Pediatric Template of Brain Perfusion

儿科脑灌注模板

• 批准号: 8443415
• 负责人: Danny JJ WANG
• 金额: $ 51.45万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-15 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8443415
• 关键词: Address; Adolescence; Adult; Age; Atlases; Back; Base of the Brain; Behavioral; Blood; Blood flow; Book Chapters; Brain; Brain Diseases; Brain region; Cerebrovascular Circulation; Child; Childhood; Clinical; Clinical Research; Cognitive; Communities; Computer software; Contrast Media; Data; Databases; Dependence; Development; Evaluation; Evolution; Functional Magnetic Resonance Imaging; Funding; Future; Health; Hippocampus (Brain); Human; Image; Image Analysis; Imaging Techniques; Journals; Knowledge; Light; Longitudinal Studies; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methodology; Methods; Multivariate Analysis; National Institute of Mental Health; Neurodevelopmental Disorder; Neurosciences; Parietal; Pediatric Hospitals; Pediatric Research; Peer Review; Pennsylvania; Performance; Perfusion; Perfusion Weighted MRI; Phase; Philadelphia; Physiologic pulse; Physiological; Population; Positioning Attribute; Prefrontal Cortex; Process; Productivity; Property; Protocols documentation; Publications; Radioisotopes; Regional Perfusion; Relative (related person); Reproducibility; Research; Resolution; Resources; Rest; Safety; Short-Term Memory; Signal Transduction; Spin Labels; Statistical sensitivity; Structure; System; Technical Expertise; Techniques; Testing; Time; Tissues; Universities; Variant; abstracting; aged; angular gyrus; association cortex; base; bioimaging; blood flow measurement; blood oxygen level dependent; brain tissue; cognitive neuroscience; design; image registration; imaging modality; improved; in vivo; indexing; morphometry; neurogenetics; neuroimaging; pre-clinical; relating to nervous system; response; Address; Adolescence; Adult; Age; Atlases; Back; Base of the Brain; Behavioral; Blood; Blood flow; Book Chapters; Brain; Brain Diseases; Brain region; Cerebrovascular Circulation; Child; Childhood; Clinical; Clinical Research; Cognitive; Communities; Computer software; Contrast Media; Data; Databases; Dependence; Development; Evaluation; Evolution; Functional Magnetic Resonance Imaging; Funding; Future; Health; Hippocampus (Brain); Human; Image; Image Analysis; Imaging Techniques; Journals; Knowledge; Light; Longitudinal Studies; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methodology; Methods; Multivariate Analysis; National Institute of Mental Health; Neurodevelopmental Disorder; Neurosciences; Parietal; Pediatric Hospitals; Pediatric Research; Peer Review; Pennsylvania; Performance; Perfusion; Perfusion Weighted MRI; Phase; Philadelphia; Physiologic pulse; Physiological; Population; Positioning Attribute; Prefrontal Cortex; Process; Productivity; Property; Protocols documentation; Publications; Radioisotopes; Regional Perfusion; Relative (related person); Reproducibility; Research; Resolution; Resources; Rest; Safety; Short-Term Memory; Signal Transduction; Spin Labels; Statistical sensitivity; Structure; System; Technical Expertise; Techniques; Testing; Time; Tissues; Universities; Variant; abstracting; aged; angular gyrus; association cortex; base; bioimaging; blood flow measurement; blood oxygen level dependent; brain tissue; cognitive neuroscience; design; image registration; imaging modality; improved; in vivo; indexing; morphometry; neurogenetics; neuroimaging; pre-clinical; relating to nervous system; response

DESCRIPTION (provided by applicant): Project Summary/Abstract The theme of the proposed project is to develop a functional template or atlas of the developing brain based on quantitative cerebral blood flow (CBF) measurements using arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI). Parenchymal perfusion is an important physiologic parameter in the evaluation and management of brain disorders as well as a surrogate index of neural activity. Such information has been sparse in the pediatric population due to the safety concerns and technical difficulties associated with existing methods to measure perfusion that rely on radioisotopes and contrast agents. ASL perfusion MRI is ideally suited for pediatric perfusion imaging, because it is totally noninvasive and provides high image quality due to unique physiologic properties of a child brain. The capability for absolute CBF quantification is another desirable feature of ASL for longitudinal studies to follow neurodevelopmental changes. Through a pilot Human Brain Project funded by NIMH (R21- MH072576, PI: Wang), we have established the feasibility of pediatric perfusion MRI using ASL, and demonstrated the developmental trajectory of CBF in healthy children as well as perfusion aberrations in pre-clinical and clinical pediatric populations. The proposed R01 project represents a continued and systematic effort to address the functional development of a child brain utilizing ASL perfusion MRI. We will first establish the test-retest repeatability and determine the optimal ASL technique along with imaging parameters for constructing the pediatric perfusion template. The accuracy of ASL CBF measurement in children will be validated using global flow rate to the brain determined by phase contrast MRI technique. In the following 4 years, we will develop the normative developmental template of brain perfusion in healthy children aged 7-16 based on ASL perfusion measurements at baseline. In the last aim, we will characterize the quantitative CBF changes in response to a well-characterized cognitive paradigm - working memory tasks - using a concurrent ASL and BOLD (blood-oxygen-level- dependent) fMRI paradigm. Once developed, the pediatric perfusion template will not only shed light on the evolution of brain function with age, but will also provide a valuable resource and reference system for future developmental neuroscience studies as well as clinical studies on childhood brain disorders.

描述（由申请人提供）：项目摘要/摘要所提出的项目的主题是基于定量的大脑血流（CBF）测量，使用动脉旋转标记（ASL）灌注磁共振共振成像（MRI）来开发发展大脑的功能模板或地图集。 实质灌注是评估和管理脑疾病以及神经活动的替代指数的重要生理参数。 由于与现有方法相关的安全问题和技术困难，以衡量依赖放射性病和对比剂的灌注，因此小儿人口稀疏。 ASL灌注MRI非常适合小儿灌注成像，因为它完全无创，并且由于儿童大脑的独特生理特性而提供了高图像质量。 绝对CBF定量的能力是ASL的另一个理想特征，即纵向研究遵循神经发育变化。 通过NIMH（R21-MH072576，PI：Wang）资助的试验人类脑项目，我们已经建立了使用ASL使用ASL的小儿灌注MRI的可行性，并证明了健康儿童中CBF的发育轨迹以及术前和临床小儿灌注量的灌注差异。 拟议的R01项目代表了使用ASL灌注MRI来解决儿童大脑功能发展的持续和系统的努力。 我们将首先建立重复测试重复性，并确定最佳ASL技术以及用于构建小儿灌注模板的成像参数。 通过通过相比对比度MRI技术确定的全球流量，将验证儿童ASL CBF测量的准确性。 在接下来的4年中，我们将根据基线时的ASL灌注测量值开发7-16岁健康儿童的脑灌注的规范性发展模板。 在最后一个目标中，我们将使用并发的ASL和BOLD（血氧级依赖性）fMRI范式来表征定量CBF的变化，以响应良好的认知范式 - 工作记忆任务。 一旦开发，小儿灌注模板不仅会随着年龄的增长阐明大脑功能的演变，而且还将为未来的发育神经科学研究以及有关儿童脑疾病的临床研究提供宝贵的资源和参考系统。