Mechanical System for Low Force Fatigue Tissue Testing

用于低力疲劳组织测试的机械系统

• 批准号: 7792902
• 负责人: DAWN M ELLIOTT
• 金额: $ 13.24万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-13 至 2011-04-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7792902
• 关键词: American; Area; Arts; Bathing; Biocompatible Materials; Biological; Biological Preservation; Biomechanics; Cartilage; Cells; Communities; Computer software; Economics; Environment; Equipment; Fatigue; Frequencies; Funding; Health Sciences; Human Resources; Implant; Intervertebral disc structure; Ligaments; Liquid substance; Massachusetts; Measures; Mechanics; Modality; Muscle; Musculoskeletal; Musculoskeletal Diseases; New York; Noise; Occupations; Pennsylvania; Philadelphia; Positioning Attribute; Pre-Clinical Model; Property; Radial; Recovery; Research; Research Personnel; Resources; Sales; Services; Site; Speed; Structure; System; Technology; Temperature; Tendon structure; Testing; Tissue Engineering; Tissue Sample; Tissue Therapy; Tissues; United States National Institutes of Health; Universities; bone; clinical application; functional outcomes; grasp; injury and repair; instrument; instrumentation; medical schools; meetings; programs; relating to nervous system; scaffold; soft tissue; systems research; viscoelasticity

DESCRIPTION (provided by applicant): This instrumentation proposal is for the ElectroPuls E3000 Electrodynamic Test System (Instron Corp, Norwood, MA, USA). The ElectroPulse E3000 is a state-of-the art research system for fatigue testing. The test speed range from 1mm/min to 1.7m/second distinguishes the ElectroPuls system other available testing equipment. This feature will enable testing a wide range of biomaterials. The E3000 utilizes an all electric technology instead of hydraulics, using less energy, making less noise, thereby providing a clean "green" lab environment. Key system items are the control system, dynamic load cells, temperature controlled fluid bath, submersible grips, high load fatigue-rated grips, as well as testing and analysis software. This instrument will be located in and managed by the Structure-Function Biomechanics Core of the Penn Center for Musculoskeletal Disorders. This Core has been a critical resource facility for a large number of NIH- funded and non-NIH funded investigators at the University of Pennsylvania. The proposed system will greatly enhance the capabilities of the the Structure-Function Biomechanics Core. A primary objective of the research conducted by the Core is to measure the mechanical function of musculoskeletal tissues. In particular, mechanical properties of bone, cartilage, tendons, ligaments, intervertebral disc, muscle, and neural soft tissue samples are evaluated, and the effect on mechanical function of injury, repair, or biological treatment modalities is tested. Additionally, mechanical properties of tissue engineered constructs, biological scaffolds, and synthetic implants are measured. Low speed loading alone is not sufficient to determine the properties or evaluate functional outcomes of therapies. Higher strain rate and fatigue tests are needed to understand how these tissues and therapies will perform in clinical applications. As the musculoskeletal research community becomes more translational in its strategies, the mechanical function of the targeted tissue and musculoskeletal preclinical models must move toward physiologically relevant studies of fatigue and dynamic viscoelasticity. The loads and speeds provided by the ElectroPuls are essential for fatigues studies and dynamic frequency sweep viscoelastic testing of musculoskeletal tissues. The ElectroPuls meets a unique set of specifications not present in the existing mechanical testing equipment within the Penn Center for Musculoskeletal Disorders or within a 200 mile radius of the University of Pennsylvania. The American Recovery and Reinvestment Act of 2009: The University of Pennsylvania School of Medicine contributes substantially to the local economy. The School of Medicine contributed 37,000 jobs and $5.4 billion in regional economic activity in 2008. The current proposal will impact the research program of each user to preserve or create jobs within the greater Philadelphia area and advance science and health across the nation. Further, it will create or preserve jobs at the company associated with this instrument purchase. Instron operates manufacturing sites in Pennsylvania, New York and Massachusetts. Jointly, these three sites employ 136 manufacturing positions and 160 service personnel who will immediately benefit from the sale of an ElectroPuls system by the preservation and/or creation of jobs.

描述（由申请人提供）：该仪器提案适用于 ElectroPuls E3000 电动测试系统（Instron Corp，诺伍德，马萨诸塞州，美国）。 ElectroPulse E3000 是最先进的疲劳测试研究系统。 ElectroPuls 系统的测试速度范围为 1mm/min 至 1.7m/s，有别于其他可用的测试设备。此功能将使测试各种生物材料成为可能。 E3000采用全电动技术代替液压技术，能耗更低，噪音更低，从而提供干净的“绿色”实验室环境。关键系统项目包括控制系统、动态称重传感器、温控液体浴、潜水夹具、高负载疲劳额定夹具以及测试和分析软件。该仪器将位于宾夕法尼亚大学肌肉骨骼疾病中心的结构功能生物力学核心并由其管理。该核心一直是宾夕法尼亚大学大量 NIH 资助和非 NIH 资助的研究人员的重要资源设施。所提出的系统将大大增强结构功能生物力学核心的能力。 Core 进行的研究的主要目的是测量肌肉骨骼组织的机械功能。特别是评估骨骼、软骨、肌腱、韧带、椎间盘、肌肉和神经软组织样品的机械性能，并测试损伤、修复或生物治疗方式对机械功能的影响。此外，还测量了组织工程结构、生物支架和合成植入物的机械性能。仅低速加载不足以确定治疗的特性或评估功能结果。需要更高的应变率和疲劳测试来了解这些组织和疗法在临床应用中的表现。随着肌肉骨骼研究界在其策略上变得更加转化，目标组织的机械功能和肌肉骨骼临床前模型必须转向疲劳和动态粘弹性的生理相关研究。 ElectroPuls 提供的负载和速度对于肌肉骨骼组织的疲劳研究和动态扫频粘弹性测试至关重要。 ElectroPuls 符合宾夕法尼亚州肌肉骨骼疾病中心或宾夕法尼亚大学 200 英里半径范围内现有机械测试设备所不具备的一组独特规格。 2009 年美国复苏和再投资法案：宾夕法尼亚大学医学院为当地经济做出了重大贡献。 2008 年，医学院创造了 37,000 个就业岗位，为地区经济活动贡献了 54 亿美元。当前的提案将影响每个用户的研究计划，以在大费城地区保留或创造就业机会，并推动全国的科学和健康发展。此外，它将为与此次仪器购买相关的公司创造或保留就业机会。英斯特朗在宾夕法尼亚州、纽约州和马萨诸塞州设有生产基地。这三个工厂总共雇用了 136 个制造职位和 160 名服务人员，他们将通过保留和/或创造就业机会立即从 ElectroPuls 系统的销售中受益。