PROCESSING BASIC SOCIAL REWARDS

处理基本社会奖励

基本信息

批准号：
8483047
负责人：
RICHARD A ANDERSEN
金额：
$ 47.53万
依托单位：
CALIFORNIA INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-26 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8483047
关键词：
Address Age Amygdaloid structure Anterior Area Autistic Disorder Behavior Brain Brain region Categories Cell Nucleus Cells Code Data Decision Making Diagnosis Disease Electrophysiology (science)Emotional Empathy Epilepsy Face Foundations Functional Magnetic Resonance Imaging Functional disorder Gender Human Individual Differences Intelligence Investigation Juice Macaca mulatta Measures Membrane Potentials Mental disorders Monkeys Neurobiology Neurons Neurosciences Outcome Patients Performance Persons Population Prefrontal Cortex Process Property Recruitment Activity Research Resolution Rewards Sample Size Signal Transduction Smiling Social Interaction Social Values Staging Stimulus System Techniques Time Work base computerized data processing drinking emotional stimulus experience frontal lobe hedonic relating to nervous system research study social trait

项目摘要

This Project investigates the basic computations at work in making simple social decisions, and contrasts them with simple non-social decisions (e.g., ones based on the value of juice or money, rather than the value of other people). It sets the stage for all the others in investigating how social reward is represented and compares to nonsocial reward. An example of a non-social decision is choosing what to drink by pushing one of several buttons on a soda dispensing machine, an example of a social decision is choosing what person to call to go on a date. Here we address these questions: Are there regions in the amygdala and prefrontal cortex that encode stimulus values at the time of choice, and experienced (hedonic) values at the time of outcome, in the social domain (seeing smiling or beautiful faces), as they do in the nonsocial case (getting juice when thirsty)? Are there neurons specialized for valuation of social stimuli, or do the same cells encode value in social and non-social decisions? Does the valuation of different types of social stimuli require specific sub-circuits? And how are individual differences between people reflected in these processes? We will address these questions by carrying out parallel experiments in humans and rhesus monkeys, using the complementary techniques of fMRI and electrophysiological recording in both species, and using a variety of basic social and non-social stimuli. Comparisons will be made across species and across single-unit, local field potential, and BOLD-fMRI data, as well as with data from the other Projects and across individual differences.

该项目研究了做出简单社会决策时的基本计算，并将其与简单的非社会决策（例如，基于果汁或金钱的价值，而不是其他人的价值的决策）进行对比。它为所有其他人研究社会奖励的表示方式以及与非社会奖励的比较奠定了基础。非社交决策的一个例子是通过按汽水分配机上的几个按钮之一来选择喝什么，社交决策的一个例子是选择打电话去约会的人。在这里，我们解决这些问题：在社交领域（看到微笑或美丽的面孔），杏仁核和前额皮质中是否有区域编码选择时的刺激值，以及结果时的经验（享乐）值，例如他们在非社交情况下会做什么（口渴时喝果汁）？是否存在专门用于评估社会刺激的神经元，或者相同的细胞是否编码社会和非社会决策中的价值？对不同类型的社会刺激的评估是否需要特定的子电路？而人与人之间的个体差异又如何体现在这些过程中呢？我们将通过在人类和恒河猴中进行平行实验，在这两个物种中使用功能磁共振成像和电生理记录的互补技术，并使用各种基本的社会和非社会刺激来解决这些问题。将跨物种、跨单个单元、局部场电位和 BOLD-fMRI 数据以及来自其他项目的数据和个体差异进行比较。