Pediatric Template of Brain Perfusion

儿科脑灌注模板

基本信息

批准号：
8443415
负责人：
Danny JJ WANG
金额：
$ 51.45万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-15 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8443415
关键词：
Address Adolescence Adult Age Atlases Back Base of the Brain Behavioral Blood Blood flow Book Chapters Brain Brain Diseases Brain region Cerebrovascular Circulation Child Childhood Clinical Clinical Research Cognitive Communities Computer software Contrast Media Data Databases Dependence Development Evaluation Evolution Functional Magnetic Resonance Imaging Funding Future Health Hippocampus (Brain)Human Image Image Analysis Imaging Techniques Journals Knowledge Light Longitudinal Studies Magnetic Resonance Angiography Magnetic Resonance Imaging Maps Measurement Measures Methodology Methods Multivariate Analysis National Institute of Mental Health Neurodevelopmental Disorder Neurosciences Parietal Pediatric Hospitals Pediatric Research Peer Review Pennsylvania Performance Perfusion Perfusion Weighted MRI Phase Philadelphia Physiologic pulse Physiological Population Positioning Attribute Prefrontal Cortex Process Productivity Property Protocols documentation Publications Radioisotopes Regional Perfusion Relative (related person)Reproducibility Research Resolution Resources Rest Safety Short-Term Memory Signal Transduction Spin Labels Statistical sensitivity Structure System Technical Expertise Techniques Testing Time Tissues Universities Variant abstracting aged angular gyrus association cortex base bioimaging blood flow measurement blood oxygen level dependent brain tissue cognitive neuroscience design image registration imaging modality improved in vivo indexing morphometry neurogenetics neuroimaging pre-clinical relating to nervous system response

项目摘要

DESCRIPTION (provided by applicant): Project Summary/Abstract The theme of the proposed project is to develop a functional template or atlas of the developing brain based on quantitative cerebral blood flow (CBF) measurements using arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI). Parenchymal perfusion is an important physiologic parameter in the evaluation and management of brain disorders as well as a surrogate index of neural activity. Such information has been sparse in the pediatric population due to the safety concerns and technical difficulties associated with existing methods to measure perfusion that rely on radioisotopes and contrast agents. ASL perfusion MRI is ideally suited for pediatric perfusion imaging, because it is totally noninvasive and provides high image quality due to unique physiologic properties of a child brain. The capability for absolute CBF quantification is another desirable feature of ASL for longitudinal studies to follow neurodevelopmental changes. Through a pilot Human Brain Project funded by NIMH (R21- MH072576, PI: Wang), we have established the feasibility of pediatric perfusion MRI using ASL, and demonstrated the developmental trajectory of CBF in healthy children as well as perfusion aberrations in pre-clinical and clinical pediatric populations. The proposed R01 project represents a continued and systematic effort to address the functional development of a child brain utilizing ASL perfusion MRI. We will first establish the test-retest repeatability and determine the optimal ASL technique along with imaging parameters for constructing the pediatric perfusion template. The accuracy of ASL CBF measurement in children will be validated using global flow rate to the brain determined by phase contrast MRI technique. In the following 4 years, we will develop the normative developmental template of brain perfusion in healthy children aged 7-16 based on ASL perfusion measurements at baseline. In the last aim, we will characterize the quantitative CBF changes in response to a well-characterized cognitive paradigm - working memory tasks - using a concurrent ASL and BOLD (blood-oxygen-level- dependent) fMRI paradigm. Once developed, the pediatric perfusion template will not only shed light on the evolution of brain function with age, but will also provide a valuable resource and reference system for future developmental neuroscience studies as well as clinical studies on childhood brain disorders.

描述（由申请人提供）：项目摘要/摘要拟议项目的主题是基于使用动脉自旋标记（ASL）灌注磁共振成像的定量脑血流量（CBF）测量来开发发育中大脑的功能模板或图谱（核磁共振成像）。脑实质灌注是评估和治疗脑部疾病的重要生理参数，也是神经活动的替代指标。由于依赖放射性同位素和造影剂的现有灌注测量方法存在安全问题和技术困难，此类信息在儿科人群中很少。 ASL 灌注 MRI 非常适合儿科灌注成像，因为它完全无创，并且由于儿童大脑独特的生理特性而提供高图像质量。绝对 CBF 量化的能力是 ASL 的另一个理想特征，可用于追踪神经发育变化的纵向研究。通过NIMH资助的试点人脑项目（R21-MH072576，PI：Wang），我们建立了使用ASL进行儿童灌注MRI的可行性，并展示了健康儿童CBF的发展轨迹以及临床前的灌注畸变。和临床儿科人群。拟议的 R01 项目代表了利用 ASL 灌注 MRI 解决儿童大脑功能发育问题的持续和系统的努力。我们将首先建立重测重复性，并确定最佳 ASL 技术以及用于构建儿科灌注模板的成像参数。儿童 ASL CBF 测量的准确性将使用相差 MRI 技术确定的大脑整体流量进行验证。在接下来的4年里，我们将根据基线ASL灌注测量，开发7-16岁健康儿童脑灌注的规范性发育模板。在最后一个目标中，我们将使用并发的 ASL 和 BOLD（血氧水平依赖）fMRI 范式来表征 CBF 的定量变化，以响应明确的认知范式（工作记忆任务）。一旦开发出来，儿科灌注模板不仅将揭示大脑功能随年龄的演变，还将为未来的发育神经科学研究以及儿童脑部疾病的临床研究提供宝贵的资源和参考系统。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Quantification of Load Dependent Brain Activity in Parametric N-Back Working Memory Tasks using Pseudo-continuous Arterial Spin Labeling (pCASL) Perfusion Imaging.

DOI：
10.17791/jcs.2011.12.2.129
发表时间：
2011-06
期刊：
Journal of cognitive science
影响因子：
0.1
作者：
Q. Zou;H. Gu;Danny J. J. Wang-Danny-J.-J.-Wang-3065062;Jia-Hong Gao;Yihong Yang
通讯作者：
Q. Zou;H. Gu;Danny J. J. Wang-Danny-J.-J.-Wang-3065062;Jia-Hong Gao;Yihong Yang

Noncontrast dynamic MRA in intracranial arteriovenous malformation (AVM), comparison with time of flight (TOF) and digital subtraction angiography (DSA).

DOI：
10.1016/j.mri.2012.02.027
发表时间：
2012-07
期刊：
MAGNETIC RESONANCE IMAGING
影响因子：
2.5
作者：
Yu, Songlin;Yan, Lirong;Yao, Yuqiang;Wang, Shuo;Yang, Mingqi;Wang, Bo;Zhuo, Yan;Ai, Lin;Miao, Xinyuan;Zhao, Jizong;Wang, Danny J. J.
通讯作者：
Wang, Danny J. J.

In-vivo Imaging of Magnetic Fields Induced by Transcranial Direct Current Stimulation (tDCS) in Human Brain using MRI.

DOI：
10.1038/srep34385
发表时间：
2016-10-04
期刊：
Scientific reports
影响因子：
4.6
作者：
Jog MV;Smith RX;Jann K;Dunn W;Lafon B;Truong D;Wu A;Parra L;Bikson M;Wang DJ
通讯作者：
Wang DJ

Relationships between Cerebral Blood Flow and IQ in Typically Developing Children and Adolescents.