide the benchmark for comparison in ADNI. A major limitation of the ADNI project is that modern psychometric analyses are not applied. Our group of investigators from the University of Washington, the University of California Davis, Washington University in St. Louis, and the Hebrew Rehabilitation Center for the Aged in Boston intend to address this limitation to determine those methods best able to detect and measure important changes over time. We will combine analyses of ADNI data with analyses of data from the Subcortical Ischemic Vascular Disease Program Project Grant (Helena Chui, PI) to pursue the following specific aims: Aim 1. Develop strategies for measuring change over time in subjects with normal aging, MCI, and AD using modern psychometric methods applied to neuropsychological data from ADNI and SIVD PPG. Aim 2. Evaluate modern psychometric methods for measuring change over time, and compare with conventional analyses using simulated and real data. Aim 3. Develop and evaluate strategies for combining neuropsychological, neuroimaging, and biomarker data into composite outcomes for randomized controlled trials (RCTs) of interventions to prevent and treat MCI and AD. Aim 4. Develop clinically useful score reports for the Uniform Data Set (UDS) to summarize general cognition, memory, and executive functioning, accounting for DIP and measurement error. We will test several hypotheses and hope to illustrate statistical techniques for optimizing the robustness of the psychometric data that will be collected in future clinical trials, whether alone or in conjunction with imaging.

描述（由申请人提供）：阿尔茨海默病神经影像计划 (ADNI) 是一项耗资 6,000 万美元的多中心、纵向、前瞻性、自然主义研究，对象为正常认知衰老、轻度认知障碍 (MCI) 和早期阿尔茨海默病 (AD) 患者。 ）以促进对 MCI 和 AD 发病和进展的神经影像学和其他标志物进行科学评估。认知功能测试为 ADNI 中的比较提供了基准。 ADNI 项目的一个主要限制是没有应用现代心理测量分析。我们来自华盛顿大学、加州大学戴维斯分校、圣路易斯华盛顿大学和波士顿希伯来老年人康复中心的研究小组打算解决这一局限性，以确定最能检测和衡量重要变化的方法随着时间的推移。我们将对 ADNI 数据的分析与皮质下缺血性血管疾病计划项目资助（PI，Helena Chui）的数据分析结合起来，以实现以下具体目标： 目标 1. 制定测量正常衰老、MCI 受试者随时间变化的策略和 AD，使用现代心理测量方法应用于 ADNI 和 SIVD PPG 的神经心理学数据。目标 2. 评估测量随时间变化的现代心理测量方法，并与使用模拟和真实数据的传统分析进行比较。目标 3. 制定和评估策略，将神经心理学、神经影像学和生物标志物数据结合到预防和治疗 MCI 和 AD 干预措施的随机对照试验 (RCT) 的复合结果中。目标 4. 为统一数据集 (UDS) 开发临床上有用的评分报告，以总结一般认知、记忆和执行功能，并考虑 DIP 和测量误差。我们将测试几个假设，并希望阐明统计技术，以优化未来临床试验中收集的心理测量数据的稳健性，无论是单独的还是与成像相结合。