Role of neural variation in hippocampal coding and plasticity

神经变异在海马编码和可塑性中的作用

• 批准号: 8141346
• 负责人: STEPHEN G LISBERGER
• 金额: $ 17.79万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8141346
• 关键词: Adult; Animals; Area; Behavior; Behavioral; Binding; Biological Models; Brain; Cells; Child; Code; Complex; Computer Simulation; Cues; Development; Environment; Equilibrium; Event; Exhibits; Exposure to; Functional disorder; Future; Hippocampal Formation; Hippocampus (Brain); Human; Impairment; Individual; Interneurons; Investigation; Label; Learning; Location; Memory; Neurons; Output; Pattern; Plastics; Play; Positioning Attribute; Process; Psyche structure; Rattus; Research Personnel; Rodent; Role; Schizophrenia; Signal Transduction; Structure; System; Testing; Time; Variant; behavior influence; entorhinal cortex; experience; memory process; neocortical; novel; prospective; relating to nervous system; transmission process

Numerous researchers have shown that, in humans, the hippocampal formation is necessary for the formation of new memories of facts or events. In rodents these same structures play an essential role in an animal's ability to learn about and remember complex associations, including tasks where the animal must learn and remember information about a set of spatial cues in order to navigate through an environment. Both event / fact memory in humans and spatial memory in rodents requires learning complex relationships, and that parallel strongly suggests that qualitatively similar processing occurs in the human and the rat hippocampus, making the rat hippocampus an attractive model system for investigating memory processing. Memory storage and recall require a balance between seemingly contradictory requirements: the system must be sufficiently plastic to allow new patterns of activity to be rapidly stored, yet sufficiently stable to allow previously stored memories to be retrieved without great distortion. The aim of this proposal is to compare neural variability among the inputs to the hippocampus, the hippocampus itself and the outputs of the hippocampus and to determine whether variability is related to behavior and dynamically regulated during learning. We will test the following hypotheses: 1) the hippocampal circuit creates a low variability representation of space from highly variable inputs, 2) variability in the hippocampal circuit is decreased in the context of memory tasks, and 3) learning causes rapid changes in variability in the hippocampus but slower changes in the downstream deep layers of the entorhinal cortex (EC), reflecting the specialization of the hippocampus for rapid learning and of the deep EC for slower learning of the relationships between locations and behaviors. Integrating our findings with those of the other projects will help us better understand the role of variation in the neural code across brain systems.

许多研究人员表明，在人类中，海马体的形成对于 对事实或事件形成新的记忆。在啮齿动物中，这些相同的结构在 动物学习和记忆复杂关联的能力，包括动物必须完成的任务 学习并记住有关一组空间线索的信息，以便在环境中导航。 人类的事件/事实记忆和啮齿动物的空间记忆都需要学习复杂的关系， 这种平行强烈表明，人类和大鼠中发生了性质相似的处理 海马体，使大鼠海马体成为研究记忆处理的有吸引力的模型系统。 内存存储和调用需要在看似矛盾的要求之间取得平衡：系统 必须具有足够的可塑性，以允许快速存储新的活动模式，但又必须足够稳定，以允许 以前存储的记忆可以在没有很大失真的情况下被检索。该提案的目的是比较 海马体输入、海马体本身以及海马体输出之间的神经变异性 海马体并确定变异性是否与行为相关并在过程中动态调节 学习。我们将测试以下假设：1）海马回路产生低变异性 来自高度可变输入的空间表示，2）海马回路的可变性在 记忆任务的背景，以及3）学习导致海马体变异性的快速变化，但是 内嗅皮层 (EC) 下游深层的变化较慢，反映了 海马体用于快速学习，而深层 EC 则用于较慢学习 地点和行为。将我们的发现与其他项目的发现相结合将帮助我们做得更好 了解大脑系统神经代码变异的作用。