Michigan Regional Comprehensive Metabolomics Resource Core (MRC2)

密歇根区域综合代谢组学资源核心 (MRC2)

• 批准号: 8426430
• 负责人: CHARLES F BURANT
• 金额: $ 266.68万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-04 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8426430
• 关键词: Access to Information; Area; Award; Basic Science; Bioinformatics; Biological; Biomedical Research; Blood; Businesses; Cancer Center Support Grant; Cells; Clinical; Clinical Research; Clinical Research Protocols; Clinical Sciences; Collaborations; Communities; Complex; Consultations; Core Facility; Coupled; Data; Data Analyses; Databases; Detection; Diabetes Mellitus; Disease; Educational workshop; Evaluation; Faculty; Gas-Liquid Chromatography; Grant; Growth; Health; Housing; Imagery; Information Technology; Institutes; Knowledge; Laboratories; Liquid substance; Mass Spectrum Analysis; Measures; Medicine; Metabolism; Methodology; Michigan; Mining; National Center for Integrative Biomedical Informatics; Nuclear Magnetic Resonance; Obesity; Online Systems; Output; Process; Protocols documentation; Research; Research Infrastructure; Research Personnel; Resources; Schools; Services; Students; Technology; Tissues; Training; Translational Research; United States; Universities; Work; base; biological systems; computerized data processing; data integration; design; improved; insight; medical schools; meetings; metabolomics; operation; outreach; pre-clinical research; prevent; programs; research study; small molecule; statistics; symposium; tool

DESCRIPTION (provided by applicant): The proposed Michigan Regional Comprehensive Metabolomics Resource Core (MRCMRC or MRC2) is a fully integrated program that will provide researchers nation-wide with the expertise and infrastructure to determine the levels of known and unknown metabolites in cells, tissues and biological fluids. In addition, the MRC will provide opportunities for training in the technology of metabolomic analysis, statistical analysis and bioinformatic evaluation of metabolite data as well as approaches to Incorporation of metabolomics into basic, preclinical, translational and clinical research. Incorporated into this service component will be a robust research component directed towards improving the breadth of metabolite detection, the quality and efficiency of metabolomic analysis and importantly, tools to turn spectral data into knowledge to for the researcher The MRC2 will contain an Administrative Core to oversee and integrate operations; an Analytical Core to help design experiments for directed quantitative measure of metabolites or high-throughput evaluation of large numbers of known and unknown metabolites; a Data and Information Technology Core which will perform primary data processing or re-mining of archival data and will serve as a data repository; a Statistics and Bioinformatics Core which will assist researchers in the statistical evaluation of metabolomic data and integration with other 'omics or phenotypic data; and a Promotion and Outreach Core which will organize and provide seminars, symposia, workshops and web-based videos to increase the lay and research communities knowledge and use of metabolomic data. PUBLIC HEALTH RELEVANCE: The RCMRC grant is directed towards providing increasing the technology to measure small molecules (metabolites) found in the body. These metabolites are the building blocks of all cells and participate in all body processes. By providing researchers with ways to measure the metabolites accurately from cells and tissues and in the blood, new insights into the ways In which changes in metabolism can contribute to diseases, such as diabetes and caner will be found. With this knowledge, new ways to prevent and treat a variety of diseases may be possible.

描述（由申请人提供）：拟议的密歇根州区域综合代谢组学资源核心（MRCMRC或MRC2）是一个完全集成的计划，将为全国范围内的研究人员提供专业知识和基础设施，以确定细胞，组织和生物体流体中已知和未知代谢物的水平。此外，MRC将为代谢组分析，统计分析和代谢物数据的生物信息学评估以及将代谢组学纳入基本，临床前，转化和临床研究的方法提供机会。 纳入本服务组件将是一个可靠的研究组件，用于改善代谢物检测的广度，代谢组学分析的质量和效率，重要的是，将光谱数据转换为知识的工具将为研究人员提供MRC2的知识，其中MRC2将包含一个管理和集成操作的行政核心；一种分析核心，可帮助设计实验，以定量定量代谢物或对大量已知和未知代谢产物的高通量评估；数据和信息技术核心将执行档案数据的主要数据处理或重新挖掘并将作为数据存储库；统计和生物信息学核心，将帮助研究人员对代谢组数据进行统计评估，并与其他“ OMICS”或“表型数据”集成；以及将组织和提供研讨会，研讨会，研讨会和基于Web的视频的促销和外展核心，以增加外行和研究社区的知识和代谢性数据的使用。 公共卫生相关性：RCMRC赠款旨在提供增加体内发现的小分子（代谢物）的技术。这些代谢物是所有细胞的基础，并参与所有身体过程。通过为研究人员提供从细胞和组织和血液中准确测量代谢产物的方法，对代谢变化的方式可以导致疾病（例如糖尿病和罐头）的新见解。有了这些知识，可能可以进行预防和治疗各种疾病的新方法。