Biostatistics Core

生物统计学核心

• 批准号: 8528458
• 负责人: Hulin Wu
• 金额: $ 12.71万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528458
• 关键词: B-Lymphocytes; Biometry; Biostatistics Core; Cell Cycle Kinetics; Cell Proliferation; Data; Data Analyses; Deuterium; Disease; Experimental Designs; Flow Cytometry; Health; Ice; Label; Manuscripts; Population; Preparation; Publications; Reporting; Research Design; Research Personnel; Services; Work; abstracting; data management; data modeling; design; experience; high throughput analysis; human subject; in vivo; mathematical model; member; programs; research study

Biostatistics and Data Management (BDM) Core of this program project will provide support and services for expenmental design, data management, data analysis and mathematical modeling for each of the proposed projects. We will also assist in drafting data analysis reports and preparing manuscripts for all proposed expehments and studies. Specific aims include: 1) Support study design, perform data analysis, prepare analysis reports, and assist in drafting abstracts and manuscripts for publication related to all studies in this program project; 2) Provide support for multi-parameter flow cytometry data analyses that include flow cytometry data gating to identify sub-populations and CFSE labeling data modeling/analysis to quantify cell proliferations; 3) Provide services of mathematical modeling and statistical analysis for the proposed deuterium in vivo labeling expehments to determine key parameters of cell proliferation and kinetics in vivo in human subjects; 4) Perform analysis of high throughput microarray data for the proposed projects; and 5) Provide centralized data management services to all projects and studies. In order to achieve these aims of the BDM Core, we have formed an experienced team consisting of biostatisticians, biomathematical modelers, and data managers with a variety of expertise in all required services. The BDM Core members will closely work with the project investigators in design of experiments, data analysis and preparation of analysis report and manuschpts.

该计划项目的生物统计和数据管理（BDM）核心将为以下项目提供支持和服务： 每个提议的实验设计、数据管理、数据分析和数学建模 项目。我们还将协助起草数据分析报告并为所有提议准备手稿 实验和研究。具体目标包括： 1) 支持研究设计、进行数据分析、准备 分析报告，并协助起草与本研究相关的摘要和手稿以供出版 计划项目； 2) 为多参数流式细胞术数据分析提供支持，包括流式细胞术 用于识别亚群的细胞计数数据门控和用于量化细胞的 CFSE 标记数据建模/分析 扩散； 3）为拟定方案提供数学建模和统计分析服务 氘体内标记实验，以确定体内细胞增殖和动力学的关键参数 人类受试者； 4) 对拟议项目进行高通量微阵列数据分析；和 5) 为所有项目和研究提供集中数据管理服务。为了实现这些目标 BDM核心，我们组建了一支经验丰富的团队，由生物统计学家、生物数学家组成 在所有所需服务方面拥有各种专业知识的建模师和数据经理。 BDM核心成员 将与项目研究人员密切合作，进行实验设计、数据分析和准备 分析报告和手稿。