Inflammation and T Lymphocyte Immunoregulation

炎症与T淋巴细胞免疫调节

• 批准号: 8268409
• 负责人: Ann B Hill
• 金额: $ 30.21万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8268409
• 关键词: Inflammation; T-Lymphocyte; immunoregulation; Inflammation; T-Lymphocyte; immunoregulation

Form Approved Through 11/30/2010 0MB No. 0925-0001 Department of Health and Human Public Health Services 5 2006 PI: PARKER, DAVID C Council: 05/2009 12147749 Application 1 T32 AI078903-01 A1 \er length restrictions indicated. Dual: 1. TITLE OF PROJECT (Do not exceed 81 characters, including spaces and pun^ IRG: ZAI1 SRC(99) Received: 09/25/2008 Inflammation and T Lymphocyte Immunoregulation 2. RESPONSE TO SPECIFIC REQUEST FOR APPLICATIONS OR PROGRAM ANNOUNCEMENT OR SOLICITATION D NO | YES (If "Yes," state number and title) Number: PA-08-226 Title: Institutional Ruth L. Kirschstein NRSA 3. PROGRAM DIRECTOR/PRINCIPAL INVESTIGATOR New Investigator No DYOS 3a. NAME (Last, first, middle) 3b. DEGREE(S) 3h. eRA Commons User Name Parker, David C. PhD PARKERD 3c. POSITION TITLE 3d. MAILING ADDRESS (Street, city, state, zip code) Professor 3181 SW Sam Jackson Park Road 3e. DEPARTMENT, SERVICE, LABORATORY. OR EQUIVALENT Portland, Oregon 97239 Molecuir Microbiology & Immunolog 3f. MAJOR SUBDIVISION School of Medicine 3g. TELEPHONE AND FAX (Area code, number and extension) E-MAIL ADDRESS: TEL: [phone] FAX: [phone] [e-mail] 4. HUMAN SUBJECTS RESEARCH 4a. Research Exempt If "Yes," Exemption No. D No S Yes S No D Yes 4b. Federal-Wide Assurance No. 4c. Clinical Trial 4d. NIH-defined Phase III Clinical Trial FWA00000161 S No n Yes S No n Yes 5. VERTEBRATE ANIMALS Q No |3 Yes 5a. Animal Welfare Assurance No. A3304-01 6. DATES OF PROPOSED PERIOD OF COSTS REQUESTED FOR INITIAL 8. COSTS REQUESTED FOR PROPOSED SUPPORT (month, day. year-MM/DD/YY) BUDGET PERIOD PERIOD OF SUPPORT From Througli 7a. Direct Costs ($) 7b. Total Costs ($) 8a. Direct Costs ($) 8b. Total Costs ($) 07/01/2009 06/30/2014 $359,555 $379,020 $1,833,706 $1,931,031 9. APPLICANT ORGANIZATION 10. TYPE OF ORGANIZATION Name Oregon Health & Science University Public: -^ n Federal ^ State Q Local Address 3181 SW Sam Jackson Park Road Private: -^ d) Private Nonprofit Portland, Oregon 97239 For-profit: -> L] General [j Small Business I I Woman-owned O Socially and Economically Disadvantaged 11. ENTITY IDENTIFICATION NUMBER 1931176109A1 DUNS NO. 09-699-7515 Cong. District 1 12. ADMINISTRATIVE OFFICIAL TO BE NOTIFIED IF AWARD IS MADE 13. OFFICIAL SIGNING FOR APPLICANT ORGANIZATION Name Valerie Mansur Name Deborah Golden-Eppelein Title Assistant Manager Grants & Contracts Title Director, Grants & Contracts Address 3181 SW Sam Jackson Park Road Address 3181 SW Sam Jackson Park Road Portland, Oregon 97239 '^ Portland, Oregon 97239 Tel: [phone] FAX: [phone] Tel: [phone] FAX: [phone] E-Mail: [e-mail] E-Mail: [e-mail] 14. APPLICANT ORGANIZATION CERTIFICATION AND ACCEPTANCE: I certify that SIGNATURE OF OFFICIAL NAMED IN 13. DATE the statements herein are true, complete and accurate to the best of my knowledge, and (In ink. "Per" signature not acceptable.) accept the obligation to comply with Public Health Services terms and conditions If a grant sistatewmarednetds aosr calariemssultmoafythsiusbajepcptlimcaetioton.crIimaminal,wcaivreil,tohrataadnmyinfaislstrea,tivfiectiptieonuasl,tioers.fraudulent AJ^J^ ¿y//^^' PHS 398 (Rev. 11/07) Face Page Form Page 1 Program Director/Principal Investigator (Last, First, Middle): Parker, Davlci C. Because of its interdisciplinary nature, its rapid acquisition and development of new technologies, and its direct relevance to human disease, immunology is an excellent vehicle for training in basic biomedical research. Exciting new findings and the enormous potential for powerful applications to human disease continue to attract many of the best students to immunology. Increasingly, it is now possible to translate our knowledge of immunity into manipulations of T cells and inflammation in clinical applications, and many of the next generation of immunologists will find rewarding careers in translational research. We believe that the best foundation for translational research is uncompromisingly rigorous traditional PhD training, with a solid basic science basis. Scientists trained in this way have been responsible for past gains in knowledge that are now being translated into clinical applications, and will continue to play this role in the future. Nevertheless, we recognize that traditional PhD training can leave both a knowledge gap and a misunderstanding of the culture of clinical medicine that many scientists find difficult to overcome. These problems limit entry of some of the best PhD scientists into translational research. Our program incorporates several innovative features designed to help our trainees bridge this gap. The twenty-one mentors in our program lead an interactive, interdepartmental reseach community that covers the full range of biomedical science from genomics and proteomics, intracellular signaling pathways, cell biology, microbiology, and cellular immunology to clinical studies and trials, all centered around regulation of inflammation and T lymphocyte biology. In our program, students and postdoctoral fellows studying areas as distinct as vaccine design, immune evasion by viruses or bacteria, tumor immunology, immunopathology, transplantation, and autoimmunity benefit from learning about methods of investigation and advances in the other areas as part of this interactive research community. The goal of our program is to recruit talented and motivated students and post-doctoral fellows, provide them with a firm foundation in the latest techniques and concepts in biomedical research, expose them to translational research opportunities, and foster precision, curiosity, daring, imagination, communication, and cooperation to give them the tools they need to direct independent research programs and train the next generation of biomedical scientists. Relevance: Many advances in treatment and prevention of human diseases depend upon advances in understanding how the body works and interacts with the environment. This program is designed to train effective biomedical scientists who will become leaders in making new discoveries and will remain alert to the Dossibilities of usina new knowledge to improve human health

通过2010年11月30日批准的表格0MB编号0925-0001 卫生与人类 公共卫生服务5 2006 PI：帕克，大卫C委员会：05/2009 12147749应用程序1 T32 AI078903-01 A1 \ er长度限制表示。双重的： 1。项目的标题（不超过81个字符，包括空格和双关语：Zai1 Src（99）收到：09/25/2008 炎症和T淋巴细胞免疫调节 2。对申请或计划公告或征求的特定请求的响应d no |是的 （如果是“是”，状态号和标题） 编号：PA-08-226标题：机构Ruth L. Kirschstein NRSA 3.计划主管/首席研究员新调查员无Dyos 3a。名称（最后，第一个，中间）3b。学位3H。 ERA CONSONS用户名 帕克，大卫·C·帕克德 3C。职位标题3D。邮寄地址（街，城市，州，邮政编码） 3181教授SW Sam Jackson Park Road 3e。服务部，实验室服务部。或等效的波特兰，俄勒冈州97239 分子微生物学和免疫学 3f。主要细分 医学院 3G。电话和传真（区域代码，编号和扩展）电子邮件地址： 电话：503-494-1498传真：503-494-6862 [e-mail] 4。人类受试者研究4a。研究豁免，如果是“是”，豁免号。 d否s是s否D是 4b。联邦范围的保证第4C号。临床试验4D。 NIH定义的III期临床试验 fwa00000161 s no n是s n n n y是 5。脊椎动物Q否| 3是5a。动物福利保证号A3304-01 6。提议的最初8的拟议费用日期。要求提议的费用 支持（月，日期。年度/dd/yy）预算期间的支持期 从透过7a。直接费用（$）7b。总费用（$）8a。直接费用（$）8B。总费用（$） 07/01/2009 06/30/2014 $ 359,555 $ 379,020 $ 1,833,706 $ 1,931,031 9。申请人组织10。组织类型 名称俄勒冈州健康与科学大学公众： - ^ n联邦 ^州Q本地 地址3181 SW SAM JACKSON PARK ROAD私人： - ^ D）私人非营利组织 俄勒冈州波特兰市97239营利性： - > l]一般[J小企业 我在社会和经济上拥有的妇女拥有 11。实体标识号 1931176109a1 邓斯09-699-7515 CON。区1 12。如果获得裁决13，则将通知行政官员。 名称Valerie Mansur名称Deborah Golden-Eppelein 标题助理经理赠款和合同标题总监，赠款和合同 地址3181 SW SAM JACKSON PARK ROAD地址3181 SW SAM JACKSON PARK ROAD 俄勒冈州波特兰市97239'^波特兰，俄勒冈州97239 电话：503-494-7784传真：503-494-7787电话：503-494-7784传真：503-494-7787 电子邮件：[e-mail]电子邮件：[e-mail] 14.申请人组织认证和接受：我证明了13日命名的官员的签名。 据我所知，这里的陈述是真实的，完整而准确的，并且（用墨水。“ per”签名不可接受。） 如果赠款，接受遵守公共卫生服务条款和条件的义务 sistatewmarednetds aosr calariemssultmoafythsusbajepcptlimcaetioton.criimamineal，wcaivreil，tohrataadnmyinfaislStrea，tivfiectiptiipipiptiieonuasl，tioers.tioers.fraudulen aj^j^j^j^j^j^j^y y/y//y//^^'y//^^' PHS 398（Rev. 11/07）面部页面形式页面1 项目总监/首席研究员（最后，第一，中间）：帕克，达维尔奇C. 由于其跨学科的性质，其新技术的快速获取和发展及其 与人类疾病的直接相关性，免疫学是培训基本生物医学的绝佳工具 研究。令人兴奋的新发现以及强大应用人类疾病的巨大潜力 继续吸引许多最好的学生进行免疫学。越来越多的人现在可以翻译我们 在临床应用中对T细胞操纵和感染的免疫知识以及许多 下一代免疫学家将在转化研究中找到有益的职业。我们相信 转化研究的最佳基础是毫不妥协的传统博士培训，并有一个 坚实的基础科学基础。以这种方式培训的科学家已经造成了过去的成就 现在正在转化为临床应用，并将在将来继续扮演这一角色。 尽管如此，我们认识到传统的博士学位培训可以留下知识差距和 许多科学家难以克服的临床医学文化的误解。这些 问题限制了一些最好的博士学位科学家进入翻译研究。我们的计划合并 一些创新的功能旨在帮助我们的培训桥梁这一差距。我们的二十一名导师 计划领导一个互动，部门间的研究社区，该社区涵盖了全部生物医学的范围 来自基因组学和蛋白质组学的科学，细胞内信号通路，细胞生物学，微生物学和 细胞免疫学对临床研究和试验，均围绕调节炎症和T 淋巴细胞生物学。在我们的计划中，学生和博士后研究员学习与疫苗一样不同的区域 设计，病毒或细菌免疫驱虫，肿瘤免疫学，免疫病理学，移植和 自身免疫性从学习其他领域的投资方法和进步方法中受益 这个互动研究社区。我们计划的目标是招募有才华和成熟的学生 和博士后研究员，为他们提供最新技术和概念的坚定基础 生物医学研究，使他们获得翻译的研究机会，并提高精度，好奇心， 大胆，想象力，沟通和合作，为他们提供直接独立所需的工具 研究计划并培训下一代生物医学科学家。 相关性：治疗和预防人类疾病的许多进展取决于进步 了解身体的工作原理并与环境互动。该程序旨在训练 有效的生物医学科学家将成为新发现的领导者，并将保持警惕 USINA的新知识的杂志以改善人类健康