Inflammation and T Lymphocyte Immunoregulation

炎症与T淋巴细胞免疫调节

• 批准号: 8268409
• 负责人: Ann B Hill
• 金额: $ 30.21万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8268409
• 关键词: Inflammation; T-Lymphocyte; immunoregulation

Form Approved Through 11/30/2010 0MB No. 0925-0001 Department of Health and Human Public Health Services 5 2006 PI: PARKER, DAVID C Council: 05/2009 12147749 Application 1 T32 AI078903-01 A1 \er length restrictions indicated. Dual: 1. TITLE OF PROJECT (Do not exceed 81 characters, including spaces and pun^ IRG: ZAI1 SRC(99) Received: 09/25/2008 Inflammation and T Lymphocyte Immunoregulation 2. RESPONSE TO SPECIFIC REQUEST FOR APPLICATIONS OR PROGRAM ANNOUNCEMENT OR SOLICITATION D NO | YES (If "Yes," state number and title) Number: PA-08-226 Title: Institutional Ruth L. Kirschstein NRSA 3. PROGRAM DIRECTOR/PRINCIPAL INVESTIGATOR New Investigator No DYOS 3a. NAME (Last, first, middle) 3b. DEGREE(S) 3h. eRA Commons User Name Parker, David C. PhD PARKERD 3c. POSITION TITLE 3d. MAILING ADDRESS (Street, city, state, zip code) Professor 3181 SW Sam Jackson Park Road 3e. DEPARTMENT, SERVICE, LABORATORY. OR EQUIVALENT Portland, Oregon 97239 Molecuir Microbiology & Immunolog 3f. MAJOR SUBDIVISION School of Medicine 3g. TELEPHONE AND FAX (Area code, number and extension) E-MAIL ADDRESS: TEL: [phone] FAX: [phone] [e-mail] 4. HUMAN SUBJECTS RESEARCH 4a. Research Exempt If "Yes," Exemption No. D No S Yes S No D Yes 4b. Federal-Wide Assurance No. 4c. Clinical Trial 4d. NIH-defined Phase III Clinical Trial FWA00000161 S No n Yes S No n Yes 5. VERTEBRATE ANIMALS Q No |3 Yes 5a. Animal Welfare Assurance No. A3304-01 6. DATES OF PROPOSED PERIOD OF COSTS REQUESTED FOR INITIAL 8. COSTS REQUESTED FOR PROPOSED SUPPORT (month, day. year-MM/DD/YY) BUDGET PERIOD PERIOD OF SUPPORT From Througli 7a. Direct Costs ($) 7b. Total Costs ($) 8a. Direct Costs ($) 8b. Total Costs ($) 07/01/2009 06/30/2014 $359,555 $379,020 $1,833,706 $1,931,031 9. APPLICANT ORGANIZATION 10. TYPE OF ORGANIZATION Name Oregon Health & Science University Public: -^ n Federal ^ State Q Local Address 3181 SW Sam Jackson Park Road Private: -^ d) Private Nonprofit Portland, Oregon 97239 For-profit: -> L] General [j Small Business I I Woman-owned O Socially and Economically Disadvantaged 11. ENTITY IDENTIFICATION NUMBER 1931176109A1 DUNS NO. 09-699-7515 Cong. District 1 12. ADMINISTRATIVE OFFICIAL TO BE NOTIFIED IF AWARD IS MADE 13. OFFICIAL SIGNING FOR APPLICANT ORGANIZATION Name Valerie Mansur Name Deborah Golden-Eppelein Title Assistant Manager Grants & Contracts Title Director, Grants & Contracts Address 3181 SW Sam Jackson Park Road Address 3181 SW Sam Jackson Park Road Portland, Oregon 97239 '^ Portland, Oregon 97239 Tel: [phone] FAX: [phone] Tel: [phone] FAX: [phone] E-Mail: [e-mail] E-Mail: [e-mail] 14. APPLICANT ORGANIZATION CERTIFICATION AND ACCEPTANCE: I certify that SIGNATURE OF OFFICIAL NAMED IN 13. DATE the statements herein are true, complete and accurate to the best of my knowledge, and (In ink. "Per" signature not acceptable.) accept the obligation to comply with Public Health Services terms and conditions If a grant sistatewmarednetds aosr calariemssultmoafythsiusbajepcptlimcaetioton.crIimaminal,wcaivreil,tohrataadnmyinfaislstrea,tivfiectiptieonuasl,tioers.fraudulent AJ^J^ ¿y//^^' PHS 398 (Rev. 11/07) Face Page Form Page 1 Program Director/Principal Investigator (Last, First, Middle): Parker, Davlci C. Because of its interdisciplinary nature, its rapid acquisition and development of new technologies, and its direct relevance to human disease, immunology is an excellent vehicle for training in basic biomedical research. Exciting new findings and the enormous potential for powerful applications to human disease continue to attract many of the best students to immunology. Increasingly, it is now possible to translate our knowledge of immunity into manipulations of T cells and inflammation in clinical applications, and many of the next generation of immunologists will find rewarding careers in translational research. We believe that the best foundation for translational research is uncompromisingly rigorous traditional PhD training, with a solid basic science basis. Scientists trained in this way have been responsible for past gains in knowledge that are now being translated into clinical applications, and will continue to play this role in the future. Nevertheless, we recognize that traditional PhD training can leave both a knowledge gap and a misunderstanding of the culture of clinical medicine that many scientists find difficult to overcome. These problems limit entry of some of the best PhD scientists into translational research. Our program incorporates several innovative features designed to help our trainees bridge this gap. The twenty-one mentors in our program lead an interactive, interdepartmental reseach community that covers the full range of biomedical science from genomics and proteomics, intracellular signaling pathways, cell biology, microbiology, and cellular immunology to clinical studies and trials, all centered around regulation of inflammation and T lymphocyte biology. In our program, students and postdoctoral fellows studying areas as distinct as vaccine design, immune evasion by viruses or bacteria, tumor immunology, immunopathology, transplantation, and autoimmunity benefit from learning about methods of investigation and advances in the other areas as part of this interactive research community. The goal of our program is to recruit talented and motivated students and post-doctoral fellows, provide them with a firm foundation in the latest techniques and concepts in biomedical research, expose them to translational research opportunities, and foster precision, curiosity, daring, imagination, communication, and cooperation to give them the tools they need to direct independent research programs and train the next generation of biomedical scientists. Relevance: Many advances in treatment and prevention of human diseases depend upon advances in understanding how the body works and interacts with the environment. This program is designed to train effective biomedical scientists who will become leaders in making new discoveries and will remain alert to the Dossibilities of usina new knowledge to improve human health

表格于 2010 年 11 月 30 日批准 0MB 编号 0925-0001 健康与人类部 公共卫生服务 5 2006 PI：PARKER、DAVID C 理事会：05/2009 12147749 应用 1 T32 AI078903-01 A1 \er 表示长度限制。 1. 项目标题（不要超过 81 个字符，包括空格和双关语^ IRG: ZAI1 SRC(99) 收稿日期：09/25/2008 炎症与淋巴细胞免疫调节 2. 对具体申请请求、计划公告或征集的回应 D 否 | 是 （如果“是”，请注明编号和标题） 编号：PA-08-226 标题：机构 Ruth L. Kirschstein NRSA 3. 项目总监/首席研究员 新研究员 否 DYOS 3a. 姓名（姓氏、名字、中间名） 3b. eRA 共享用户名 Parker, David C. 博士 PAKERD 3c. 职位名称 3d. 邮寄地址（街道、城市、州、邮政编码） 教授 3181 SW Sam Jackson Park Road 3e. 服​​务部门、实验室或同等部门 俄勒冈州波特兰 97239 分子微生物学和免疫学 3f. 主要细分 医学院 3g. 电话和传真（区号、号码和分机号） 电子邮件地址： 电话：503-494-1498 传真：503-494-6862 [e-mail] 4. 人类受试者研究 4a. 研究豁免 如果“是”，则豁免编号 D 否 S 是 S 否 D 是 4b. 联邦范围保证 4c 号临床试验。 FWA00000161 S 否 n 是 S 否 n 是 5. 脊椎动物 Q 否 |3 是 5a 动物福利保证号 6. 拟议初始费用期间的日期 8. 拟议费用要求 支持（月、日、年-MM/DD/YY） 预算周期 支持周期 来自 Throughli 7a. 直接成本 ($) 7b. 总成本 ($) 8a. 总成本 ($) 2009年7月1日 2014年6月30日 $359,555 $379,020 $1,833,706 $1,931,031 9. 申请组织 10. 组织类型 名称 俄勒冈健康与科学大学 公立：-^ n 联邦 ^ 州 Q 地方 地址 3181 SW Sam Jackson Park Road 私人：-^ d) 私人非营利组织 Portland, Oregon 97239 营利性：-> L] 一般 [j 小型企业 I I 女性拥有 O 社会和经济弱势群体 11. 实体识别号码 1931176109A1 邓白氏编号 09-699-7515 康区 1 12. 如果作出裁决，需通知行政官员 13. 申请组织的正式签字 瓦莱丽·曼苏尔（Valerie Mansur） 姓名 黛博拉·戈尔登-埃佩林（Deborah Golden-Eppelein） 职称 补助金与合同助理经理 职称 补助金与合同总监 地址 萨姆杰克逊公园路西南 3181 号 地址 萨姆杰克逊公园路西南 3181 号 俄勒冈州波特兰 97239 '^ 俄勒冈州波特兰 97239 电话：503-494-7784 传真：503-494-7787 电话：503-494-7784 传真：503-494-7787 电子邮件：[e-mail] 电子邮件：[e-mail] 14. 申请组织的认证和接受：我证明 13 中指定的官员签名。 日期 据我所知，本文中的陈述真实、完整和准确，并且（用墨水书写。“Per”签名不可接受。） 接受遵守公共卫生服务条款和条件的义务 如果拨款 sistatewmarednetds aosr calariemssultmoafythsiusbajepcptlimcaetioton.crIimaminal、wcaivreil、tohrataadnmyinfaislstrea、tivfiectiptieonuasl、tioers.fraudulent AJ^J^ ¿是//^^' PHS 398（修订版 11/07）正面页面表格第 1 页 项目总监/首席研究员（最后、第一、中间）：Parker, Davlci C. 由于其跨学科性质、新技术的快速获取和发展以及其 免疫学与人类疾病直接相关，是基础生物医学培训的绝佳工具 令人兴奋的新发现以及在人类疾病方面的强大应用的巨大潜力。 继续吸引许多最优秀的学生学习免疫学，现在越来越有可能将我们的成果转化为免疫学。 临床应用中 T 细胞操作和炎症的免疫知识，以及许多 我们相信，下一代免疫学家将在转化研究中找到有价值的职业。 转化研究的最佳基础是毫不妥协的严格传统博士培训， 经过这种方式训练的科学家们对过去的知识进步负有责任。 目前正在转化为临床应用，并将在未来继续发挥这一作用。 尽管如此，我们认识到传统的博士培训可能会留下知识差距和 许多科学家发现很难克服对临床医学文化的误解。 问题限制了一些最优秀的博士科学家进入转化研究。 我们的二十一位导师旨在帮助我们的学员弥补这一差距。 该计划领导一个互动的、跨部门的研究社区，涵盖生物医学的各个领域 来自基因组学和蛋白质组学、细胞内信号传导途径、细胞生物学、微生物学和 细胞免疫学到临床研究和试验，全部围绕炎症和 T 细胞的调节 在我们的项目中，学生和博士后研究员研究的领域与疫苗一样不同。 设计、病毒或细菌的免疫逃避、肿瘤免疫学、免疫病理学、移植和 自身免疫受益于了解研究方法和其他领域的进展作为一部分 这个互动研究社区的目标是招募有才华和积极性的学生。 和博士后研究员，为他们提供最新技术和概念的坚实基础 生物医学研究，让他们有转化研究的机会，培养精确性、好奇心、 大胆、想象力、沟通和合作，为他们提供指导独立所需的工具 研究计划并培训下一代生物医学科学家。 相关性：人类疾病治疗和预防方面的许多进步取决于以下方面的进步： 了解身体如何运作以及如何与环境相互作用。该计划旨在进行培训。 高效的生物医学科学家，他们将成为新发现的领导者，并保持警惕 利用新知识改善人类健康的可能性