Biostatistics Core

生物统计学核心

• 批准号: 8528458
• 负责人: Hulin Wu
• 金额: $ 12.71万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528458
• 关键词: B-Lymphocytes; Biometry; Biostatistics Core; Cell Cycle Kinetics; Cell Proliferation; Data; Data Analyses; Deuterium; Disease; Experimental Designs; Flow Cytometry; Health; Ice; Label; Manuscripts; Population; Preparation; Publications; Reporting; Research Design; Research Personnel; Services; Work; abstracting; data management; data modeling; design; experience; high throughput analysis; human subject; in vivo; mathematical model; member; programs; research study

Biostatistics and Data Management (BDM) Core of this program project will provide support and services for expenmental design, data management, data analysis and mathematical modeling for each of the proposed projects. We will also assist in drafting data analysis reports and preparing manuscripts for all proposed expehments and studies. Specific aims include: 1) Support study design, perform data analysis, prepare analysis reports, and assist in drafting abstracts and manuscripts for publication related to all studies in this program project; 2) Provide support for multi-parameter flow cytometry data analyses that include flow cytometry data gating to identify sub-populations and CFSE labeling data modeling/analysis to quantify cell proliferations; 3) Provide services of mathematical modeling and statistical analysis for the proposed deuterium in vivo labeling expehments to determine key parameters of cell proliferation and kinetics in vivo in human subjects; 4) Perform analysis of high throughput microarray data for the proposed projects; and 5) Provide centralized data management services to all projects and studies. In order to achieve these aims of the BDM Core, we have formed an experienced team consisting of biostatisticians, biomathematical modelers, and data managers with a variety of expertise in all required services. The BDM Core members will closely work with the project investigators in design of experiments, data analysis and preparation of analysis report and manuschpts.

该计划项目的生物统计学和数据管理（BDM）核心将为 每个提议的支出设计，数据管理，数据分析和数学建模 项目。我们还将协助起草数据分析报告并为所有提议的手稿准备 经验和研究。具体目的包括：1）支持研究设计，执行数据分析，准备 分析报告，并协助起草摘要和手稿，以进行与所有研究有关的出版 计划项目； 2）为包括流量的多参数流式细胞仪数据提供支持 细胞仪数据门控，以识别子群和CFSE标记数据建模/分析以量化细胞 增殖； 3）为拟议的数学建模和统计分析提供服务 体内标记氘式经验，以确定体内细胞增殖和动力学的关键参数 人类受试者； 4）对拟议项目的高吞吐量微阵列数据进行分析； 5） 为所有项目和研究提供集中的数据管理服务。为了实现这些目标 BDM核心，我们组成了一支经验丰富的团队，由生物统计学家，生物心理学组成 建模者和具有各种专业知识的数据经理在所有必需的服务中。 BDM核心成员 将与项目调查人员密切合作实验设计，数据分析和准备 分析报告和Manuschpts。